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Home / Equine Research Bank / Comp Med / Histologic Comparison of the Dura Mater among Species.
Comparative medicine2020; 70(2); 170-175; doi: 10.30802/AALAS-CM-19-000022

Histologic Comparison of the Dura Mater among Species.

Abstract: The biocompatibility, biodegradation, feasibility, and efficacy of medical devices like dural sealants and substitutes are often evaluated in various animal models. However, none of these studies explain the rationale for choosing a particular species, and a systematic interspecies comparison of the dura is not available. We hypothesized that histologic characteristics of the dura would differ among species. We systematically investigated basic characteristics of the dura, including thickness, composition, and fibroblast orientation of the dura mater, in 34 samples representing 10 animal species and compared these features with human dura by using hematoxylin and eosin staining and light microscopy. Dura showed many similarities between species in terms of composition. In all species, dura consisted of at least one fibrovascular layer, which contained collagen, fibroblasts, and blood vessels, and a dural border cell layer beneath the fibrovascular layer. Differences between species included the number of fibrovascular layers, fibroblast orientation, and dural thickness. Human dura was the thickest (564 μm) followed by equine (313 μm), bovine (311 μm), and porcine (304 μm) dura. Given the results of this study and factors such as gross anatomy, feasibility, housing, and ethical considerations, we recommend the use of a porcine model for dural research, especially for in vivo studies.
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Publication Date: 2020-02-03 PubMed ID: 32014084PubMed Central: PMC7137549DOI: 10.30802/AALAS-CM-19-000022Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about a systematic comparison of the dura mater—the outermost layer of the brain and spinal cord—across different animal species, including humans. The study further recommends using pigs as the animal model in dural research due to factors such as anatomy, feasibility, housing, and ethical considerations.

Objective of the Research

  • The overall purpose of this study was to systematically investigate the basic characteristics of the dura mater across ten animal species and humans. This was done to better inform decisions about which animal models to use when testing medical devices such as dural sealants and substitutes.

Methodology

  • The researchers obtained and analyzed 34 samples from ten different animal species and humans.
  • The dura mater from these samples was studied for thickness, composition, and fiber orientation.
  • The analysis was done using techniques such as hematoxylin and eosin staining, and light microscopy.

Findings

  • A significant finding of the study is that in every species, the dura mater consisted of at least one fibrovascular layer containing collagen, fibroblasts, and blood vessels, and a dural border cell layer beneath that.
  • The differences emerged in the number of fibrovascular layers, the orientation of fibroblasts, and the thickness of the dura mater.
  • The human dura was found to be the thickest at 564 μm. The following were the equine (horse) at 313 μm, bovine (cattle) at 311 μm, and porcine (pig) at 304 μm.

Conclusion

  • Based on the findings, the study recommends the use of the pig model for dural research, especially for in vivo studies. This is due to the similarity in thickness and structure to human dura, and also factors such as suitability for housing and relevant ethical considerations.

Cite This Article

APA
Kinaci A, Bergmann W, Bleys RL, van der Zwan A, van Doormaal TP. (2020). Histologic Comparison of the Dura Mater among Species. Comp Med, 70(2), 170-175. https://doi.org/10.30802/AALAS-CM-19-000022

Publication

Comparative medicine
ISSN: 2769-819X
NlmUniqueID: 100900466
Country: United States
Language: English
Volume: 70
Issue: 2
Pages: 170-175

Researcher Affiliations

Kinaci, Ahmet
  • Department of Neurology and Neurosurgery, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Brain Technology Institute, Utrecht, The Netherlands;, Email: akinaci@outlook.com.
Bergmann, Wilhelmina
  • Division ofPathology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Bleys, Ronald Law
  • Department of Anatomy, University Medical Center, Utrecht University, Utrecht, The Netherlands.
van der Zwan, Albert
  • Department of Neurology and Neurosurgery, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Brain Technology Institute, Utrecht, The Netherlands.
van Doormaal, Tristan Pc
  • Department of Neurology and Neurosurgery, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Brain Technology Institute, Utrecht, The Netherlands; Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

MeSH Terms

  • Anatomy, Comparative
  • Animals
  • Animals, Laboratory
  • Dura Mater / anatomy & histology
  • Dura Mater / pathology
  • Female
  • Humans
  • Male

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