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Animals : an open access journal from MDPI2026; 16(1); 143; doi: 10.3390/ani16010143

Histomorphometric Analysis of the Endometrium of Jennies (Equus asinus) and Mares (Equus caballus) in Estrus: Anatomical Differences and Possible Reproductive Implications.

Abstract: Assisted reproductive techniques are often extrapolated from horses to donkeys, despite poorer fertility outcomes in jennies. This issue has been attributed to unknown uterine species-specific differences. This study compared, through histomorphometry, the endometrium of jennies and mares. Endometrial biopsies (N = 12) were taken from reproductively sound jennies (n = 6) and mares (n = 6) in estrus. Histomorphometric analysis evaluated luminal (LE, µm) and glandular epithelium height (GE, µm), glandular lumen diameter (LD, µm), glandular area (GA, µm), the number of glands (#G), and glandular tissue percentage (GT, %), measured in the stratum compactum (SC) and spongiosum (SS). A total of 30 measurements of glandular size parameters and 10 fields of glandular density parameters per sample were recorded. Results were statistically compared between species (jennies vs. mares), parity status (maiden vs. foaling), and stratum (SC vs. SS). Jennies exhibited higher ( < 0.05) values than mares for LE, LD-SC, GA-SC, and GT-SC. These findings suggest that the histomorphometric features observed in reproductively sound jennies reflect anatomical differences that might partly explain previously observed species differences in post-breeding uterine response. In conclusion, histomorphometry revealed significant endometrial differences between species, with jennies displaying taller luminal epithelium, greater glandular size, and higher glandular tissue percentage in the SC than mares.
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Publication Date: 2026-01-04 PubMed ID: 41514829PubMed Central: PMC12784720DOI: 10.3390/ani16010143Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

Overview

  • This study compares the microscopic structure of the uterine lining (endometrium) between jennies (female donkeys) and mares (female horses) during estrus (the fertile phase of the reproductive cycle).
  • The researchers aimed to identify anatomical differences that could explain why jennies typically have lower fertility rates than mares when using assisted reproductive techniques.

Introduction and Background

  • Assisted reproductive technologies (ART) such as artificial insemination and embryo transfer are commonly applied to both horses and donkeys.
  • However, fertility outcomes in donkeys (jennies) are often poorer than in horses (mares), leading to the question of whether differences in uterine anatomy might play a role.
  • The endometrium, or uterine lining, is critical for successful reproduction as it supports embryo attachment and development.
  • Histomorphometry is a method used to quantitatively analyze tissue structure by measuring dimensions and areas of specific components under a microscope.

Study Design and Methods

  • Tissue samples were collected via endometrial biopsies from 6 reproductively sound jennies and 6 reproductively sound mares, all in estrus.
  • Histomorphometric parameters measured included:
    • Luminal epithelium height (LE): Thickness of the lining cells facing the uterine lumen.
    • Glandular epithelium height (GE): Thickness of cells lining the uterine glands.
    • Glandular lumen diameter (LD): Size of the glandular cavity.
    • Glandular area (GA): Total size of the glands.
    • Number of glands (#G): Count of glands per sample field.
    • Glandular tissue percentage (GT): Proportion of tissue occupied by glands.
  • Measurements were made separately in two distinct layers of the endometrium:
    • Stratum compactum (SC): The denser, superficial layer.
    • Stratum spongiosum (SS): The deeper, looser connective tissue layer.
  • Multiple measurements were taken per sample to ensure statistical robustness.
  • Data were statistically compared between species (jennies vs. mares), parity status of mares (maiden vs. foaling), and endometrial layers (SC vs. SS).

Key Findings

  • Jennies showed significantly higher values for several parameters compared to mares:
    • Taller luminal epithelium (LE), suggesting a thicker lining facing the uterine cavity.
    • Larger glandular lumen diameter (LD) in the stratum compactum, indicating bigger gland cavities.
    • Greater glandular area (GA) in the SC, meaning overall larger glands.
    • Higher glandular tissue percentage (GT) in the SC, showing a greater proportion of the tissue is comprised of glands.
  • No mention of significant differences in gland numbers (#G) or glandular epithelium height (GE) was reported in the abstract for jennies versus mares.
  • The distinct endometrial architecture in jennies may reflect species-specific adaptations.

Implications and Conclusion

  • The findings provide anatomical evidence that jennies’ uterine linings differ significantly from mares, particularly in having taller luminal epithelium and larger, more abundant glandular tissue in the stratum compactum.
  • These differences could partly explain the poorer fertility outcomes seen in jennies when using reproductive techniques developed based on horse biology.
  • The greater glandular tissue might affect uterine secretions and interactions with embryos post-breeding, potentially influencing uterine response and fertility.
  • Recognizing these species-specific differences highlights the need for tailored reproductive management and protocols in donkeys rather than direct extrapolation from horses.
  • Overall, histomorphometric analysis is a useful method to uncover subtle but important reproductive anatomical distinctions between closely related species.

Cite This Article

APA
Vallejo-Soto P, Dorado J, Herrera-García R, Álvarez-Delgado C, Gómez-Laguna J, Santiago Á, Manrique M, González Ariza A, León Jurado JM, Hidalgo M, Ortiz I. (2026). Histomorphometric Analysis of the Endometrium of Jennies (Equus asinus) and Mares (Equus caballus) in Estrus: Anatomical Differences and Possible Reproductive Implications. Animals (Basel), 16(1), 143. https://doi.org/10.3390/ani16010143

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 16
Issue: 1
PII: 143

Researcher Affiliations

Vallejo-Soto, Pilar
  • Veterinary Reproduction Group (AGR-275), Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universidad de Córdoba, Ctra. Madrid-Cadiz, Km 396, 14071 Cordoba, Spain.
Dorado, Jesús
  • Veterinary Reproduction Group (AGR-275), Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universidad de Córdoba, Ctra. Madrid-Cadiz, Km 396, 14071 Cordoba, Spain.
Herrera-García, Rafaela
  • Veterinary Reproduction Group (AGR-275), Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universidad de Córdoba, Ctra. Madrid-Cadiz, Km 396, 14071 Cordoba, Spain.
Álvarez-Delgado, Carmen
  • Department of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, International Excellence Agrifood Campus 'CeiA3', Ctra. Madrid-Cadiz, km 396, 14071 Cordoba, Spain.
Gómez-Laguna, Jaime
  • Department of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, International Excellence Agrifood Campus 'CeiA3', Ctra. Madrid-Cadiz, km 396, 14071 Cordoba, Spain.
Santiago, Álvaro de
  • Military Centre of Equine Breeding of Ecija, C. Nueva, 2, 41400 Ecija, Spain.
Manrique, María
  • Military Centre of Equine Breeding of Ecija, C. Nueva, 2, 41400 Ecija, Spain.
González Ariza, Antonio
  • Agropecuary Provincial Centre, Diputación de Córdoba, Ctra. Madrid-Cadiz, Km 396, 14014 Cordoba, Spain.
León Jurado, José Manuel
  • Agropecuary Provincial Centre, Diputación de Córdoba, Ctra. Madrid-Cadiz, Km 396, 14014 Cordoba, Spain.
Hidalgo, Manuel
  • Veterinary Reproduction Group (AGR-275), Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universidad de Córdoba, Ctra. Madrid-Cadiz, Km 396, 14071 Cordoba, Spain.
Ortiz, Isabel
  • Veterinary Reproduction Group (AGR-275), Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universidad de Córdoba, Ctra. Madrid-Cadiz, Km 396, 14071 Cordoba, Spain.

Grant Funding

  • UCO-13811332-R / FEDER Andalucía 2014-2020
  • PID2020-116090RB-100 / Ministerio de Ciencia e Innovación, Spain
  • FPU23/03472 / the Spanish FPU fellowship (FPU23/03472) from MUNI (Ministerio de Universidades)

Conflict of Interest Statement

The authors declare no conflicts of interest.

References

This article includes 57 references
  1. Food and Agriculture Organization (FAO) Domestic Animal Diversity Information System (DAD-IS) [(accessed on 13 March 2025)]. Available online: https://www.fao.org/dad-is/en/
  2. Camillo F, Rota A, Biagini L, Tesi M, Fanelli D, Panzani D. The Current Situation and Trend of Donkey Industry in Europe. J. Equine Vet. Sci. 2018;65:44–49.
    doi: 10.1016/j.jevs.2017.11.008google scholar: lookup
  3. Hedrick P.W., Garcia-Dorado A. Understanding Inbreeding Depression, Purging, and Genetic Rescue. Trends Ecol. Evol. 2016;31:940–952.
    doi: 10.1016/j.tree.2016.09.005pubmed: 27743611google scholar: lookup
  4. Kenney R.M.. Cyclic and pathologic changes of the mare endometrium as detected by biopsy, with a note on early embryonic death. J. Am. Vet. Med. Assoc. 1978;172:242–262.
    doi: 10.2460/javma.1978.172.03.241pubmed: 621166google scholar: lookup
  5. Kenney R.M., Doig P.A.. Equine endometrial biopsy. Curr. Ther. Theriogenol. 1986;2:723–729.
  6. Hildebrandt T.B., Hermes R., Goeritz F., Appeltant R., Colleoni S., de Mori B., Diecke S., Drukker M., Galli C., Hayashi K.. The ART of bringing extinction to a freeze—History and future of species conservation, exemplified by rhinos. Theriogenology 2021;169:76–88.
    doi: 10.1016/j.theriogenology.2021.04.006pubmed: 33940218google scholar: lookup
  7. De Oliveira J.V., Oliveira P.V.L.F., e Oña C.M.M., Guasti P.N., Monteiro G.A., da Silva Y.F.R.S., de Mello Papa P., Alvarenga M.A., Dell’Aqua Junior J.A., Ozanam Papa F.. Strategies to improve the fertility of fresh and frozen donkey semen. Theriogenology 2016;85:1267–1273.
    doi: 10.1016/j.theriogenology.2015.12.010pubmed: 26806444google scholar: lookup
  8. Panzani D., Fanelli D., Camillo F., Rota A.. Embryo technologies in donkeys (Equus asinus). Theriogenology 2020;156:130–137.
    doi: 10.1016/j.theriogenology.2020.06.041pubmed: 32707428google scholar: lookup
  9. Fanelli D., Moroni R., Bocci C., Camillo F., Rota A., Panzani D.. Interspecific and Intraspecific Artificial Insemination in Domestic Equids. Animals 2023;13:582.
    doi: 10.3390/ani13040582pmc: PMC9951644pubmed: 36830369google scholar: lookup
  10. Hidalgo M.. Sperm vitrification in horses and donkeys. J. Equine Vet. Sci. 2025;145:105340.
    doi: 10.1016/j.jevs.2024.105340pubmed: 39793937google scholar: lookup
  11. Vidament M., Vincent P., Martin F.X., Magistrini M., Blesbois E.. Differences in ability of jennies and mares to conceive with cooled and frozen semen containing glycerol or not. Anim. Reprod. Sci. 2009;112:22–35.
    doi: 10.1016/j.anireprosci.2008.03.016pubmed: 18502059google scholar: lookup
  12. Rota A., Panzani D., Sabatini C., Camillo F.. Donkey jack (Equus asinus) semen cryopreservation: Studies of seminal parameters, post breeding inflammatory response, and fertility in donkey jennies. Theriogenology 2012;78:1846–1854.
    doi: 10.1016/j.theriogenology.2012.07.015pubmed: 22979965google scholar: lookup
  13. Vilés K., Rabanal R., Rodríguez-Prado M., Miró J.. Effect of ketoprofen treatment on the uterine inflammatory response after AI of jennies with frozen semen. Theriogenology 2013;79:1019–1026.
    doi: 10.1016/j.theriogenology.2013.01.006pubmed: 23453786google scholar: lookup
  14. Miró J., Papas M.. Post–Artificial Insemination Endometrial Inflammation and Its Control in Donkeys. J. Equine Vet. Sci. 2018;65:38–43.
    doi: 10.1016/j.jevs.2017.11.007google scholar: lookup
  15. Canisso I.F., Panzani D., Miró J., Ellerbrock R.E.. Key Aspects of Donkey and Mule Reproduction. Vet. Clin. N. Am.—Equine Pract. 2019;35:607–642.
    doi: 10.1016/j.cveq.2019.08.014pubmed: 31672204google scholar: lookup
  16. Taberner E., Medraño A., Peña A., Rigau T., Miró J. Oestrus cycle characteristics and prediction of ovulation in Catalonian jennies. Theriogenology. 2008;70:1489–1497. doi: 10.1016/j.theriogenology.2008.06.096.
    doi: 10.1016/j.theriogenology.2008.06.096pubmed: 18678401google scholar: lookup
  17. Galisteo J., Perez-Marin C.C. Factors affecting gestation length and estrus cycle characteristics in Spanish donkey breeds reared in southern Spain. Theriogenology. 2010;74:443–450. doi: 10.1016/j.theriogenology.2010.02.027.
    doi: 10.1016/j.theriogenology.2010.02.027pubmed: 20451997google scholar: lookup
  18. McLean A.K., Navas González F.J., Canisso I.F. Donkey and Mule Behavior. Vet. Clin. N. Am.—Equine Pract. 2019;35:575–588. doi: 10.1016/j.cveq.2019.08.010.
    doi: 10.1016/j.cveq.2019.08.010pubmed: 31672203google scholar: lookup
  19. Renner-Martin T.F.P., Forstenpointer G., Weissengruber G.E., Eberhardt L. Gross anatomy of the female genital organs of the domestic donkey (Equus asinus Lineé, 1758) J. Vet. Med. Ser. C Anat. Histol. Embryol. 2009;38:133–138. doi: 10.1111/j.1439-0264.2008.00911.x.
    doi: 10.1111/j.1439-0264.2008.00911.xpubmed: 19007353google scholar: lookup
  20. Quartuccio M., Cristarella S., Medica P., Fazio E., Mazzullo G., Rifici C., Liotta L., Satué K. Endometrial cytology during the different phases of the estrous cycle in Jennies: New evidences. Animals. 2020;10:1062. doi: 10.3390/ani10061062.
    doi: 10.3390/ani10061062pmc: PMC7341222pubmed: 32575538google scholar: lookup
  21. Abdelnaeim M. Morphological Characteristics of the Donkey (Equus asinus) Uterus during Estrus: Light, Scanning and Transmission Electron Microscopic Study. J. Agric. Vet. Sci. 2008;2:45–57.
  22. Miró J., Gutiérrez-Reinoso M., da Silva J.A., Fernandes C., Rebordao M.R., Alexandre-Pires G., Catalán J., Ferreira-Dias G. Collagen and Eosinophils in Jenny’s Endometrium: Do They Differ with Endometrial Classification? Front. Vet. Sci. 2020;10:7. doi: 10.3389/fvets.2020.00631.
    doi: 10.3389/fvets.2020.00631pmc: PMC7511575pubmed: 33134338google scholar: lookup
  23. Allen W.R., Wilsher S. A Review of Implantation and Early Placentation in the Mare. Placenta. 2009;30:1005–1015. doi: 10.1016/j.placenta.2009.09.007. Corrigendum in Placentan2010, 31, 560. https://doi.org/10.1016/j.placenta.2010.03.011 .
    doi: 10.1016/j.placenta.2009.09.007pubmed: 19850339google scholar: lookup
  24. Bracher V., Mathias S., Allen W.R. Influence of chronic degenerative endometritis (endometriosis) on placental development in the mare. Equine Vet. J. 1996;28:180–188. doi: 10.1111/j.2042-3306.1996.tb03771.x.
    doi: 10.1111/j.2042-3306.1996.tb03771.xpubmed: 28976715google scholar: lookup
  25. Alfradique V.A.P., Netto D.L.S., Alves S.V.P., Machado A.F., Novaes C.M., Penitente-Filho J.M., Machado-Neves M., Lopes M.S., Guimaraes S.E.F. The impact of FSH stimulation and age on the ovarian and uterine traits and histomorphometry of prepubertal gilts. Domest. Anim. Endocrinol. 2023;83:106786. doi: 10.1016/j.domaniend.2023.106786.
    doi: 10.1016/j.domaniend.2023.106786pubmed: 36848729google scholar: lookup
  26. Wang C.K., Robinson R.S., Flint A.P.F., Mann G.E. Quantitative analysis of changes in endometrial gland morphology during the bovine oestrous cycle and their association with progesterone levels. Reproduction. 2007;134:365–371. doi: 10.1530/REP-06-0133.
    doi: 10.1530/REP-06-0133pubmed: 17660245google scholar: lookup
  27. Lefranc A.C., Allen W.R. Influence of breed and oestrous cycle on endometrial gland surface density in the mare. Equine Vet. J. 2007;39:506–510. doi: 10.2746/042516407X235812.
    doi: 10.2746/042516407X235812pubmed: 18065307google scholar: lookup
  28. Abdoon A.S.S., Soliman S.S., Nagy A.M. Uterotubal junction of the bovine (Bos taurus) versus the dromedary camel (Camelus dromedarius): Histology and histomorphometry. Reprod. Domest. Anim. 2024;59:e14665. doi: 10.1111/rda.14665.
    doi: 10.1111/rda.14665pubmed: 38973694google scholar: lookup
  29. Dubrovskaya A.B., Lebedeva L.F., Schukis K.A. Comparative histomorphological characteristics of the endometrium of young and aged mares in estrus and diestrus. IOP Conf. Ser. Earth Environ. Sci. 2019;341:012067. doi: 10.1088/1755-1315/341/1/012067.
    doi: 10.1088/1755-1315/341/1/012067google scholar: lookup
  30. Mansour G.D., Ferreira A.M.R., Fernandes F.T., Henry M. Histomorphometry of epithelial structures of the mare’s endometrium. Rev. Bras. Ciência Veterinária. 2004;11:44–48. doi: 10.4322/rbcv.2014.341.
    doi: 10.4322/rbcv.2014.341google scholar: lookup
  31. Herrera M., Herrera J.M., Cantatore S., Aguilar J., Felipe A., Fumuso E. Comparative histomorphological study of endometrium in mares. J. Vet. Med. Ser. C Anat. Histol. Embryol. 2018;47:153–158. doi: 10.1111/ahe.12335.
    doi: 10.1111/ahe.12335pubmed: 29314167google scholar: lookup
  32. Rasch K., Schoon H.A., Sieme H., Klug E. Histomorphological endometrial status and influence of oxytocin on the uterine drainage and pregnancy rate in mares. Equine Vet. J. 1996;28:455–460. doi: 10.1111/j.2042-3306.1996.tb01617.x.
    doi: 10.1111/j.2042-3306.1996.tb01617.xpubmed: 9049494google scholar: lookup
  33. Herrera M.F., Otermin M., Herrera J.M., Simoy M.V., Bianchi C.P., Aguilar J.J., Fumuso E.A. Effect of Mycobacterium cell wall fraction on endometrial histomorphometry of mares resistant and susceptible to persistent breeding-induced endometritis. Theriogenology. 2020;156:2–10. doi: 10.1016/j.theriogenology.2020.06.034.
    doi: 10.1016/j.theriogenology.2020.06.034pubmed: 32652325google scholar: lookup
  34. Love C.C. Evaluation of reproductive efficiency. In: Samper J.C., editor. Equine Breeding Management and Artificial Insemination. 2nd ed. Saunders; Philadelphia, PA, USA: 2009. pp. 289–294.
    doi: 10.1016/B978-1-4160-5234-0.00026-Xgoogle scholar: lookup
  35. Card C. Post-breeding inflammation and endometrial cytology in mares. Theriogenology. 2005;64:580–588. doi: 10.1016/j.theriogenology.2005.05.041.
    doi: 10.1016/j.theriogenology.2005.05.041pubmed: 15978660google scholar: lookup
  36. Samper J.C. A review of a practitioner’s perspective on endometrial edema. Pferdeheilkunde. 2010;26:14–18. doi: 10.21836/PEM20100103.
    doi: 10.21836/PEM20100103google scholar: lookup
  37. Hinrichs K., Cummings M.R., Sertich P.L., Kenney R.M. Clinical significance of aerobic bacterial flora of the uterus, vagina, vestibule, and clitoral fossa of clinically normal mares. J. Am. Vet. Med. Assoc. 1988;193:72–75. doi: 10.2460/javma.1988.193.01.72.
    doi: 10.2460/javma.1988.193.01.72pubmed: 3417532google scholar: lookup
  38. Dascanio J.J. Uterine Lavage. In: Dascanio J.J., McCue P., editors. Equine Reproductive Procedures. 2nd ed. John Wiley & Sons; Hoboken, NJ, USA: 2021. pp. 127–130.
    doi: 10.1002/9781119556015.ch34google scholar: lookup
  39. Aguilar J., Hanks M., Shaw D.J., Else R., Watson E. Importance of using guarded techniques for the preparation of endometrial cytology smears in mares. Theriogenology. 2006;66:423–430. doi: 10.1016/j.theriogenology.2005.12.007.
    doi: 10.1016/j.theriogenology.2005.12.007pubmed: 16427691google scholar: lookup
  40. Rasmussen C.D., Petersen M.R., Bojesen A.M., Pedersen H.G., Lehn-Jensen H., Christoffersen M. Equine Infectious Endometritis—Clinical and Subclinical Cases. J. Equine Vet. Sci. 2015;35:95–104. doi: 10.1016/j.jevs.2014.12.002.
    doi: 10.1016/j.jevs.2014.12.002google scholar: lookup
  41. Álvarez-Delgado C., Ruedas-Torres I., Sánchez-Carvajal J.M., Priego-Capote F., Castillo-Peinado L., Galán-Relaño Á., Moreno P.J., Díaz-Bueno E., Lozano-Buenestado B., Rodríguez-Gómez I.M., et al. Impact of supplementation with dihydroxylated vitamin D3 on performance parameters and gut health in weaned Iberian piglets under indoor/outdoor conditions. Porc. Health Manag. 2023;9:15. doi: 10.1186/s40813-023-00307-z.
    doi: 10.1186/s40813-023-00307-zpmc: PMC10266876pubmed: 37316951google scholar: lookup
  42. Leishman D., Miller R.B., Doig P.A. A Quantitative Study of the Histological Morphology of the Endometrium of Normal and Barren Mares. Can. J. Comp. Med. 1982;46:17–20.
    pmc: PMC1320187pubmed: 7200386
  43. Van Camp S.D. Endometrial biopsy of the mare. A review and update. Vet. Clin. N. Am. Equine Pr. 1988;4:229–245. doi: 10.1016/S0749-0739(17)30639-9.
    doi: 10.1016/S0749-0739(17)30639-9pubmed: 3044538google scholar: lookup
  44. Causey R.C. Mucus and the mare: How little we know. Theriogenology. 2007;68:386–394. doi: 10.1016/j.theriogenology.2007.04.011.
    doi: 10.1016/j.theriogenology.2007.04.011pubmed: 17512579google scholar: lookup
  45. Troedsson M.H.T., Liu I.K.M., Thurmond M. Function of uterine and blood-derived polymorphonuclear neutrophils in mares susceptible and resistant to chronic uterine infection: Phagocytosis and chemotaxis. Biol. Reprod. 1993;49:507–514. doi: 10.1095/biolreprod49.3.507.
    doi: 10.1095/biolreprod49.3.507pubmed: 8399843google scholar: lookup
  46. Petersen M.R., Skive B., Christoffersen M., Lu K., Nielsen J.M., Troedsson M.H.T., Bojesen A.M. Activation of persistent Streptococcus equi subspecies zooepidemicus in mares with subclinical endometritis. Vet. Microbiol. 2015;179:119–125. doi: 10.1016/j.vetmic.2015.06.006.
    doi: 10.1016/j.vetmic.2015.06.006pubmed: 26123371google scholar: lookup
  47. Ferris R.A., Mccue P.M., Borlee G.I., Glapa K.E., Martin K.H., Mangalea M.R., Hennet M.L., Wolfe M.L., Broeckling C.D., Borlee B.R. Model of Chronic Equine Endometritis Involving a Pseudomonas aeruginosa Biofilm. Infect. Inmunity. 2017;85:e00332-17. doi: 10.1128/IAI.00332-17.
    doi: 10.1128/IAI.00332-17pmc: PMC5695105pubmed: 28970274google scholar: lookup
  48. Skive B., Rohde M., Molinari G., Braunstein T.H., Bojesen A.M. Streptococcus equi subsp. zooepidemicus invades and survives in epithelial cells. Front. Cell Infect. Microbiol. 2017;7:465. doi: 10.3389/fcimb.2017.00465.
    doi: 10.3389/fcimb.2017.00465pmc: PMC5681531pubmed: 29164073google scholar: lookup
  49. Köhne M., Hüsch R., Tönissen A., Schmidt M., Müsken M., Böttcher D., Hirnet J., Plötz M., Kittler S., Sieme H. Isolation and characterization of bacteriophages specific to Streptococcus equi subspecies zooepidemicus and evaluation of efficacy ex vivo. Front. Microbiol. 2024;15:1448958. doi: 10.3389/fmicb.2024.1448958.
    doi: 10.3389/fmicb.2024.1448958pmc: PMC11550937pubmed: 39529671google scholar: lookup
  50. Veiga G.A.L., Miziara R.H., Angrimani D.S.R., Papa P.C., Cogliati B., Vannucchi C.I. Cystic endometrial hyperplasia-pyometra syndrome in bitches: Identification of hemodynamic, inflammatory, and cell proliferation changes. Biol. Reprod. 2017;96:58–69. doi: 10.1095/biolreprod.116.140780.
    doi: 10.1095/biolreprod.116.140780pubmed: 28395328google scholar: lookup
  51. Radar-Chafirovitch A., Catarino J., Lourenço L., Payan-Carreira R., Ferreira-Dias G., Miró J., Quaresma M., Pires M.A. Evaluation of Inflammatory Infiltrated in the Endometrium of the Jenny (Equus asinus) J. Comp. Pathol. 2022;191:46. doi: 10.1016/j.jcpa.2021.11.104.
    doi: 10.1016/j.jcpa.2021.11.104google scholar: lookup
  52. Wu R., Yu F., Holyoak G.R., Gao Y., Zhu Y., Li J. Use of the endometrial histopathology to improve diagnosis of donkeys with endometritis. Equine Vet. Educ. 2023;36:43–50. doi: 10.1111/eve.13815.
    doi: 10.1111/eve.13815google scholar: lookup
  53. Lopes Costa L.M., Sancler-Silva Y.F.R., Albino M.V., Fontes C.S., Texeira C.S., Freitas M.S., Kladt L.V., Schultz E.B. Does the uterine inflammatory response differ between mares and donkey jennies inseminated with frozen donkey semen? J. Equine Vet. Sci. 2023;125:104703. doi: 10.1016/j.jevs.2023.104703.
    doi: 10.1016/j.jevs.2023.104703google scholar: lookup
  54. Diaz-Jimenez M., Rota A., Dorado J., Consuegra C., Pereira B., Camillo F., Panzani D., Fanelli D., Tesi M., Monaco D., et al. First pregnancies in jennies with vitrified donkey semen using a new warming method. Animal. 2021;15:100097. doi: 10.1016/j.animal.2020.100097.
    doi: 10.1016/j.animal.2020.100097pubmed: 33516021google scholar: lookup
  55. Gerstenberg C., Allen W.R., Stewart F. Cell proliferation patterns in the equine endometrium throughout the non-pregnant reproductive cycle. J. Reprod. Fertil. 1999;116:167–175. doi: 10.1530/jrf.0.1160167.
    doi: 10.1530/jrf.0.1160167pubmed: 10505067google scholar: lookup
  56. Nielsen J.M. Endometritis in the mare: A diagnostic study comparing cultures from swab and biopsy. Theriogenology. 2005;64:510–518. doi: 10.1016/j.theriogenology.2005.05.034.
    doi: 10.1016/j.theriogenology.2005.05.034pubmed: 15978661google scholar: lookup
  57. Rudolph N., Schoon H.A., Schöniger S. Immunohistochemical characterisation of immune cells in fixed equine endometrial tissue: A diagnostic relevant method. Pferdeheilkunde. 2017;33:524–537. doi: 10.21836/PEM20170601.
    doi: 10.21836/PEM20170601google scholar: lookup

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