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IGF -I plasma concentrations in non-treated horses and horses administered with methionyl equine somatotropin.
Abstract: Insulin-like growth factor-I (IGF -I) is likely to be an indicator of somatotropin (ST) administration in the horse. To investigate the different ways ST administration may be detected, the following aspects of IGF -I concentrations in plasma were studied: (i) the daily variation; (ii) variation following a treadmill test; (iii) concentrations at rest and after exercise; and (iv) concentrations in plasma from two young horses and two adults treated with methionyl equine somatotropin (e ST). In the population of horses at rest, IGF -I mean concentration (SEM) was 261 (104) ng ml(-1). In post race samples, IGF -I mean concentration was 187 (100) ng ml(-1). All of these data indicate that exercise does not modify IGF -I concentration in plasma. The magnitude of the increase in IGF -I following administration of e ST differed according to the age of the horses. The critical value of 700 ng ml(-1)was exceeded for 1 day in adult horses and for at least 11 days in young horses. These results show that IGF -I has potential as an indirect marker of ST administration in horses.
Copyright 2001 Harcourt Publishers Ltd.
Publication Date: 2002-01-19 PubMed ID: 11798290DOI: 10.1053/rvsc.2001.0505Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study investigates the potential use of Insulin-like Growth Factor-I (IGF-I) as an indicator of somatotropin (ST) administration in horses. The results showed that IGF-I concentrations did not change with exercise, but varied greatly following ST administration, especially in young horses.
Introduction
The research discusses the possible application of Insulin-like Growth Factor-I (IGF-I) as a marker to detect administration of somatotropin (ST) in horses. ST is a peptide hormone that stimulates growth and cell reproduction in animals and humans. In this study, the researchers examined the variation in IGF-I concentrations in relation to daily variation, treadmill test impact, and its amount at rest and post-exercise.
IGF-I Concentrations at Rest and Post-Exercise
- The IGF-I mean concentration in horses at rest was found to be 261 (104) ng ml(-1).
- Following exercise, the concentration was slightly lower, with a mean reading of 187 (100) ng ml(-1).
- The researchers observed that there was no significant variation in IGF-I levels due to physical exertion. This suggests that the IGF-I concentration in a horse’s plasma remains relatively stable irrespective of exercise.
IGF-I Concentrations Following ST Administration
- The study further investigated changes in IGF-I concentrations following the administration of methionyl equine somatotropin, a synthetic version of ST.
- It was observed that the increase in IGF-I post-administration differed based on the age of the animals. The critical value of 700 ng ml(-1) was surpassed for 1 day in adult horses and for at least 11 days in young horses.
- This notable difference in IGF-I levels, especially in younger horses, indicates the potential of IGF-I to act as an indirect marker for ST administration.
Conclusion
Based on these findings, the paper suggests that IGF-I can be used as a potential indirect marker of ST administration. By observing the IGF-I levels in horses’ plasma, especially after the administration of synthetic ST, doping in equine sports can potentially be detected and regulated.
Cite This Article
APA
Popot MA, Bobin S, Bonnaire Y, Delahaut PH, Closset J.
(2002).
IGF -I plasma concentrations in non-treated horses and horses administered with methionyl equine somatotropin.
Res Vet Sci, 71(3), 167-173.
https://doi.org/10.1053/rvsc.2001.0505 Publication
Researcher Affiliations
- LAB/FNCF, 169 Avenue de la Division Leclerc, Châtenay-Malabry 92290, France. mariepopot@wanadoo.fr
MeSH Terms
- Age Factors
- Animals
- Biomarkers / analysis
- Circadian Rhythm / physiology
- Doping in Sports
- Exercise Test / veterinary
- Female
- Growth Hormone / administration & dosage
- Growth Hormone / blood
- Horses / blood
- Insulin-Like Growth Factor I / analysis
- Insulin-Like Growth Factor I / metabolism
- Jugular Veins
- Male
- Physical Conditioning, Animal / physiology
- Reference Values
- Rest / physiology
Citations
This article has been cited 3 times.- Ferlazzo A, Cravana C, Fazio E, Medica P. The different hormonal system during exercise stress coping in horses. Vet World 2020 May;13(5):847-859.
- Baskerville CL, Bamford NJ, Harris PA, Bailey SR. Comparison and validation of ELISA assays for plasma insulin-like growth factor-1 in the horse. Open Vet J 2017;7(1):75-80.
- Salazar-Ortiz J, Camous S, Briant C, Lardic L, Chesneau D, Guillaume D. Effects of nutritional cues on the duration of the winter anovulatory phase and on associated hormone levels in adult female Welsh pony horses (Equus caballus). Reprod Biol Endocrinol 2011 Sep 29;9:130.
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