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Home / Equine Research Bank / Biomed Res Int / Immunomodulatory Role of Adipose-Derived Stem Cells on Equin...
BioMed research international2015; 2015; 141485; doi: 10.1155/2015/141485

Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis.

Abstract: Endometriosis is a degenerative process due to a chronic inflammatory damage leading to extracellular matrix components deposition and glandular fibrosis. It is known that mesenchymal stem cells secrete a wide range of bioactive molecules, some of them modulating the immune inflammatory response, and others providing regeneration and remodeling of injured tissue. We have performed in vitro experiments in order to analyze the capability of allogenic equine adipose-derived stem cells (ADSCs) to infiltrate mares' endometrial tissues and to stimulate the expression of cytokines and metallopeptidases. Differences in the biologic response to the exposure to ADSCs between pathological and healthy endometrial tissue have been identified. These results could challenge researchers to progress forward with future studies for the development of a biological therapy with a possible application in translational medicine.
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Publication Date: 2015-06-09 PubMed ID: 26180781PubMed Central: PMC4477049DOI: 10.1155/2015/141485Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates the potential of equine adipose-derived stem cells (ADSCs) in modulating the immune inflammatory response and damage in endometriosis in horses. It provides insight into how ADSCs can affect the expression of cytokines and metalloproteinases, indicating potential for a biological treatment approach.

Research context and objectives

  • The study centers on endometriosis, a degenerative condition associated with chronic inflammatory damage. It results in the deposition of extracellular matrix components and glandular fibrosis.
  • Mesenchymal stem cells, which have been known to secrete a variety of bioactive molecules, were the focus of this study. Some of these molecules can modulate the immune inflammatory response, while others promote the regeneration and remodeling of damaged tissue.
  • The primary objective of the research was to examine the capacity of equine adipose-derived stem cells (ADSCs) to infiltrate the endometrial tissues of mares and stimulate the expression of cytokines and metallopeptidases.

Methods and findings

  • The research team performed in vitro experiments, working directly with cells and tissues outside their normal biological context.
  • They found that the exposure to ADSCs triggered different biological responses between healthy and pathological (diseased) endometrial tissue. This suggests that ADSCs have particular ways of interacting with disease processes in the endometrium.
  • Although the research was conducted on horses, its findings have potential implications for understanding and treating endometriosis in other mammals, including humans.

Conclusion and future implications

  • These findings provide a new perspective on the role of ADSCs in treating endometriosis. It suggests that these cells can influence the immune inflammatory response and tissue recovery in the endometrium.
  • Future studies are likely to expand on these findings and pursue the development of a biological treatment for endometriosis based on the application of ADSCs.
  • This has the potential to contribute significantly to translational medicine, the field that aims to “translate” findings in fundamental research into medical practice and meaningful health outcomes.

Cite This Article

APA
Falomo ME, Ferroni L, Tocco I, Gardin C, Zavan B. (2015). Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis. Biomed Res Int, 2015, 141485. https://doi.org/10.1155/2015/141485

Publication

BioMed research international
ISSN: 2314-6141
NlmUniqueID: 101600173
Country: United States
Language: English
Volume: 2015
Pages: 141485
PII: 141485

Researcher Affiliations

Falomo, Maria Elena
  • Department of Veterinary Clinical Sciences, Viale dell'Università 16, 35100 Padua, Italy.
Ferroni, Letizia
  • Department of Biomedical Sciences, University of Padua, Via G. Colombo 3, 35100 Padua, Italy.
Tocco, Ilaria
  • Department of Neurosciences, University of Padua, Via Giustiniani 2, 35100 Padua, Italy.
Gardin, Chiara
  • Department of Biomedical Sciences, University of Padua, Via G. Colombo 3, 35100 Padua, Italy.
Zavan, Barbara
  • Department of Biomedical Sciences, University of Padua, Via G. Colombo 3, 35100 Padua, Italy.

MeSH Terms

  • Adipose Tissue / immunology
  • Allografts
  • Animals
  • Cytokines / immunology
  • Endometriosis / immunology
  • Endometriosis / therapy
  • Endometriosis / veterinary
  • Female
  • Gelatinases / immunology
  • Horse Diseases / immunology
  • Horse Diseases / therapy
  • Horses
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells / immunology

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Citations

This article has been cited 13 times.
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