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Journal of veterinary internal medicine2019; 33(3); 1473-1482; doi: 10.1111/jvim.15497

Incidence and risk factors for recurrence of endocrinopathic laminitis in horses.

Abstract: Endocrinopathic laminitis is common in horses and ponies, but the recurrence rate of the disease is poorly defined. Objective: To determine the incidence of, and risk factors for, the recurrence of endocrinopathic laminitis. Methods: Privately owned horses and ponies with acute laminitis (n = 317, of which 276 cases with endocrinopathic laminitis were followed up to study completion). Methods: This prospective cohort study collected data on veterinary-diagnosed cases of acute laminitis for 2 years. Each case was classified on acceptance to the study as endocrinopathic or non-endocrinopathic using data collected in a questionnaire completed by the animal's veterinarian. Follow-up data were collected at regular intervals to determine whether the laminitis recurred in the 2-year period after diagnosis. Results: The recurrence rate for endocrinopathic laminitis was 34.1%. The risk of recurrence during the 2-year study period increased with basal, fasted serum insulin concentration (P ≤ .05), with the probability of recurrence increasing markedly as the insulin concentration increased beyond the normal range (0-20 μIU/mL) to over the threshold for normal (up to approximately 45 μIU/mL). Being previously diagnosed with laminitis (before the study; P = .05) was also a risk factor for recurrent laminitis. Cases with a higher Obel grade of laminitis were likely (P = .05) to recur sooner. Conclusions: Knowing that hyperinsulinemia and being previously diagnosed with laminitis are significant risk factors for recurrence will enable clinicians to proactively address these factors, thereby potentially reducing the risk of recurrence of laminitis.
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2019-04-10 PubMed ID: 30972832PubMed Central: PMC6524073DOI: 10.1111/jvim.15497Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study provides an analysis of the recurrence of endocrinopathic laminitis in privately owned horses and ponies. It identifies hyperinsulinemia and prior instances of laminitis as significant risk factors for the reoccurrence of the disease.

Research Objectives and Methodology

  • The primary aim of the study was to pinpoint the incidence as well as risk factors linked to the recurrence of endocrinopathic laminitis in horses and ponies.
  • 317 horses and ponies experiencing acute laminitis were investigated in the study. Out of these, 276 instances of endocrinopathic laminitis were pursued till the termination of the study.
  • It was a prospective cohort study, in which data was recorded for 2 years on veterinary-diagnosed incidents of acute laminitis.
  • Each case was categorized as endocrinopathic or non-endocrinopathic laminitis based on the information collected via a questionnaire completed by each animal’s vet.
  • The study regularly collected follow-up data in order to find out whether the laminitis recurred within the 2-year duration post-diagnosis.

Results and Findings

  • The recurrence rate for endocrinopathic laminitis was found to be 34.1% during the study.
  • The risk of recurrence in the 2-year period of the study increased with the basal, fasted serum insulin concentration, with the probability of recurrence amplifying notably as the insulin concentration rose past the normal range (0-20 μIU/mL) to beyond the normal threshold (approximately 45 μIU/mL).
  • A previous diagnosis of laminitis (prior to the initiation of the study) was also found to increase the risk of recurrent laminitis.
  • Cases having a higher Obel grade of laminitis were more likely to experience a recurrence sooner.

Conclusions and Implications

  • The study concluded that hyperinsulinemia and a previous diagnosis of laminitis are significant risk factors for the recurrence of endocrinopathic laminitis.
  • This knowledge can be leveraged by clinicians to proactively address these factors, in order to potentially reduce the risk of laminitis recurrence.

Cite This Article

APA
de Laat MA, Reiche DB, Sillence MN, McGree JM. (2019). Incidence and risk factors for recurrence of endocrinopathic laminitis in horses. J Vet Intern Med, 33(3), 1473-1482. https://doi.org/10.1111/jvim.15497

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 33
Issue: 3
Pages: 1473-1482

Researcher Affiliations

de Laat, Melody A
  • Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.
Reiche, Dania B
  • Animal Health, Boehringer Ingelheim Vetmedica GmbH, Ingelheim am Rhein, Germany.
Sillence, Martin N
  • Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.
McGree, James M
  • Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.

MeSH Terms

  • Animals
  • Cohort Studies
  • Endocrine System Diseases / complications
  • Endocrine System Diseases / veterinary
  • Female
  • Foot Diseases / epidemiology
  • Foot Diseases / etiology
  • Foot Diseases / veterinary
  • Hoof and Claw
  • Horse Diseases
  • Horses
  • Hyperinsulinism / veterinary
  • Incidence
  • Male
  • Prospective Studies
  • Recurrence
  • Risk Factors

Grant Funding

  • Boehringer Ingelheim

Conflict of Interest Statement

Authors declare no conflict of interest.

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Citations

This article has been cited 14 times.
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