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Veterinary anaesthesia and analgesia2026; 53(3); 101216; doi: 10.1016/j.vaa.2026.101216

Investigating the effect of surface cryotherapy on equine patient compliance to infraorbital nerve block placement.

Abstract: To investigate the effect of applying ice to the skin overlying the infraorbital canal on the compliance of healthy adult horses to infraorbital nerve block placement during standing sedation. Methods: Blinded, randomized crossover trial. Methods: Thirty healthy adult horses [16 ± 3.9 years old (mean ± standard deviation), weighing 594 ± 63 kilograms (kg)]. Methods: Each horse acted as its own control with a minimum of 7 days between treatments. Horses were sedated using detomidine hydrochloride, and sedation level was evaluated using a published simple descriptive scale. Horses were randomly assigned to 5 minutes of icing (ICE) or no icing (N-ICE) before block placement. An infraorbital nerve block was performed using 5 mL of mepivacaine 2%. Block efficacy was tested using a 25-gauge needle prick. Nerve blocks were filmed and reviewed by two investigators blinded to treatment, and horse compliance was assessed using a visual analogue scale (VAS) from 0 to 10. Investigator scores were added together for a total score out of 20. VAS scores were evaluated using a paired t-test. Any adverse effects were documented. Results: There was no significant difference in compliance scores between groups (P = 0.179). VAS score for the ICE and N-ICE groups was 13.74 ± 6.2 and 11.81 ± 6.9, respectively. In the ICE group, 24/30 blocks were considered successful, versus 18/30 in the N-ICE group. No adverse effects were noted associated with icing. Conclusions: Icing of the skin did not significantly improve compliance to infraorbital nerve block placement in sedated horses.
Publication Date: 2026-02-26 PubMed ID: 41996948DOI: 10.1016/j.vaa.2026.101216Google Scholar: Lookup
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  • Journal Article

Summary

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Overview

Objective and Background

  • The primary goal was to determine if surface cryotherapy (applying ice) to the skin over the infraorbital canal would enhance compliance in horses undergoing infraorbital nerve block placement.
  • The infraorbital nerve block is commonly used in equine veterinary medicine for analgesia during procedures involving the face.
  • Compliance during block placement can be challenging because of discomfort or sensitivity; improving compliance could help in smoother and safer procedures.
  • Cryotherapy (icing) is known to reduce pain and discomfort in other contexts by numbing the skin and underlying tissues.

Study Design

  • Type: Blinded, randomized crossover trial.
  • Subjects: 30 healthy adult horses with an average age of 16 years and mean weight around 594 kg.
  • Each horse served as its own control by undergoing both treatments (icing and no icing), separated by at least 7 days to avoid carryover effects.
  • Horses were sedated with detomidine hydrochloride to standardize sedation level prior to the nerve block.
  • Compliance to sedation was scored using a pre-existing simple descriptive scale to ensure adequate sedation.

Intervention and Procedures

  • Two treatments were compared:
    • ICE: 5 minutes of applying ice to the skin over the infraorbital canal.
    • N-ICE: No ice applied.
  • An infraorbital nerve block was performed using 5 mL of 2% mepivacaine in both groups.
  • Effectiveness of the block was verified by pricking the area with a 25-gauge needle to test sensation loss.
  • The procedures were video-recorded for unbiased analysis.

Outcome Measures

  • Compliance was measured by two blinded investigators using a Visual Analogue Scale (VAS) ranging from 0 to 10, indicating how well each horse tolerated the block.
  • The two scores per horse (one from each investigator) were summed for a total maximum score of 20.
  • Block success was noted—whether the nerve block effectively anesthetized the area.
  • Any adverse effects linked to icing were recorded.

Results

  • No statistically significant difference in compliance was observed between ICE and N-ICE groups (P = 0.179).
  • Mean combined VAS scores were slightly higher in the ICE group (13.74 ± 6.2) compared to the N-ICE group (11.81 ± 6.9), but this difference was not significant.
  • Block success was higher in the ICE group with 24/30 successful blocks versus 18/30 in the N-ICE group; however, statistical significance was not mentioned.
  • No adverse effects were reported from the application of ice.

Conclusions and Implications

  • Applying ice to the skin over the infraorbital canal before nerve block placement in sedated horses did not significantly improve their compliance during the procedure.
  • While there was a numerical increase in compliance and block success for the ICE group, the differences did not reach statistical significance.
  • No safety concerns were identified with the use of cryotherapy, suggesting it is a safe adjunct but may not provide clear benefit in improving patient tolerance for this procedure.
  • The findings suggest that other methods may be needed to enhance horse compliance during infraorbital nerve blocks.

Cite This Article

APA
Mart S, Flynn H, Barter LS, Pypendop BH, Kilcoyne I, Nelligan K, Fernandez-Barrientos M, Pusterla N. (2026). Investigating the effect of surface cryotherapy on equine patient compliance to infraorbital nerve block placement. Vet Anaesth Analg, 53(3), 101216. https://doi.org/10.1016/j.vaa.2026.101216

Publication

ISSN: 1467-2995
NlmUniqueID: 100956422
Country: United States
Language: English
Volume: 53
Issue: 3
Pages: 101216
PII: S1467-2987(26)00030-9

Researcher Affiliations

Mart, Shane
  • William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Flynn, Harriet
  • Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA. Electronic address: hflynn@ucdavis.edu.
Barter, Linda S
  • Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Pypendop, Bruno H
  • Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Kilcoyne, Isabelle
  • Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Nelligan, Katy
  • William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Fernandez-Barrientos, Manuel
  • William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Pusterla, Nicola
  • Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.

Conflict of Interest Statement

Conflict of interest statement The authors declare no conflict of interest.

Citations

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