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Home / Equine Research Bank / Transbound Emerg Dis / Isolation and Characterization of Madariaga Virus from a Hor...
Transboundary and emerging diseases2015; 64(3); 990-993; doi: 10.1111/tbed.12441

Isolation and Characterization of Madariaga Virus from a Horse in Paraíba State, Brazil.

Abstract: Madariaga virus (MADV), the new species designation for the South American isolates of eastern equine encephalitis virus (EEEV), is genetically divergent and substantially different in ecology and pathogenesis from North American EEEV strains. We isolated and characterized a MADV isolate obtained from a horse in Brazil. Our results support previous phylogenetic studies showing there are three genetically distinct MADV lineages. The MADV isolate from Paraíba State belongs to the South American lineage III and is closely related to Peruvian, Colombian and Venezuelan isolates.
© 2015 Blackwell Verlag GmbH.
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Publication Date: 2015-11-25 PubMed ID: 26608567PubMed Central: PMC4879107DOI: 10.1111/tbed.12441Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research is about the isolation and study of a type of virus called Madariaga virus (MADV), which is a variant of the Eastern Equine Encephalitis virus, from a horse in Paraíba State, Brazil. The researchers were able to identify the strain of the virus and align it to one of its three distinct genetic lineages.

Study Focus and Background

  • The primary focus of this study was to isolate and study the Madariaga virus (MADV) from a horse in Paraíba State, Brazil.
  • MADV is essentially a new species designation for the South American isolates of the Eastern Equine Encephalitis virus (EEEV).
  • EEEV is a dangerous mosquito-borne virus that affects both humans and animals.

MADV Genetic Diversity

  • A major finding in this study is that MADV is genetically distinct and substantially different in terms of ecology and pathogenesis from the North American strains of EEEV.
  • This finding underscores the genetic diversity within the EEEV complex and the need for further studies to understand the behavior and impact of these diverse strains.

Phylogenetic Studies of MADV

  • The research supports previous phylogenetic studies indicating that there are three genetically distinct MADV lineages.
  • Phylogenetic studies analyze hereditary molecular differences, primarily in the DNA sequences, to gain information about an organism’s evolutionary relationships.

Identification of the MADV Strain

  • The MADV strain isolated from the horse in Paraíba State was identified to belong to South American lineage III, indicating a close relation to MADV strains in Peru, Colombia, and Venezuela.
  • This information can be crucial in the development of targeted treatments and interventions for horses and other species infected with this variant of the virus.

Cite This Article

APA
Silva MLCR, Auguste AJ, Terzian ACB, Vedovello D, Riet-Correa F, Macário VMK, Mourão MPG, Ullmann LS, Araújo JP, Weaver SC, Nogueira ML. (2015). Isolation and Characterization of Madariaga Virus from a Horse in Paraíba State, Brazil. Transbound Emerg Dis, 64(3), 990-993. https://doi.org/10.1111/tbed.12441

Publication

Transboundary and emerging diseases
ISSN: 1865-1682
NlmUniqueID: 101319538
Country: Germany
Language: English
Volume: 64
Issue: 3
Pages: 990-993

Researcher Affiliations

Silva, M L C R
  • Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Bolsista DCR/FAPEAM, Manaus, Brazil.
Auguste, A J
  • Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Departments of Pathology, and Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Terzian, A C B
  • Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil.
Vedovello, D
  • Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil.
Riet-Correa, F
  • Centro de Saúde e Tecnologia Rural, Universidade Federal de Campina Grande, Patos, Brazil.
Macário, V M K
  • Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Bolsista DCR/FAPEAM, Manaus, Brazil.
Mourão, M P G
  • Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Bolsista DCR/FAPEAM, Manaus, Brazil.
Ullmann, L S
  • Universidade Estadual Paulista, Botucatu, SP, Brazil.
Araújo, J P
  • Universidade Estadual Paulista, Botucatu, SP, Brazil.
Weaver, S C
  • Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Departments of Pathology, and Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Nogueira, M L
  • Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Bolsista DCR/FAPEAM, Manaus, Brazil.
  • Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil.

MeSH Terms

  • Aedes / cytology
  • Aedes / virology
  • Animals
  • Brain / virology
  • Brazil
  • Cells, Cultured
  • Encephalitis Virus, Eastern Equine / classification
  • Encephalitis Virus, Eastern Equine / genetics
  • Encephalitis Virus, Eastern Equine / isolation & purification
  • Encephalomyelitis, Equine / veterinary
  • Encephalomyelitis, Equine / virology
  • Horse Diseases / virology
  • Horses
  • Mice
  • Phylogeny

Grant Funding

  • HHSN272201000040I / NIAID NIH HHS
  • R01 AI048807 / NIAID NIH HHS
  • R01 AI049725 / NIAID NIH HHS

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Citations

This article has been cited 12 times.
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