Long-term follow-up of Norwegian horses affected with acquired equine polyneuropathy.
Abstract: Acquired equine polyneuropathy (AEP), a neurological disease clinically characterised by knuckling of metatarsophalangeal joints, has been described in numerous Nordic horses during the last 20 years. Although clinical recovery has been reported, large-scale data on long-term follow-up of survivors have been lacking. Objective: To describe long-term survival of AEP affected horses registered in Norway, with a focus on athletic performance and possible residual clinical signs connected to the disease. Methods: A retrospective cohort study. Methods: The study includes 143 horses recorded with AEP in Norway from 2000 to 2012, with the follow-up period continuing until 2015. Participating owners of survivors completed a standardised questionnaire, providing information on disease and convalescence, management, performance-level and possible residual clinical signs. To investigate the follow-up of survivors, we performed 2 multivariable linear regression models. Results: The follow-up time of survivors was 1.0-14.5 years (median 5.3, interquartile range 2.5-7.2). Fifty-seven horses survived and all but 3 horses returned to previous or higher level of performance. However, possible disease-related residual clinical signs were reported in 14/57 horses. Forty-nine of the survivors were in athletic use at time of contact. The majority of survivors were categorised with low severity-grades at time of diagnosis and the initial grade was significantly associated with time to resumed training. Only 3 horses had experienced relapse/new attack during the follow-up period. Conclusions: Athletic performance was judged by owners, which renders a possible source of bias. Conclusions: Although AEP is a potential fatal disease, most survivors will recover and return to minimum previous level of athletic performance. Some horses display residual clinical signs, but often without negative effect on performance and relapse of disease is rare.
© 2017 EVJ Ltd.
Publication Date: 2017-02-27 PubMed ID: 28128873DOI: 10.1111/evj.12674Google Scholar: Lookup
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- Journal Article
- Athletic Horses
- Athletic Performance
- Clinical Signs
- Clinical Study
- Disease Management
- Disease Treatment
- Epidemiology
- Equine Diseases
- Equine Health
- Equine Science
- Horse Owners
- Horses
- Longitudinal Study
- Neurological Diseases
- Performance Horses
- Regression Analysis
- Retrospective Study
- Veterinary Care
- Veterinary Medicine
- Veterinary Research
Summary
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The study traces the recovery of Norwegian horses diagnosed with Acquired Equine Polyneuropathy (AEP) from 2000 to 2015 and highlights that, while AEP is potentially fatal, most survivors can regain or even surpass their previous athletic performance. However, a minority of these horses were reported to exhibit lingering symptoms linked to the disease.
Understanding the Research
- The study primarily focuses on Acquired Equine Polyneuropathy (AEP), a neurological disease affecting horses. It is especially common in Nordic horses and exhibits through knuckling of metatarsophalangeal joints, potentially impeding the horse’s athletic performance.
- The objective of the research is to describe the long-term survival and the performance levels of the horses diagnosed with AEP in Norway, from 2000 to 2012.
- The study also intends to catalog any remaining signs of the disease in survivors and hence provide better understanding about the disease and its long-term impact.
Methods of the Study
- The tracing of the affected horses was carried out through a retrospective cohort study.
- The study tracked 143 Norwegian horses diagnosed with AEP between 2000 and 2012, with the following up period extending till 2015.
- The owners of the surviving horses filled out a standardized questionnaire. The information they supplied encompassed topics such as the history of the disease, its management, the performance level of the animals, and any residual clinical signs.
- Two multivariable linear regression models were generated to assess the follow-up results of survivors.
Main Findings
- The follow-up duration for the surviving horses was between 1 and 14.5 years, with an average of 5.3 years.
- Out of 57 surviving horses, 54 returned to their previous or even higher levels of performance. However, some residual signs of the disease were detected in 14 out of these 57 horses.
- 49 of the surviving horses were still being used for athletic purposes at the time of the study.
- Only 3 out of the 57 horses had recurring or new attacks of AEP during the follow-up period.
Conclusions
- Despite AEP being potentially fatal, most surviving horses were found to recover and return to or exceed their previous level of athletic activity.
- While some horses do exhibit residual clinical signs of the disease, these symptoms often do not have a negative impact on their performance. Furthermore, relapse is very rare.
- However, researchers noted a potential bias in the study as the horse’s athletics performance was judged by their owners.
Cite This Article
APA
Hanche-Olsen S, Kielland C, Ihler CF, Hultin Jäderlund K.
(2017).
Long-term follow-up of Norwegian horses affected with acquired equine polyneuropathy.
Equine Vet J, 49(5), 577-583.
https://doi.org/10.1111/evj.12674 Publication
Researcher Affiliations
- Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway.
- Department of Production Animals, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway.
- Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway.
- Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway.
MeSH Terms
- Animals
- Data Collection
- Disease Outbreaks / veterinary
- Female
- Follow-Up Studies
- Horse Diseases / epidemiology
- Horse Diseases / pathology
- Horses
- Male
- Norway / epidemiology
- Polyneuropathies / epidemiology
- Polyneuropathies / pathology
- Polyneuropathies / veterinary
- Retrospective Studies
Citations
This article has been cited 3 times.- Cahalan SD, Boehm I, Jones RA, Piercy RJ. Recognising the potential of large animals for modelling neuromuscular junction physiology and disease. J Anat 2022 Nov;241(5):1120-1132.
- Björnsdóttir S, Sigurðardóttir ÓG, Oddsdóttir C, Reynisdóttir I, Hanche-Olsen S, Gröndahl G. Outbreak of digital extensor dysfunction compatible with acquired equine polyneuropathy observed for the first time in Iceland. Acta Vet Scand 2025 Nov 26;67(1):50.
- May A, Hanche-Olsen S, Goehring LS, Matiasek K, Jäderlund KH, Zablotski Y, Gröndahl G. Motor pathway evaluation by transcranial magnetic stimulation in Swedish horses with acquired equine polyneuropathy. Equine Vet J 2026 Jan;58(1):115-124.
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