Maturation of the central nervous system: comparison of equine and other species.
Abstract: This review covers the development and maturation of the cerebellum of the horse and compares this developmental sequence with that of man, mouse and chicken. These comparisons attempt to correlate morphological and neurochemical features, developmental time and functional performance necessary for survival at birth. Although there is great disparity between these 3 species, the basic anatomical structures of the cerebellum are present as are specific cellular groups, synapses and neurochemical markers. In addition to this structural homogeneity, other attributes of the cerebellum are its easily identified cellular populations and its well ordered pattern of growth and differentiation. The cerebella of the developing chick and mouse have been studied in great detail as they are amenable to experimental manipulations. The pattern of cellular differentiation appears to be reproducible from species to species and differs primarily as it relates to gestational age and functional requirements at birth. For instance, most of the large neurones of the cerebellar cortex differentiate early with small neurones and neuroglia differentiating later. Neurogenesis of the cerebellar cortex is fairly complete in the newborn foal and chick hatchling, but not in the human or rodent newborn.
Publication Date: 1993-04-01 PubMed ID: 9079134DOI: 10.1111/j.2042-3306.1993.tb04806.xGoogle Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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The research paper discusses a comparative study on the development and maturation of the cerebral cerebellum across different species, specifically focusing on horses, humans, mice, and chickens. The research tracks similarities and disparities in morphological, neurochemical attributes during their development, and their functional performance needed for survival at birth.
Comparative Analysis of Cerebellum Maturation
- The research undertakes a comparative analysis of the cerebellum’s development across different species. The species considered for the study include horses, humans, mice, and chicken. The comparison involves morphological structures, neurochemical features, developmental period, and necessary functional abilities at birth.
Structural Similarities
- Despite the significant disparities amidst these varied species, the research found similar fundamental anatomical structures within the cerebellum. Additionally, specific cellular clusters, synapses, and neurochemical markers were also predominantly identical across these species.
- The cerebellum in all these species also shared features of easily identifiable cellular populations and a consistent pattern of growth and differentiation.
Research of Cerebellum in Mice and Chicken
- Due to their amenability to experimental manipulations, the cerebral cerebellum development in mice and chicken has been extensively studied. These investigations have led to interesting insights which were considered for the research.
Cellular Differentiation in Different Species
- The paper discusses the pattern of cellular differentiation, which appears to be very similar among species but differs according to gestation period and functional birth requirements. For example, the differentiation of large neurons in the cerebellar cortex happens early in all species, whereas smaller neurons and neuroglia differentiate later.
Comparative Neurogenesis
- The research indicates that neurogenesis of the cerebellar cortex is fairly complete in a newborn foal and a chick hatchling. Conversely, this development appears to be incomplete in humans and rodents.
Cite This Article
APA
Sisken BF, Zwick M, Hyde JF, Cottrill CM.
(1993).
Maturation of the central nervous system: comparison of equine and other species.
Equine Vet J Suppl(14), 31-34.
https://doi.org/10.1111/j.2042-3306.1993.tb04806.x Publication
Researcher Affiliations
- Department of Anatomy and Neurobiology, University of Kentucky, Lexington 40536-0084, USA.
MeSH Terms
- Animals
- Animals, Newborn / growth & development
- Cattle
- Cerebellum / embryology
- Cerebellum / growth & development
- Chickens / growth & development
- Embryonic and Fetal Development / physiology
- Horses / embryology
- Horses / growth & development
- Humans
- Immunohistochemistry
- Mice
Citations
This article has been cited 2 times.- Tan HO, Reid CA, Single FN, Davies PJ, Chiu C, Murphy S, Clarke AL, Dibbens L, Krestel H, Mulley JC, Jones MV, Seeburg PH, Sakmann B, Berkovic SF, Sprengel R, Petrou S. Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. Proc Natl Acad Sci U S A 2007 Oct 30;104(44):17536-41.
- Fang M, Zhang L, Li J, Wang C, Chung CH, Wai SM, Yew DT. The postnatal development of the cerebellum- a fMRI and silver study. Cell Mol Neurobiol 2005 Sep;25(6):1043-50.
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