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Home / Equine Research Bank / Animals (Basel) / Measurement of Plasma Resistin Concentrations in Horses with...
Animals : an open access journal from MDPI2021; 12(1); 77; doi: 10.3390/ani12010077

Measurement of Plasma Resistin Concentrations in Horses with Metabolic and Inflammatory Disorders.

Abstract: Obesity and its associated complications, such as metabolic syndrome, are an increasing problem in both humans and horses in the developed world. The expression patterns of resistin differ considerably between species. In rodents, resistin is expressed by adipocytes and is related to obesity and ID. In humans, resistin is predominantly produced by inflammatory cells, and resistin concentrations do not reflect the degree of obesity, although they may predict cardiovascular outcomes. The aim of this study was to investigate the usefulness of resistin and its relationship with ID and selected indicators of inflammation in horses. Seventy-two horses, included in one of the four following groups, were studied: healthy controls (C, n = 14), horses with inflammatory conditions (I, n = 21), horses with mild ID (ID1, n = 18), and horses with severe ID (ID2, n = 19). Plasma resistin concentrations were significantly different between groups and the higher values were recorded in the I and ID2 groups (C: 2.38 ± 1.69 ng/mL; I: 6.85 ± 8.38 ng/mL; ID1: 2.41 ± 2.70 ng/mL; ID2: 4.49 ± 3.08 ng/mL). Plasma resistin was not correlated with basal insulin concentrations. A significant (r = 0.336, = 0.002) correlation was found between resistin and serum amyloid A. Our results show that, as is the case in humans, plasma resistin concentrations in horses are predominantly related to inflammatory conditions and not to ID. Horses with severe ID showed an elevation in resistin that may be secondary to the inflammatory status associated with metabolic syndrome.
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Publication Date: 2021-12-30 PubMed ID: 35011183PubMed Central: PMC8744951DOI: 10.3390/ani12010077Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the concentration of a hormone called resistin in horses suffering from inflammatory and metabolic disorders. The study found that resistin concentrations were higher in horses with inflammation and severe insulin disorder (ID), suggesting the hormone’s potential role in these conditions, similar to humans.

Objective of the Study

  • The primary goal of the research was to explore the role of resistin, a hormone, and its relationship with insulin disorder (ID) and specific inflammation indicators in horses.

Methodology and Participants

  • Sixty-two horses were included in the study, which were divided into four groups: healthy control horses (C), horses with inflammatory conditions (I), horses with mild ID (ID1), and horses with severe ID (ID2).

Significant Findings

  • The study found a significant difference in plasma resistin levels among the groups, with higher values recorded in horses with inflammatory conditions (I group) and severe ID (ID2 group).
  • The resistin concentrations were not correlated with the basic insulin levels. However, researchers found a significant correlation between resistin and serum amyloid A, a major acute-phase protein and a marker of inflammation.

Implication of the Findings

  • Similar to humans, the study suggests that in horses too, resistin concentrations are primarily associated with inflammatory conditions rather than insulin disorder (ID).
  • In horses with severe ID, an increase in resistin may be secondary to the inflammatory status related to metabolic syndrome, a cluster of conditions that increases the risk of heart disease, stroke, and type 2 diabetes.

Significance of the Study

  • The research contributes insight into the role of resistin in horses, which may help in understanding and managing metabolic and inflammatory disorders better.
  • By understanding the correlation between resistin levels, ID, and inflammation, veterinary physicians can potentially create better treatment plans for horses suffering from these conditions.

Cite This Article

APA
Fuentes-Romero B, Muñoz-Prieto A, Cerón JJ, Martín-Cuervo M, Iglesias-García M, Aguilera-Tejero E, Díez-Castro E. (2021). Measurement of Plasma Resistin Concentrations in Horses with Metabolic and Inflammatory Disorders. Animals (Basel), 12(1), 77. https://doi.org/10.3390/ani12010077

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 1
PII: 77

Researcher Affiliations

Fuentes-Romero, Beatriz
  • Department of Equine Internal Medicine, University of Extremadura, 10004 Cáceres, Spain.
Muñoz-Prieto, Alberto
  • Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, University of Murcia, 30003 Murcia, Spain.
Cerón, José J
  • Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, University of Murcia, 30003 Murcia, Spain.
Martín-Cuervo, María
  • Department of Equine Internal Medicine, University of Extremadura, 10004 Cáceres, Spain.
Iglesias-García, Manuel
  • Department of Equine Surgery, University of Extremadura, 10004 Cáceres, Spain.
Aguilera-Tejero, Escolástico
  • Department of Equine Internal Medicine, University of Córdoba, 14014 Córdoba, Spain.
Díez-Castro, Elisa
  • Department of Equine Internal Medicine, University of Córdoba, 14014 Córdoba, Spain.

Conflict of Interest Statement

This study was partially presented as a poster (250 words) at the ECEIM Congress, online 2021. The authors declare no conflict of interest.

References

This article includes 66 references
  1. Ertelt A, Barton AK, Schmitz RR, Gehlen H. Metabolic syndrome: is equine disease comparable to what we know in humans?. Endocr Connect 2014 Sep;3(3):R81-93.
    doi: 10.1530/EC-14-0038pmc: PMC4068110pubmed: 24894908google scholar: lookup
  2. Frank N. Equine metabolic syndrome.. Vet Clin North Am Equine Pract 2011 Apr;27(1):73-92.
    doi: 10.1016/j.cveq.2010.12.004pubmed: 21392655google scholar: lookup
  3. Durham AE, Frank N, McGowan CM, Menzies-Gow NJ, Roelfsema E, Vervuert I, Feige K, Fey K. ECEIM consensus statement on equine metabolic syndrome.. J Vet Intern Med 2019 Mar;33(2):335-349.
    doi: 10.1111/jvim.15423pmc: PMC6430910pubmed: 30724412google scholar: lookup
  4. Frank N, Tadros EM. Insulin dysregulation.. Equine Vet J 2014 Jan;46(1):103-12.
    doi: 10.1111/evj.12169pubmed: 24033478google scholar: lookup
  5. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ.. J Clin Endocrinol Metab 2004 Jun;89(6):2548-56.
    doi: 10.1210/jc.2004-0395pubmed: 15181022google scholar: lookup
  6. Radin MJ, Sharkey LC, Holycross BJ. Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses.. Vet Clin Pathol 2009 Jun;38(2):136-56.
    doi: 10.1111/j.1939-165X.2009.00133.xpubmed: 19392760google scholar: lookup
  7. Lago F, Dieguez C, Gómez-Reino J, Gualillo O. Adipokines as emerging mediators of immune response and inflammation.. Nat Clin Pract Rheumatol 2007 Dec;3(12):716-24.
    doi: 10.1038/ncprheum0674pubmed: 18037931google scholar: lookup
  8. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes.. J Clin Invest 2005 May;115(5):1111-9.
    doi: 10.1172/JCI25102pmc: PMC1087185pubmed: 15864338google scholar: lookup
  9. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes.. Nature 2001 Jan 18;409(6818):307-12.
    doi: 10.1038/35053000pubmed: 11201732google scholar: lookup
  10. Steppan CM, Lazar MA. The current biology of resistin.. J Intern Med 2004 Apr;255(4):439-47.
    doi: 10.1111/j.1365-2796.2004.01306.xpubmed: 15049878google scholar: lookup
  11. Kojta I, Chacińska M, Błachnio-Zabielska A. Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance.. Nutrients 2020 May 3;12(5).
    doi: 10.3390/nህ1305pmc: PMC7284998pubmed: 32375231google scholar: lookup
  12. Taouis M, Benomar Y. Is resistin the master link between inflammation and inflammation-related chronic diseases?. Mol Cell Endocrinol 2021 Aug 1;533:111341.
    doi: 10.1016/j.mce.2021.111341pubmed: 34082045google scholar: lookup
  13. Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C, Macphee CH, Smith SA. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators.. Biochem Biophys Res Commun 2003 Jan 10;300(2):472-6.
    doi: 10.1016/S0006-291X(02)02841-3pubmed: 12504108google scholar: lookup
  14. Barnes KM, Miner JL. Role of resistin in insulin sensitivity in rodents and humans.. Curr Protein Pept Sci 2009 Feb;10(1):96-107.
    doi: 10.2174/138920309787315239pubmed: 19275676google scholar: lookup
  15. Amirhakimi A, Karamifar H, Moravej H, Amirhakimi G. Serum resistin level in obese male children.. J Obes 2011;2011:953410.
    doi: 10.1155/2011/953410pmc: PMC3092673pubmed: 21603279google scholar: lookup
  16. Boyraz M, Cekmez F, Karaoğlu A, Cinaz P, Durak M, Bideci A. Relationship of adipokines (adiponectin, resistin and RBP4) with metabolic syndrome components in pubertal obese children.. Biomark Med 2013 Jun;7(3):423-8.
    doi: 10.2217/bmm.13.14pubmed: 23734806google scholar: lookup
  17. Gerber M, Boettner A, Seidel B, Lammert A, Bär J, Schuster E, Thiery J, Kiess W, Kratzsch J. Serum resistin levels of obese and lean children and adolescents: biochemical analysis and clinical relevance.. J Clin Endocrinol Metab 2005 Aug;90(8):4503-9.
    doi: 10.1210/jc.2005-0437pubmed: 15928242google scholar: lookup
  18. Park HK, Ahima RS. Resistin in rodents and humans.. Diabetes Metab J 2013 Dec;37(6):404-14.
    doi: 10.4093/dmj.2013.37.6.404pmc: PMC3881324pubmed: 24404511google scholar: lookup
  19. Park HK, Kwak MK, Kim HJ, Ahima RS. Linking resistin, inflammation, and cardiometabolic diseases.. Korean J Intern Med 2017 Mar;32(2):239-247.
    doi: 10.3904/kjim.2016.229pmc: PMC5339472pubmed: 28192887google scholar: lookup
  20. Su KZ, Li YR, Zhang D, Yuan JH, Zhang CS, Liu Y, Song LM, Lin Q, Li MW, Dong J. Relation of Circulating Resistin to Insulin Resistance in Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis.. Front Physiol 2019;10:1399.
    doi: 10.3389/fphys.2019.01399pmc: PMC6877503pubmed: 31803062google scholar: lookup
  21. Komatsu T, Itoh F, Mikawa S, Hodate K. Gene expression of resistin in adipose tissue and mammary gland of lactating and non-lactating cows.. J Endocrinol 2003 Sep;178(3):R1-5.
    doi: 10.1677/joe.0.178r001pubmed: 12967346google scholar: lookup
  22. Dai MH, Xia T, Chen XD, Gan L, Feng SQ, Qiu H, Peng Y, Yang ZQ. Cloning and characterization of porcine resistin gene.. Domest Anim Endocrinol 2006 Feb;30(2):88-97.
    doi: 10.1016/j.domaniend.2005.06.003pubmed: 16023825google scholar: lookup
  23. Takashima S, Nishii N, Kobatake Y, Kiyosue M, Kimura S, Kitagawa H. Concentrations of leptin, adiponectin, and resistin in the serum of obese cats during weight loss.. J Vet Med Sci 2019 Sep 18;81(9):1294-1300.
    doi: 10.1292/jvms.19-0091pmc: PMC6785622pubmed: 31366817google scholar: lookup
  24. Reverchon M, Ramé C, Cognié J, Briant E, Elis S, Guillaume D, Dupont J. Resistin in dairy cows: plasma concentrations during early lactation, expression and potential role in adipose tissue.. PLoS One 2014;9(3):e93198.
    doi: 10.1371/journal.pone.0093198pmc: PMC3968062pubmed: 24675707google scholar: lookup
  25. Mellouk N, Rame C, Touzé JL, Briant E, Ma L, Guillaume D, Lomet D, Caraty A, Ntallaris T, Humblot P, Dupont J. Involvement of plasma adipokines in metabolic and reproductive parameters in Holstein dairy cows fed with diets with differing energy levels.. J Dairy Sci 2017 Oct;100(10):8518-8533.
    doi: 10.3168/jds.2017-12657pubmed: 28803009google scholar: lookup
  26. Weber M, Locher L, Huber K, Kenéz Á, Rehage J, Tienken R, Meyer U, Dänicke S, Sauerwein H, Mielenz M. Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation. Part 1: The adipokines apelin and resistin and their relationship to receptors linked with lipolysis.. J Dairy Sci 2016 Feb;99(2):1549-1559.
    doi: 10.3168/jds.2015-10131pubmed: 26686707google scholar: lookup
  27. Guzel S, Belenli D. The interrelationship between resistin and amylin plasma concentrations and their relation to the concentrations of selected reproductive and metabolic hormones and biochemical variables in the early lactation stage of Saanen goats. Rev. Med. Vet. 2015;166:229–233.
  28. Johnson PJ. The equine metabolic syndrome peripheral Cushing's syndrome.. Vet Clin North Am Equine Pract 2002 Aug;18(2):271-93.
    doi: 10.1016/S0749-0739(02)00006-8pubmed: 15635908google scholar: lookup
  29. Staub C, Venturi E, Cirot M, Léonard L, Barrière P, Blard T, Gaudé Y, Gascogne T, Yvon JM, Lecompte F, Ramé C, Reigner F, Dupont J. Ultrasonographic measures of body fatness and their relationship with plasma levels and adipose tissue expression of four adipokines in Welsh pony mares.. Domest Anim Endocrinol 2019 Oct;69:75-83.
    doi: 10.1016/j.domaniend.2019.02.002pubmed: 31374538google scholar: lookup
  30. Henneke DR, Potter GD, Kreider JL, Yeates BF. Relationship between condition score, physical measurements and body fat percentage in mares.. Equine Vet J 1983 Oct;15(4):371-2.
    doi: 10.1111/j.2042-3306.1983.tb01826.xpubmed: 6641685google scholar: lookup
  31. Carter RA, Geor RJ, Burton Staniar W, Cubitt TA, Harris PA. Apparent adiposity assessed by standardised scoring systems and morphometric measurements in horses and ponies.. Vet J 2009 Feb;179(2):204-10.
    doi: 10.1016/j.tvjl.2008.02.029pubmed: 18440844google scholar: lookup
  32. Frank N, Bailey S R, Bertin F R, De Laat M A, Durham A E, Kritchevsky J, Menzies-Gow N J. Recommendations for the Diagnosis and Treatment of Equine Metabolic Syndrome (EMS). .
  33. Jocelyn NA, Harris PA, Menzies-Gow NJ. Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test.. Equine Vet J 2018 Nov;50(6):836-841.
    doi: 10.1111/evj.12826pubmed: 29504630google scholar: lookup
  34. Warnken T, Huber K, Feige K. Comparison of three different methods for the quantification of equine insulin.. BMC Vet Res 2016 Sep 9;12(1):196.
    doi: 10.1186/s12917-016-0828-zpmc: PMC5016943pubmed: 27613127google scholar: lookup
  35. Jamaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease.. Br J Pharmacol 2012 Feb;165(3):622-32.
    doi: 10.1111/j.1476-5381.2011.01369.xpmc: PMC3315035pubmed: 21545576google scholar: lookup
  36. Derosa G, Fogari E, D'Angelo A, Bianchi L, Bonaventura A, Romano D, Maffioli P. Adipocytokine levels in obese and non-obese subjects: an observational study.. Inflammation 2013 Aug;36(4):914-20.
    doi: 10.1007/s10753-013-9620-4pubmed: 23467997google scholar: lookup
  37. Takahashi H, Tsuji H, Ishida-Yamamoto A, Iizuka H. Serum level of adiponectin increases and those of leptin and resistin decrease following the treatment of psoriasis.. J Dermatol 2013 Jun;40(6):475-6.
    doi: 10.1111/1346-8138.12122pubmed: 23488663google scholar: lookup
  38. Koch A, Gressner OA, Sanson E, Tacke F, Trautwein C. Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients.. Crit Care 2009;13(3):R95.
    doi: 10.1186/cc7925pmc: PMC2717467pubmed: 19545363google scholar: lookup
  39. Sundén-Cullberg J, Nyström T, Lee ML, Mullins GE, Tokics L, Andersson J, Norrby-Teglund A, Treutiger CJ. Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock.. Crit Care Med 2007 Jun;35(6):1536-42.
    doi: 10.1097/01.CCM.0000266536.14736.03pubmed: 17452927google scholar: lookup
  40. Tripathi D, Kant S, Pandey S, Ehtesham NZ. Resistin in metabolism, inflammation, and disease.. FEBS J 2020 Aug;287(15):3141-3149.
    doi: 10.1111/febs.15322pubmed: 32255270google scholar: lookup
  41. Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H, Patsch JR. Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro.. Biochem Biophys Res Commun 2003 Sep 19;309(2):286-90.
    doi: 10.1016/j.bbrc.2003.07.003pubmed: 12951047google scholar: lookup
  42. Codoñer-Franch P, Alonso-Iglesias E. Resistin: insulin resistance to malignancy.. Clin Chim Acta 2015 Jan 1;438:46-54.
    doi: 10.1016/j.cca.2014.07.043pubmed: 25128719google scholar: lookup
  43. Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, Lazar MA. An inflammatory cascade leading to hyperresistinemia in humans.. PLoS Med 2004 Nov;1(2):e45.
    doi: 10.1371/journal.pmed.0010045pmc: PMC529430pubmed: 15578112google scholar: lookup
  44. Anderson PD, Mehta NN, Wolfe ML, Hinkle CC, Pruscino L, Comiskey LL, Tabita-Martinez J, Sellers KF, Rickels MR, Ahima RS, Reilly MP. Innate immunity modulates adipokines in humans.. J Clin Endocrinol Metab 2007 Jun;92(6):2272-9.
    doi: 10.1210/jc.2006-2545pubmed: 17374708google scholar: lookup
  45. Schwartz DR, Lazar MA. Human resistin: found in translation from mouse to man.. Trends Endocrinol Metab 2011 Jul;22(7):259-65.
    doi: 10.1016/j.tem.2011.03.005pmc: PMC3130099pubmed: 21497511google scholar: lookup
  46. Pine GM, Batugedara HM, Nair MG. Here, there and everywhere: Resistin-like molecules in infection, inflammation, and metabolic disorders.. Cytokine 2018 Oct;110:442-451.
    doi: 10.1016/j.cyto.2018.05.014pmc: PMC6103837pubmed: 29866514google scholar: lookup
  47. Huang X, Yang Z. Resistin's, obesity and insulin resistance: the continuing disconnect between rodents and humans.. J Endocrinol Invest 2016 Jun;39(6):607-15.
    doi: 10.1007/s40618-015-0408-2pubmed: 26662574google scholar: lookup
  48. Filková M, Haluzík M, Gay S, Senolt L. The role of resistin as a regulator of inflammation: Implications for various human pathologies.. Clin Immunol 2009 Nov;133(2):157-70.
    doi: 10.1016/j.clim.2009.07.013pubmed: 19740705google scholar: lookup
  49. Calabrò P, Golia E, Maddaloni V, Malvezzi M, Casillo B, Marotta C, Calabrò R, Golino P. Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?. Intern Emerg Med 2009 Feb;4(1):25-34.
    doi: 10.1007/s11739-008-0207-2pubmed: 19052701google scholar: lookup
  50. Jamaluddin MS, Yan S, Lü J, Liang Z, Yao Q, Chen C. Resistin increases monolayer permeability of human coronary artery endothelial cells.. PLoS One 2013;8(12):e84576.
    doi: 10.1371/journal.pone.0084576pmc: PMC3874001pubmed: 24386395google scholar: lookup
  51. Utzschneider KM, Carr DB, Tong J, Wallace TM, Hull RL, Zraika S, Xiao Q, Mistry JS, Retzlaff BM, Knopp RH, Kahn SE. Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans.. Diabetologia 2005 Nov;48(11):2330-3.
    doi: 10.1007/s00125-005-1932-ypubmed: 16143861google scholar: lookup
  52. Højbjerre L, Sonne MP, Alibegovic AC, Nielsen NB, Dela F, Vaag A, Bruun JM, Stallknecht B. Impact of physical inactivity on adipose tissue low-grade inflammation in first-degree relatives of type 2 diabetic patients.. Diabetes Care 2011 Oct;34(10):2265-72.
    doi: 10.2337/dc11-0631pmc: PMC3177724pubmed: 21836102google scholar: lookup
  53. Janke J, Engeli S, Gorzelniak K, Luft FC, Sharma AM. Resistin gene expression in human adipocytes is not related to insulin resistance.. Obes Res 2002 Jan;10(1):1-5.
    doi: 10.1038/oby.2002.1pubmed: 11786595google scholar: lookup
  54. Al-Harithy RN, Al-Ghamdi S. Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus.. Ann Saudi Med 2005 Jul-Aug;25(4):283-7.
    doi: 10.5144/0256-4947.2005.283pmc: PMC6148019pubmed: 16212119google scholar: lookup
  55. Zaidi SI, Shirwany TA. RELATIONSHIP OF SERUM RESISTIN WITH INSULIN RESISTANCE AND OBESITY.. J Ayub Med Coll Abbottabad 2015 Jul-Sep;27(3):552-5.
    pubmed: 26721005
  56. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity.. Annu Rev Immunol 2011;29:415-45.
    doi: 10.1146/annurev-immunol-031210-101322pubmed: 21219177google scholar: lookup
  57. Pleasant RS, Suagee JK, Thatcher CD, Elvinger F, Geor RJ. Adiposity, plasma insulin, leptin, lipids, and oxidative stress in mature light breed horses.. J Vet Intern Med 2013 May-Jun;27(3):576-82.
    doi: 10.1111/jvim.12056pubmed: 23517373google scholar: lookup
  58. Suagee JK, Corl BA, Crisman MV, Hulver MW, McCutcheon LJ, Geor RJ. Effects of acute hyperinsulinemia on inflammatory proteins in horses.. Vet Immunol Immunopathol 2011 Aug 15;142(3-4):141-6.
    doi: 10.1016/j.vetimm.2011.05.001pubmed: 21621276google scholar: lookup
  59. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity.. J Clin Endocrinol Metab 2008 Nov;93(11 Suppl 1):S64-73.
    doi: 10.1210/jc.2008-1613pmc: PMC2585759pubmed: 18987272google scholar: lookup
  60. Iqbal N, Seshadri P, Stern L, Loh J, Kundu S, Jafar T, Samaha FF. Serum resistin is not associated with obesity or insulin resistance in humans.. Eur Rev Med Pharmacol Sci 2005 May-Jun;9(3):161-5.
    pubmed: 16080635
  61. Azzam E Z, Elneily D, Elgayar N, Elfatatry A, Saad M. Serum levels of resistin and its relationship with some pro-inflammatory cytokines in a cohort of Egyptian patients with Alzheimer’s disease. Endocr. Metab. Sci. 2020;1:100054.
    doi: 10.1016/j.endmts.2020.100054google scholar: lookup
  62. De Luis DA, González Sagrado M, Conde R, Aller R, Izaola O. Resistin levels and inflammatory markers in patients with morbid obesity.. Nutr Hosp 2010 Jul-Aug;25(4):630-4.
    doi: 10.3305/nh.2010.25.4.4478pubmed: 20694300google scholar: lookup
  63. Melone M, Wilsie L, Palyha O, Strack A, Rashid S. Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin/kexin type 9.. J Am Coll Cardiol 2012 May 8;59(19):1697-705.
    doi: 10.1016/j.jacc.2011.11.064pubmed: 22554600google scholar: lookup
  64. Niu XH, Li L, Li JY, Song Q, Jin MM, Liu JX. Serum resistin positively correlates with serum lipids, but not with insulin resistance, in first-degree relatives of type-2 diabetes patients: an observational study in China.. Medicine (Baltimore) 2017 Apr;96(16):e6622.
    doi: 10.1097/MD.0000000000006622pmc: PMC5406073pubmed: 28422857google scholar: lookup
  65. Costandi J, Melone M, Zhao A, Rashid S. Human resistin stimulates hepatic overproduction of atherogenic ApoB-containing lipoprotein particles by enhancing ApoB stability and impairing intracellular insulin signaling.. Circ Res 2011 Mar 18;108(6):727-42.
    doi: 10.1161/CIRCRESAHA.110.238949pubmed: 21293001google scholar: lookup
  66. Cappai MG, Lunesu MG, Accioni F, Liscia M, Pusceddu M, Burrai L, Nieddu M, Dimauro C, Boatto G, Pinna W. Blood serum retinol levels in Asinara white donkeys reflect albinism-induced metabolic adaptation to photoperiod at Mediterranean latitudes.. Ecol Evol 2017 Jan;7(1):390-398.
    doi: 10.1002/ece3.2613pmc: PMC5216663pubmed: 28070301google scholar: lookup

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