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Animals : an open access journal from MDPI2025; 15(3); doi: 10.3390/ani15030310

Molecular Assessment of Plasma Concentrations of Selected Adipokines and IL-8 in Horses with Back Pain and Comorbid Asthma-Based on Clinical Cases.

Abstract: Similarly, in humans and horses, thoracic and lumbosacral back pain cause more disability and work interruptions worldwide than any other disease. Given that there are few effective treatments for back pain in humans and animals, primary prevention strategies and a reduction in pain factors may be crucial. In the analysed data obtained for the horses studied, the pattern of changes in adipocytokine concentrations, including resistin, visfatin and leptin, was noted for those with back pain compared to the control animals. Concentrations of selected adipocytokines in horses from the back pain group were different in animals with a coexisting diagnosis of asthma and back dysfunction. Very few studies are available on adipokine concentrations in horses. No information was found in relation to back pain and asthma in these animals. In humans, correlations of back pain and asthma with concentrations of selected adipokines have been described.
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Publication Date: 2025-01-22 PubMed ID: 39943080PubMed Central: PMC11815831DOI: 10.3390/ani15030310Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research studied the concentration of certain adipokines, including resistin, visfatin and leptin, in horses suffering from back pain and those with comorbid asthma. The research found that such concentrations were different in horses with both conditions compared to the control group.

Objective of the Research

  1. This research was aimed at studying the molecular changes in horses suffering from back pain and those suffering from both back pain and asthma. It specifically focused on the changes in plasma concentrations of selected Adipokines, in particular, resistin, visfatin and leptin, and IL-8 in these horses.

Background Investigation

  1. The premise of this study was that both in humans and horses, back pain in the thoracic and lumbosacral regions can cause notable disability and work interruptions, more than any other diseases globally. Furthermore, treatment options for back pain in either species are limited, making the identification of primary prevention strategies and understanding pain factors paramount.

Results

  1. The study discovered that there is a notable change in the concentration of adipocytokines, specifically resistin, visfatin and leptin in horses with back pain compared to those without.
  2. Interestingly, the concentrations of these adipocytokines in horses afflicted by both back pain and asthma were different from those with only back pain.

Gap in Literature

  1. The paper also highlights the limited availability of studies carried out on the concentration of adipokines in horses.
  2. The paper also states that no studies were found in relation to the correlation between back pain and asthma in horses and the concentration of specific adipokines. However, in a human-sample study, a correlation was found between the two.

Cite This Article

APA
Nowicka B, Polkowska I, Zeliszewska-Duk P, Torres A, Duk M. (2025). Molecular Assessment of Plasma Concentrations of Selected Adipokines and IL-8 in Horses with Back Pain and Comorbid Asthma-Based on Clinical Cases. Animals (Basel), 15(3). https://doi.org/10.3390/ani15030310

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 15
Issue: 3

Researcher Affiliations

Nowicka, Beata
  • Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, Głęboka 30, 20-612 Lublin, Poland.
Polkowska, Izabela
  • Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, Głęboka 30, 20-612 Lublin, Poland.
Zeliszewska-Duk, Paulina
  • Department of Horse Breeding and Use, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland.
Torres, Anna
  • Department of Pediatrics and Adolescent Gynecology, Medical University of Lublin, Chodzki 4, 20-093 Lublin, Poland.
Duk, Mariusz
  • Department of Electronics and Information Technology, Faculty of Electrical Engineering and Computer Science, Lublin University of Technology, 20-618 Lublin, Poland.

Conflict of Interest Statement

The authors declare no conflicts of interest.

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