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The Veterinary clinics of North America. Equine practice2016; 32(2); 229-247; doi: 10.1016/j.cveq.2016.04.003

Musculoskeletal Disease in Aged Horses and Its Management.

Abstract: Musculoskeletal disorders are the most prevalent health problem in aging horses. They are not life threatening, but are painful and an important welfare issue. Chronic joint disease (osteoarthritis) and chronic laminitis are the most prevalent. Treating osteoarthritis in the elderly horse is similar to treating performance horses, but aims at providing a stable situation with optimal comfort. Immediate medical treatment of flare-ups, long-term pain management, and adaptation of exercise and living conditions are the mainstays of treatment. Laminitis in the geriatric horse is related often to pituitary pars intermedia dysfunction, which may be treated with additional pergolide.
Publication Date: 2016-07-28 PubMed ID: 27449390DOI: 10.1016/j.cveq.2016.04.003Google Scholar: Lookup
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Summary

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The research article is about the common musculoskeletal disorders in aged horses and how they are managed. The study mainly focuses on osteoarthritis and chronic laminitis, discussing in detail the treatment and preventive measures for these conditions.

Musculoskeletal Disorders in Aging Horses

  • The researchers initially introduce the significant health issue in aged horses, which is the prevalence of musculoskeletal disorders such as chronic joint disease (osteoarthritis) and chronic laminitis.
  • While these disorders do not directly endanger the horse’s life, they are associated with considerable pain, influencing the overall welfare of the horses. Such conditions also become more prevalent as the horse ages.

Osteoarthritis Treatment in Elderly Horses

  • The paper further delves into the treatment regimen for osteoarthritis in aged horses, which largely mirrors that for performance horses.
  • The primary goal of the treatment is to stabilize the condition while ensuring maximum comfort for the horse.
  • The treatment approach involves immediate medical attention during flare-ups, long-term pain management, and modifications in exercise routines and living conditions.

Laminitis and Its Association with Pituitary Dysfunction

  • Laminitis in elder horses, according to the research, is often linked to pituitary pars intermedia dysfunction. This pituitary dysfunction is a common endocrine disorder in horses causing them to have hormonal imbalances, which can lead to many health problems, including laminitis.
  • The research discusses how the use of pergolide, a medication often used to manage symptoms of Parkinson’s disease in humans, may be beneficial as a supplemental treatment for horses with laminitis associated with pituitary pars intermedia dysfunction.

Cite This Article

APA
van Weeren PR, Back W. (2016). Musculoskeletal Disease in Aged Horses and Its Management. Vet Clin North Am Equine Pract, 32(2), 229-247. https://doi.org/10.1016/j.cveq.2016.04.003

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 32
Issue: 2
Pages: 229-247
PII: S0749-0739(16)30003-7

Researcher Affiliations

van Weeren, Paul René
  • Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584CM Utrecht, the Netherlands. Electronic address: R.VANWEEREN@UU.NL.
Back, Willem
  • Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584CM Utrecht, the Netherlands; Department of Surgery and Anaesthesiology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9280 Merelbeke, Belgium.

MeSH Terms

  • Aging
  • Animals
  • Foot Diseases / therapy
  • Foot Diseases / veterinary
  • Hoof and Claw
  • Horse Diseases / therapy
  • Horses
  • Lameness, Animal
  • Musculoskeletal Diseases / therapy
  • Musculoskeletal Diseases / veterinary
  • Veterinary Medicine

Citations

This article has been cited 25 times.
  1. Torres-Torrillas M, Damia E, Del Romero A, Pelaez P, Miguel-Pastor L, Chicharro D, Carrillo JM, Rubio M, Sopena JJ. Intra-osseous plasma rich in growth factors enhances cartilage and subchondral bone regeneration in rabbits with acute full thickness chondral defects: Histological assessment. Front Vet Sci 2023;10:1131666.
    doi: 10.3389/fvets.2023.1131666pubmed: 37065219google scholar: lookup
  2. Mayet A, Zablotski Y, Roth SP, Brehm W, Troillet A. Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis. Front Vet Sci 2023;10:1125695.
    doi: 10.3389/fvets.2023.1125695pubmed: 36908512google scholar: lookup
  3. Moccia V, Sammarco A, Cavicchioli L, Castagnaro M, Bongiovanni L, Zappulli V. Extracellular Vesicles in Veterinary Medicine. Animals (Basel) 2022 Oct 10;12(19).
    doi: 10.3390/ani12192716pubmed: 36230457google scholar: lookup
  4. Baccarin RYA, Seidel SRT, Michelacci YM, Tokawa PKA, Oliveira TM. Osteoarthritis: a common disease that should be avoided in the athletic horse's life. Anim Front 2022 Jun;12(3):25-36.
    doi: 10.1093/af/vfac026pubmed: 35711506google scholar: lookup
  5. Kelemen Z, Grimm H, Long M, Auer U, Jenner F. Recumbency as an Equine Welfare Indicator in Geriatric Horses and Horses with Chronic Orthopaedic Disease. Animals (Basel) 2021 Nov 8;11(11).
    doi: 10.3390/ani11113189pubmed: 34827921google scholar: lookup
  6. Ribitsch I, Oreff GL, Jenner F. Regenerative Medicine for Equine Musculoskeletal Diseases. Animals (Basel) 2021 Jan 19;11(1).
    doi: 10.3390/ani11010234pubmed: 33477808google scholar: lookup
  7. Ribitsch I, Baptista PM, Lange-Consiglio A, Melotti L, Patruno M, Jenner F, Schnabl-Feichter E, Dutton LC, Connolly DJ, van Steenbeek FG, Dudhia J, Penning LC. Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do. Front Bioeng Biotechnol 2020;8:972.
    doi: 10.3389/fbioe.2020.00972pubmed: 32903631google scholar: lookup
  8. Gencoglu H, Orhan C, Sahin E, Sahin K. Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. Animals (Basel) 2020 Apr 17;10(4).
    doi: 10.3390/ani10040697pubmed: 32316397google scholar: lookup
  9. De Santis M, Contalbrigo L, Borgi M, Cirulli F, Luzi F, Redaelli V, Stefani A, Toson M, Odore R, Vercelli C, Valle E, Farina L. Equine Assisted Interventions (EAIs): Methodological Considerations for Stress Assessment in Horses. Vet Sci 2017 Sep 8;4(3).
    doi: 10.3390/vetsci4030044pubmed: 29056702google scholar: lookup
  10. Graide H, Duysens J, Frank T, Mouithys-Mickalad A, Niesten A, Sandersen C, Ceusters J, Serteyn D. A Simplified 3D-Plasma Culture Method for Generating Minimally Manipulated Autologous Equine Muscle-Derived Progenitor Cells. Bio Protoc 2025 Dec 5;15(23):e5526.
    doi: 10.21769/BioProtoc.5526pubmed: 41384097google scholar: lookup
  11. Smith R, Perkins L, Pinchbeck G, Ireland J. Owners' everyday interactions with their horse: Pain-related issues and those of veterinary concern. Anim Welf 2025;34:e62.
    doi: 10.1017/awf.2025.10036pubmed: 40988863google scholar: lookup
  12. Amari M, Brioschi FA, Auletta L, Ravasio G. Ultrasound-Guided Radiofrequency Ablation and Pulsed Radiofrequency Treatment for Chronic Lameness Due to Distal Forelimb Disease in Horses: A Pilot Study. Animals (Basel) 2025 Aug 10;15(16).
    doi: 10.3390/ani15162341pubmed: 40867669google scholar: lookup
  13. Euppayo T, Siengdee P, Limlenglert P, Nganvongpanit K, Watanabe G, Kasashima Y, Arai K. In vitro model of equine cartilage degradation; using cartilage pellets differentiated from bone marrow-derived mesenchymal stem cells. In Vitro Cell Dev Biol Anim 2025 Jun;61(6):694-702.
    doi: 10.1007/s11626-025-01049-8pubmed: 40425901google scholar: lookup
  14. Luque RM, Henderson B, McCorkell TC, Alizadeh AH, Russell KA, Koch TG, Koenig J. Treatment outcomes for equine osteoarthritis with mesenchymal stromal cells and hyaluronic acid. Equine Vet J 2025 Sep;57(5):1245-1254.
    doi: 10.1111/evj.14531pubmed: 40364589google scholar: lookup
  15. Davis EL, Wood AD, Potier JFN. Prevalence and Progression of Resting ACTH, Insulin and Adiponectin Values as Indicators of Suspected Endocrine Diseases in Sport Horses and Ponies Compared to Non-Sport Horses, Ponies and Donkeys. Animals (Basel) 2025 May 1;15(9).
    doi: 10.3390/ani15091316pubmed: 40362130google scholar: lookup
  16. Secor EJ, Womack SJ, Ysebaert MP, Colville MJ, Reesink HL. Synovial fluid alpha-2-macroglobulin, gelsolin and lubricin distinguish between osteoarthritic and healthy equine joints. Equine Vet J 2026 Jan;58(1):49-59.
    doi: 10.1111/evj.14511pubmed: 40342270google scholar: lookup
  17. Buzelato Carli I, Fielding L. Long-Term Firocoxib Use in Horses. J Vet Intern Med 2025 May-Jun;39(3):e70117.
    doi: 10.1111/jvim.70117pubmed: 40317502google scholar: lookup
  18. Ajeeb B, Kiyotake EA, Keefe PA, Phillips JN, Hatzel JN, Goodrich LR, Detamore MS. Comparison of the chondrogenic potential of eBMSCs and eUCMSCs in response to selected peptides and compounds. BMC Vet Res 2025 Feb 17;21(1):70.
    doi: 10.1186/s12917-024-04448-3pubmed: 39956895google scholar: lookup
  19. Williams ZJ, Chow L, Dow S, Pezzanite LM. The potential for senotherapy as a novel approach to extend life quality in veterinary medicine. Front Vet Sci 2024;11:1369153.
    doi: 10.3389/fvets.2024.1369153pubmed: 38812556google scholar: lookup
  20. Colville MJ, Huang LT, Schmidt S, Chen K, Vishwanath K, Su J, Williams RM, Bonassar LJ, Reesink HL, Paszek MJ. Recombinant manufacturing of multispecies biolubricants. bioRxiv 2024 May 5;.
    doi: 10.1101/2024.05.05.592580pubmed: 38746339google scholar: lookup
  21. de Melo LF, Almeida GHDR, Azarias FR, Carreira ACO, Astolfi-Ferreira C, Ferreira AJP, Pereira ESBM, Pomini KT, Marques de Castro MV, Silva LMD, Maria DA, Rici REG. Decellularized Bovine Skeletal Muscle Scaffolds: Structural Characterization and Preliminary Cytocompatibility Evaluation. Cells 2024 Apr 16;13(8).
    doi: 10.3390/cells13080688pubmed: 38667303google scholar: lookup
  22. Auer U, Kelemen Z, Vogl C, von Ritgen S, Haddad R, Torres Borda L, Gabmaier C, Breteler J, Jenner F. Development, refinement, and validation of an equine musculoskeletal pain scale. Front Pain Res (Lausanne) 2023;4:1292299.
    doi: 10.3389/fpain.2023.1292299pubmed: 38312997google scholar: lookup
  23. Howard DL, Lancaster B, de Grauw J. Development and Preliminary Validation of an Equine Brief Pain Inventory for Owner Assessment of Chronic Pain Due to Osteoarthritis in Horses. Animals (Basel) 2024 Jan 5;14(2).
    doi: 10.3390/ani14020181pubmed: 38254349google scholar: lookup
  24. Pérez Fraile A, González-Cubero E, Martínez-Flórez S, Olivera ER, Villar-Suárez V. Regenerative Medicine Applied to Musculoskeletal Diseases in Equines: A Systematic Review. Vet Sci 2023 Nov 23;10(12).
    doi: 10.3390/vetsci10120666pubmed: 38133217google scholar: lookup
  25. Sazzad F, Kollengode R, Beverly CLX, Kiat TY, Ganesh G, Kofidis T. Preclinical Large Animal In-Vivo Experiments for Surgically Implanted Atrioventricular Valve: Reappraisal and Systematic Review. Curr Cardiol Rev 2023;19(1):e170622206130.