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Home / Equine Research Bank / J Orthop Res / “One Health” in tendinopathy research: Current c...
Journal of orthopaedic research : official publication of the Orthopaedic Research Society2021; 39(8); 1596-1602; doi: 10.1002/jor.25035

“One Health” in tendinopathy research: Current concepts.

Abstract: Tendinopathy remains one of the most common musculoskeletal disorders affecting both human and equine athletes and presents a considerable therapeutic challenge. The following workshop report comes from the third Dorothy Havemeyer Symposium of Tendinopathy which provided a unique overview of our current understanding of both the basic science and the clinical challenges for diagnosing and treating tendinopathy in both species. Pathologically, tendon demonstrates alterations in both cellular, molecular, structural, and biomechanical features, leading to a spectrum of pathological endotypes. To develop novel interventions to manage, treat or prevent tendinopathies it is vital to understand the underlying mechanisms that lead to both tendon failure, and also regeneration and resolution of inflammation. The horse shows analogous pathology with both human Achilles tendinopathy (superficial digital flexor tendon) and intrathecal rotator cuff tears (deep digital flexor tendon tears) enabling scientists and clinicians from both medical and veterinary fields to work jointly on matching naturally occurring disease models. The experience in human medicine on the design, conduct, and impact of clinical trials has much to inform clinical trials in horses. There is a need to design appropriate studies to address clear questions, socialize the study to achieve good enrollment, and consider the significance and impact of the clinical question as well as the cost of addressing it. Because economics is often a limitation in equine medicine the use of observational studies, and specifically registries, should be given careful consideration.
© 2021 Orthopaedic Research Society. Published by Wiley Periodicals LLC.
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Publication Date: 2021-04-02 PubMed ID: 33713481DOI: 10.1002/jor.25035Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the challenges, current understanding, and future directions of tendinopathy research, with a focus on similarity between human and equine athletes. It emphasizes the importance of collaboration between the medical and veterinary fields to create novel interventions for tendinopathy conditions.

Overview of Tendinopathy

  • Tendinopathy is a common musculoskeletal disorder that affects both human and equine athletes. This condition presents a significant therapeutic challenge due to variations in cellular, molecular, structural, and biomechanical features in tendon demonstrations.

Dorothy Havemeyer Symposium Content

  • The third Dorothy Havemeyer Symposium on Tendinopathy highlighted the latest understanding in the basic science and clinical challenges in tendinopathies. This includes the mechanisms leading to inflammation and tendon failure as well as to its regeneration and resolution.

Role of Analogy in Tendinopathy Research

  • Comparisons between equine and human pathology were brought up, especially the analogous pathology found in Achilles tendinopathy and intrathecal rotator cuff tears. This similarity allows for collaboration between the medical and veterinary fields.

Importance of Clinical Trials

  • The research emphasizes the lessons that can be learned from human medicine regarding the design, conduct, and impact of clinical trials. The authors urged for designing appropriate studies to answer clear questions, socializing the studies to achieve good enrollment, and considering the cost in addressing clinically significant questions.

Constraints and Possible Alternatives in Equine Medicine

  • Budget constraints often encountered in equine medicine necessitate careful consideration of alternative research methods. Observational studies and registries are suggested as cost-effective options for studying tendinopathies in horses.

Cite This Article

APA
Smith RKW, McIlwraith CW. (2021). “One Health” in tendinopathy research: Current concepts. J Orthop Res, 39(8), 1596-1602. https://doi.org/10.1002/jor.25035

Publication

Journal of orthopaedic research : official publication of the Orthopaedic Research Society
ISSN: 1554-527X
NlmUniqueID: 8404726
Country: United States
Language: English
Volume: 39
Issue: 8
Pages: 1596-1602

Researcher Affiliations

Smith, Roger K W
  • Department of Clinical Sciences and Services, The Royal Veterinary College, Hatfield, Herts, UK.
McIlwraith, C Wayne
  • Department of Clinical Sciences, Orthopaedic Research Center, C. Wayne McIlwraith Translational Medicine Institute, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.

MeSH Terms

  • Achilles Tendon / pathology
  • Animals
  • Horses
  • Humans
  • Rotator Cuff Injuries
  • Tendinopathy / diagnosis
  • Tendinopathy / pathology
  • Tendinopathy / therapy

Grant Funding

  • MR/J006815/1 / Medical Research Council

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Citations

This article has been cited 15 times.
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