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Home / Equine Research Bank / Animals (Basel) / Plasma-Ionized Magnesium in Hospitalized Horses with Gastroi...
Animals : an open access journal from MDPI2022; 12(12); 1479; doi: 10.3390/ani12121479

Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome.

Abstract: Magnesium disorders in horses with gastrointestinal disorders or systemic inflammatory response syndrome (SIRS) are scarcely characterized. The purpose of the study was to explore the association of magnesium disorders with diagnosis, SIRS and mortality in horses admitted to a referral equine hospital. In total, 75 sick horses were included in an observational prospective study and classified as: obstructive ( = 17), inflammatory ( = 10) and ischemic gastrointestinal disorders ( = 12), and other non-gastrointestinal systemic disorders ( = 36). All sick horses were also divided according to the presence ( = 26) or absence of SIRS, and survival to discharge from hospital (survivors ( = 61) and non-survivors ( = 14). In addition, 26 horses were included as controls. On admission, mean (iMg) (95% confidence interval (CI)) in the SIRS group (0.47 (0.43-0.50 mmol/L)) was within the normal range (0.4-0.6 mmol/L). The obstructive group had lower (iMg) compared to the control group (0.44 (0.38-0.51 mmol/L) vs. 0.56 (0.50-0.61 mmol/L); = 0.001). In total, 8 out of 17 (47%) horses with obstructive lesions presented with hypomagnesemia compared to controls (4% (1/26)) ( = 0.001). In conclusion, hypomagnesemia was more prevalent on admission in horses in the obstructive group, and to a lesser extent, in the inflammatory and ischemic groups. In contrast to human ICU patients, the proportion of hospitalized horses with hypomagnesemia was not associated with mortality.
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Publication Date: 2022-06-07 PubMed ID: 35739816PubMed Central: PMC9219524DOI: 10.3390/ani12121479Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates the relationship between magnesium disorders, such as hypomagnesemia (low magnesium levels), in horses suffering from gastrointestinal (GI) disorders or systemic inflammatory response syndrome (SIRS). The study discovered that horses with obstructive GI disorders have a greater prevalence of hypomagnesemia upon hospital admission. However, unlike in human-intensive care patients, low magnesium levels in hospitalized horses were not linked to mortality.

Introduction and Methodology of the Research

  • The study focuses on exploring the correlation between magnesium disorders, specifically hypomagnesemia, with diagnosis, SIRS, and mortality in hospitalized horses. This association is not very well characterized in existing veterinary literature.
  • The research is a prospective observational study involving a total of 75 sick horses. The horses are classified into four groups based on their disorders: obstructive gastrointestinal disorders, inflammatory gastrointestinal disorders, ischemic gastrointestinal disorders, and other non-gastrointestinal systemic disorders.
  • These sick horses are also separated based on the presence or absence of SIRS, a condition that occurs when the horse’s body responds to an infection or injury.
  • The study also included 26 horses as a control group for comparison.

Findings of the Research

  • Upon admission, the mean plasma-ionized magnesium (iMg) in the SIRS group of horses was found to be within the normal range.
  • The study found that horses with obstructive GI disorders had significantly lower iMg levels compared to the control group which is an indication of hypomagnesemia.
  • About 47% of the horses with obstructive lesions were diagnosed with hypomagnesemia in comparison to only 4% in the control group.

Conclusion of The Research

  • The research concluded that horses in the obstructive group are more likely to present with hypomagnesemia on hospital admission, followed by horses in the inflammatory and ischemic groups.
  • This study contradicts the observations in human ICU patients where hypomagnesemia is often associated with increased mortality. However, the same is not true in the case of hospitalized horses, suggesting varying physiological responses across species.

Cite This Article

APA
Sanmartí J, Armengou L, Troya-Portillo L, Robles-Guirado JÁ, Bassols A, Ríos J, Jose-Cunilleras E. (2022). Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome. Animals (Basel), 12(12), 1479. https://doi.org/10.3390/ani12121479

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 12
PII: 1479

Researcher Affiliations

Sanmartí, Julia
  • Servei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
  • Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Armengou, Lara
  • Servei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Troya-Portillo, Lucas
  • Servei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
  • Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Robles-Guirado, José Ángel
  • Departament de Bioquímica i Biologia Molecular, Facultat de Veterinaria, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Bassols, Anna
  • Departament de Bioquímica i Biologia Molecular, Facultat de Veterinaria, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Ríos, José
  • Department of Clinical Farmacology, Hospital Clinic, Medical Statistics Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
  • Biostatistics Unit, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
Jose-Cunilleras, Eduard
  • Servei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
  • Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.

Conflict of Interest Statement

The authors declare no conflict of interest. The authors have no affiliations or final involvement with any organization or entity with a financial interest in, or in financial competition with the subject matter discussed in this article. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Citations

This article has been cited 2 times.
  1. Zhang LC, Ye ZQ, Shuai WL, He CQ, Yu XY, Zhuang LM, Gong LM. Magnesium depletion score and stroke in US adults: Analysis of NHANES 1999 to 2018. Medicine (Baltimore) 2025 Dec 19;104(51):e46376.
    doi: 10.1097/MD.0000000000046376pubmed: 41430980google scholar: lookup
  2. Etemadi F, Tabatabaei Naeini A, Aminlari M. Assessment of calcium, phosphorus, magnesium, vitamin D and PTH levels in sera of lame horses. Vet Med Sci 2023 Sep;9(5):2070-2077.
    doi: 10.1002/vms3.1198pubmed: 37466035google scholar: lookup
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