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Home / Equine Research Bank / J Vet Intern Med / Prognostic Value and Development of a Scoring System in Hors...
Journal of veterinary internal medicine2017; 31(2); 582-592; doi: 10.1111/jvim.14670

Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome.

Abstract: Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. Objective: To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome. Methods: A total of 479 consecutive adult horse emergency admissions to a private primary referral practice. Methods: Prospective observational study. All adult horses admitted for emergency treatment over the study period were included. Multivariate logistic regression and stepwise model selection were used. Results: Each of the 4 SIRS criteria was associated with outcome in this population. Thirty-one percent of emergency cases had 2 or more abnormal SIRS criteria on admission and were defined as SIRS cases. SIRS was associated with increased odds of death (odds ratio [OR] = 8.22; 95% CI, 4.61-15.18; P < .001), an effect mainly found for acute gastrointestinal cases. SIRS cases were assigned a SIRS score of 2, 3, or 4, according to the number of abnormal SIRS criteria fulfilled on admission, and SIRS3 and SIRS4 cases had increased odds of death compared to SIRS2 cases (OR = 4.45; 95% CI, 1.78-11.15; P = .002). A model of severe SIRS including the SIRS score, blood lactate concentration, and color of the mucous membranes best predicted outcome in this population of horses. Conclusions: Systemic inflammatory response syndrome is associated with an increased risk of death in adult horses presenting with acute gastrointestinal illnesses. The model of severe SIRS proposed in this study could be used to assess the status and prognosis of adult equine emergency admissions.
Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2017-02-16 PubMed ID: 28207163PubMed Central: PMC5354005DOI: 10.1111/jvim.14670Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper had a focus on understanding the prognostic value of measures concerning systemic inflammatory response syndrome (SIRS) in horses. The researchers identified a model of severe SIRS that could be deemed accurate in predicting the outcome of an adult horse’s condition, especially in relation to acute gastrointestinal illnesses.

Investigation Methodology

  • The study was conducted on 479 adult horses as they were admitted due to emergencies in the span of a pre-determined period to a primary referral clinic. This is termed a prospective observational study.
  • The method of approach to understand the relevance of SIRS in horses comprised multivariate logistic regression and a stepwise model selection.

Findings and Conclusions

  • Every SIRS criteria was found to be associated, in some measure, with the outcome in the studied population of horses.
  • Among the overall cases, 31% had 2 or more abnormal SIRS criteria, at the time of their admission, asserting them to be SIRS cases.
  • Under this condition, the likelihood of death was higher (with an odds ratio of 8.22). This was particularly notable in horses experiencing acute gastrointestinal issues.
  • Depending upon the number of abnormal SIRS criteria at admission, the horses were assigned a SIRS score of 2, 3, or 4. Increased risk of death was noted in horses with SIRS3 and SIRS4 scores.
  • Upon evaluation, a model featuring severe SIRS, that takes into account the SIRS score, blood lactate concentration, and the color of the mucous membranes, was discovered to be efficient in predicting the outcome of the horses.
  • The researchers concluded that systemic inflammatory response syndrome is a tangible risk factor for death in horses presenting with acute gastrointestinal illnesses. They propose the model of severe SIRS, derived from this study, to evaluate the status and prognosis of adult equine emergency admissions.

Cite This Article

APA
Roy MF, Kwong GP, Lambert J, Massie S, Lockhart S. (2017). Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome. J Vet Intern Med, 31(2), 582-592. https://doi.org/10.1111/jvim.14670

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 31
Issue: 2
Pages: 582-592

Researcher Affiliations

Roy, M-F
  • Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Kwong, G P S
  • Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Lambert, J
  • Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Massie, S
  • Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Lockhart, S
  • Moore Equine Veterinary Center, North Clinic, Rocky View County, AB, Canada.

MeSH Terms

  • Animals
  • Female
  • Gastrointestinal Diseases / diagnosis
  • Gastrointestinal Diseases / mortality
  • Gastrointestinal Diseases / veterinary
  • Horse Diseases / diagnosis
  • Horse Diseases / mortality
  • Horses
  • Lactic Acid / blood
  • Male
  • Mucous Membrane / physiology
  • Prognosis
  • Prospective Studies
  • Systemic Inflammatory Response Syndrome / diagnosis
  • Systemic Inflammatory Response Syndrome / mortality
  • Systemic Inflammatory Response Syndrome / veterinary

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