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Pathogens (Basel, Switzerland)2021; 10(9); 1141; doi: 10.3390/pathogens10091141

Rhodococcus equi-Occurrence in Goats and Clinical Case Report.

Abstract: infection is commonly known in equine medicine to cause frequently fatal rhodococcosis. Infections in other species and people are also reported. Clinical manifestation in goats is relatively similar to horses and humans, but data regarding bacterium prevalence are scarce. Thus, the study aimed to estimate the occurrence of in goats. Methods: During post mortem examination, submandibular, mediastinal, and mesenteric lymph nodes were collected. Standard methods were used for bacteria isolation and identification. Results: A total of 134 goats were examined, and 272 lymph node samples were collected. was isolated from four animals. All four isolates carried the gene, and one also had and pVAPN plasmid genes. Conclusions: To the authors' best knowledge, this is the first report of occurrence and genetic diversity in goats. The results may help create a model for treating rhodococcosis in other animal species and assessing the role of meat contamination as a potential source of human infection. This research should be considered a pilot study for further application of the goat as a model of infection in horses and humans.
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Publication Date: 2021-09-04 PubMed ID: 34578172PubMed Central: PMC8472617DOI: 10.3390/pathogens10091141Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the presence of Rhodococcus equi, a bacterium that causes the lethal illness rhodococcosis, in goats. The researchers carried out autopsies on 134 goats, analyzing their lymph nodes for signs of the bacteria. Their findings not only highlight that this bacterium can infect goats, but also provide useful insights for potentially treating rhodococcosis in other animals as well as humans.

Research Methodology

  • The study was aimed at estimating the occurrence of Rhodococcus equi in goats as the data relating to its prevalence in goats were sparse.
  • As part of the research, 134 goats were examined post-mortem, and their submandibular, mediastinal, and mesenteric lymph nodes were collected.
  • Standard methods were used for bacteria isolation and identification using these lymph node samples.

Research Findings

  • A total of 272 lymph node samples were collected from these 134 goats.
  • Rhodococcus equi was isolated from four of these animals, indicating its presence in goats.
  • All the isolated strains of the bacteria showed the presence of the vapA gene. In addition, one of them also had the traA and pVAPN plasmid genes.

Conclusions and Future Applications

  • As per the authors’ knowledge, this research shows the first evidence of Rhodococcus equi occurrence and its genetic diversity in goats.
  • These findings may be pivotal in formulating a model for treating rhodococcosis in other animal species.
  • Further, it helps in assessing the meat contamination role as a potential source of Rhodococcus equi infection in humans, thereby finding potential solutions for such public health concern.
  • The authors suggest considering the research as a baseline study for future application of the goat as a model of Rhodococcus equi infection in horses and humans.

Cite This Article

APA
Żychska M, Witkowski L, Klementowska A, Rzewuska M, Kwiecień E, Stefańska I, Czopowicz M, Szaluś-Jordanow O, Mickiewicz M, Moroz A, Bonecka J, Kaba J. (2021). Rhodococcus equi-Occurrence in Goats and Clinical Case Report. Pathogens, 10(9), 1141. https://doi.org/10.3390/pathogens10091141

Publication

Pathogens (Basel, Switzerland)
ISSN: 2076-0817
NlmUniqueID: 101596317
Country: Switzerland
Language: English
Volume: 10
Issue: 9
PII: 1141

Researcher Affiliations

Żychska, Monika
  • Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776 Warsaw, Poland.
Witkowski, Lucjan
  • Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776 Warsaw, Poland.
Klementowska, Agnieszka
  • Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776 Warsaw, Poland.
Rzewuska, Magdalena
  • Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-786 Warsaw, Poland.
Kwiecień, Ewelina
  • Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-786 Warsaw, Poland.
Stefańska, Ilona
  • Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-786 Warsaw, Poland.
Czopowicz, Michał
  • Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776 Warsaw, Poland.
Szaluś-Jordanow, Olga
  • Department of Small Animal Diseases with Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776 Warsaw, Poland.
Mickiewicz, Marcin
  • Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776 Warsaw, Poland.
Moroz, Agata
  • Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776 Warsaw, Poland.
Bonecka, Joanna
  • Department of Small Animal Diseases with Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776 Warsaw, Poland.
Kaba, Jarosław
  • Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776 Warsaw, Poland.

Grant Funding

  • 9506/E-385/R/2018 / Ministry of Science and Higher Education of the Republic of Poland

Conflict of Interest Statement

The authors declare no conflict of interest.

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