Chest1978; 73(2 Suppl); 253-256; doi: 10.1378/chest.73.2_supplement.253

Role of intracranial [H+] receptor in physiologic regulation of ventilation in ponies.

Forster, HV
·
Bisgard, GE
·
Dempsey, JA
·
Orr, JA

Abstract: Numerous studies have demonstrated the existence of an intracranial [H+] chemoreceptor mechanism capable of stimulating ventilation. 1 Supposedly, this chemoreceptor is located 0.2 mm below the surface of the ventrolateral side of the medulla and is responsive to [H+] in the surrounding cerebral extracellular fluid (ECF). During chronic conditions, ECF [H+] is supposedly in equilibrium with CSF [H+]; hence, stimulus level can be established through sampling and analysis of CSF. In this presentation, we summarize data from studies on spontaneously breathing, unanesthetized ponies which suggests this [H+] receptor may not contribute significantly to physiologic regulation of ventilation. We also provide evidence in support of one postulated CNS mechanism modulating ventilatory responsiveness.

Get Full Text

Publication Date: 1978-02-01 PubMed ID: 23256DOI: 10.1378/chest.73.2_supplement.253Google Scholar: Lookup

The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.

Facebook X LinkedIn Email Copy

Summary
Cite This
Publication
Affiliations
MeSH
Citations

Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

“

This research study investigates the role of an intracranial receptor sensitive to [H+] (hydrogen ions) in regulating breathing in ponies. The researchers found that this [H+] receptor might not significantly contribute to the physiological regulation of respiration. They also present evidence supporting one possible central nervous system mechanism modulating breathing responsiveness.

Role of Intracranial [H+] receptor

The study acknowledges the existence of an intracranial receptor or chemoreceptor that responds to hydrogen ions ([H+]) levels and stimulates ventilation (breathing).
According to past studies, this receptor is part of the medulla, a part of the brain and specifically located on the ventrolateral side, slightly below the surface.
The receptor’s activity is influenced by the concentration of [H+] in the surrounding cerebrospinal fluid (CSF) – the fluid within which the brain and spine are suspended.

[H+] Equilibrium Condition

Under chronic conditions, an equilibrium is believed to exist between the [H+] concentration in the local cerebral extracellular fluid (ECF) and the cerebrospinal fluid (CSF).
This equilibrium effectively means that by sampling and analyzing the CSF, one could establish the level of stimulus for ventilation.

Physiological Regulation of Ventilation

The focus of the research is to evaluate the [H+] receptor’s contribution towards the physiological regulation of ventilation.
The data gathered from unanesthetized, ‘naturally breathing’ ponies suggested that this [H+] receptor might not be a major contributor to the physiological regulation of breathing.

CNS Mechanism Modulating Ventilation

Beyond the role of the [H+] receptor, the research also investigated a potential central nervous system (CNS) mechanism that controls the responsiveness of the breathing process.
The team presented evidence supporting the existence of such a CNS mechanism, implying that there are additional factors at play in regulating and adjusting the breathing dynamics depending on the need of the ponies’ bodies.

“

Cite This Article

APA

Forster HV, Bisgard GE, Dempsey JA, Orr JA. (1978). Role of intracranial [H+] receptor in physiologic regulation of ventilation in ponies. Chest, 73(2 Suppl), 253-256. https://doi.org/10.1378/chest.73.2_supplement.253