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Journal of medical ethics1996; 22(4); 199-203; doi: 10.1136/jme.22.4.199

Should a doctor prescribe hormone replacement therapy which has been manufactured from mare’s urine?

Abstract: Many clinicians are experiencing consumer resistance to the prescription of equine HRT (that is hormone replacement therapy which has been manufactured from mare's urine). In this paper I consider the ethical implications of prescribing these preparations. I decide that patients should have a right to refuse such treatment but also ask whether a prescribing doctor should choose one preparation over another on moral grounds. I determine that there is prima facie evidence to suggest that mares may suffer and that prescription of equine HRT (instead of synthetic oestrogen-oestriol) would therefore have to be justified in terms of either offering greater benefits to the women or offering greater value for money to the health service. I find that there is no substantial evidence to suggest that equine HRT offers unique advantages over and above oestriol. I conclude that it would be preferable for a doctor to recommend the synthetic oestrogen to women who want relief from the symptoms of the menopause and protection from osteoporosis and cardiovascular disease.
Publication Date: 1996-08-01 PubMed ID: 8863143PubMed Central: PMC1376997DOI: 10.1136/jme.22.4.199Google Scholar: Lookup
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  • Comparative Study
  • Journal Article

Summary

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This research investigates the ethical implications of prescribing hormone replacement therapy (HRT) derived from mare’s urine. The paper concludes that it’s preferable for doctors to recommend synthetic estrogen to women, given it provides similar benefits to the menopause symptoms and health protection as HRT produced from mare’s urine, presumably causing less harm to mares.

Ethical Considerations

  • The paper raises ethical questions on the utilization of hormone replacement therapies made from the urine of mares. It proposes that, while patients have the right to refuse treatments founded on their moral quandaries or beliefs, doctors also need to consider their ethical responsibility when recommending certain medications over others.

Assessment of Alternatives

  • With the premise that mares potentially suffer during the manufacture of equine HRT, the author argues that its prescription must be justified by either greater health benefits to the woman or better cost-efficiency for the health service, compared to synthetic variants like oestriol.

Evidence Exploration

  • Reviewing the existing evidence, the research finds no substantial proof that equine HRT provides distinct advantages over synthetic oestrogen-oestriol. This means that there’s no clear-cut health or cost justification for prescribing equine-derived HRT over synthetic alternatives.

Conclusion

  • Given the potential ethical concerns on mare welfare and the lack of proven superior health or cost benefits, the paper ultimately concludes that doctors should primarily recommend synthetic oestrogen to women seeking relief from menopausal symptoms and protection against osteoporosis or cardiovascular disease.

Cite This Article

APA
Cox D. (1996). Should a doctor prescribe hormone replacement therapy which has been manufactured from mare’s urine? J Med Ethics, 22(4), 199-203. https://doi.org/10.1136/jme.22.4.199

Publication

ISSN: 0306-6800
NlmUniqueID: 7513619
Country: England
Language: English
Volume: 22
Issue: 4
Pages: 199-203

Researcher Affiliations

Cox, D
  • Cambridge University Clinical School.

MeSH Terms

  • Animal Rights
  • Animals
  • Bone Density / drug effects
  • Cardiovascular Diseases / prevention & control
  • Cost Control
  • Disclosure
  • Estriol / economics
  • Estriol / pharmacology
  • Estrogen Replacement Therapy / economics
  • Estrogens, Conjugated (USP) / economics
  • Estrogens, Conjugated (USP) / pharmacology
  • Ethical Theory
  • Ethics, Medical
  • Female
  • Horses
  • Humans
  • Menopause / drug effects
  • Moral Obligations
  • Morals
  • Personal Autonomy
  • Risk Assessment
  • Stress, Psychological
  • Urine / chemistry

References

This article includes 2 references
  1. Holland EF, Leather AT, Studd JW, Garnett TJ. The effect of a new sequential oestradiol valerate and levonorgestrel preparation on the bone mineral density of postmenopausal women.. Br J Obstet Gynaecol 1993 Oct;100(10):966-7.
  2. Nabulsi AA, Folsom AR, White A, Patsch W, Heiss G, Wu KK, Szklo M. Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. The Atherosclerosis Risk in Communities Study Investigators.. N Engl J Med 1993 Apr 15;328(15):1069-75.
    pubmed: 8384316doi: 10.1056/NEJM199304153281501google scholar: lookup

Citations

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