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Home / Equine Research Bank / Emerg Infect Dis / Shrews as reservoir hosts of borna disease virus.
Emerging infectious diseases2006; 12(4); 675-677; doi: 10.3201/eid1204.051418

Shrews as reservoir hosts of borna disease virus.

Abstract: Borna disease virus (BDV) is the causative agent of severe T-cell-mediated meningoencephalitis in horses, sheep, and other animal species in central Europe. Here we report the first unequivocal detection of a BDV reservoir species, the bicolored white-toothed shrew, Crocidura leucodon, in an area in Switzerland with endemic Borna disease.
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Publication Date: 2006-05-18 PubMed ID: 16704819PubMed Central: PMC3294707DOI: 10.3201/eid1204.051418Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research identifies the bicolored white-toothed shrew as the first confirmed reservoir species for Borna disease virus (BDV), a pathogen known to cause severe meningoencephalitis in various animal species in Europe.

Introduction to the study

  • The research was necessitated by the need to identify the reservoir species for the Borna disease virus, which until now, was not conclusively determined. BDV is a lethal pathogen, causing severe T-cell-mediated meningoencephalitis – an inflammation of the brain and the membranes that surround it in horses, sheep, and other animals particularly in Central Europe.

Findings of the study

  • The investigators have made the first conclusive detection of the BDV reservoir species, the bicolored white-toothed shrew (Crocidura leucodon), in an area in Switzerland where Borna disease is endemic.
  • Reservoir species are significant in pathogen research as they can harbor diseases without suffering from the disease’s harmful effects. Identifying them provides valuable insights into disease dynamics and aids in the prevention and control of disease outbreaks.

Implications of the research

  • The identification of the bicolored white-toothed shrew as the BDV reservoir species will facilitate further studies surrounding the pathology, spread, and possible control measures for BDV.
  • This would be of great significance, especially in areas where BDV is endemic and might enhance the development of effective strategies in managing and curtailing the spread of BDV.

Conclusion

  • The identification of a BDV reservoir species marks a significant milestone in understanding the disease’s transmission dynamics and planning for effective control measures. Future research may focus on understanding the BDV’s interaction with the shrew and other species susceptibility to the disease.

Cite This Article

APA
Hilbe M, Herrsche R, Kolodziejek J, Nowotny N, Zlinszky K, Ehrensperger F. (2006). Shrews as reservoir hosts of borna disease virus. Emerg Infect Dis, 12(4), 675-677. https://doi.org/10.3201/eid1204.051418

Publication

Emerging infectious diseases
ISSN: 1080-6040
NlmUniqueID: 9508155
Country: United States
Language: English
Volume: 12
Issue: 4
Pages: 675-677

Researcher Affiliations

Hilbe, Monika
  • University of Zurich, Zurich, Switzerland. hilbe@vetpath.unizh.ch
Herrsche, Romana
    Kolodziejek, Jolanta
      Nowotny, Norbert
        Zlinszky, Kati
          Ehrensperger, Felix

            MeSH Terms

            • Animals
            • Borna Disease / epidemiology
            • Borna Disease / virology
            • Borna disease virus / isolation & purification
            • Brain / virology
            • Disease Reservoirs / veterinary
            • Disease Reservoirs / virology
            • Heart / virology
            • Mice
            • Moles / virology
            • Shrews / virology
            • Switzerland

            References

            This article includes 14 references

            Citations

            This article has been cited 44 times.
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