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International journal for parasitology. Drugs and drug resistance2021; 17; 36-45; doi: 10.1016/j.ijpddr.2021.07.003

Spread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses – Yet it is of major concern.

Abstract: Anthelmintic resistance (AR) has thus far only rarely been reported for intestinal helminths of dogs and cats, in contrast to parasites of livestock and horses. We highlight possible reasons for this striking and important discrepancy, including ecological, biological and genetic factors and/or intervention regimens of key intestinal helminths concerning both host groups. In view of the current knowledge related to the genetics, mechanisms and principles of AR development, we point at issues which in our view contribute to a comparatively lower risk of AR development in intestinal helminths of dogs and cats. Finally, we specify research needs and provide recommendations by which, based on the available information about AR in ruminant and equine helminths, the development of AR in dog and cat helminths may best be documented, prevented or at least postponed.
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Publication Date: 2021-07-25 PubMed ID: 34343829PubMed Central: PMC8347694DOI: 10.1016/j.ijpddr.2021.07.003Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study looks into the relatively less-seen occurrence of anthelmintic resistance (AR) in intestinal helminths of dogs and cats, compared to those found in livestock and horses. The research uncovers possible reasons for this variance and suggests measures to document, prevent or delay the development of AR in dogs and cats.

Understanding the Disparity in Anthelmintic Resistance (AR)

  • The study initially observes a noticeable difference in the occurrence of AR in intestinal helminths of dogs and cats as opposed to those in livestock and horses. This difference calls for an in-depth investigation to understand factors contributing to this discrepancy.
  • The research suggests that various ecological, biological, genetic factors, and/or intervention regimens might be responsible for this variation. For example, the environment that these animals reside in, their genetic makeup, or the way deworming practices are conducted could impact the development of AR.

Potential Factors Lowering Risk of AR in Dogs and Cats

  • The paper outlines potential issues that may have resulted in a comparatively lower risk of AR development in intestinal helminths of dogs and cats. It’s suggested that certain characteristics or practices specific to dogs and cats might have prevented the rapid development of resistance seen in livestock and horses.
  • These specifics might include inherent genetic traits, differences in their biological systems, or perhaps even particular dog and cat dewormer application schedules.

Actionable Measures to Manage AR in Dogs and Cats

  • The paper concludes by laying out research needs and recommendations to manage the development of AR in dog and cat helminths. It suggests using the information about AR in ruminants and equine helminths to guide the approach for dogs and cats.
  • The overarching goal is to ensure that measures are in place to document the incidence of AR in dogs and cats, as well as strategies to prevent, or at the very least, delay, the development of AR. This could involve adjusting deworming schedules, using different types of dewormers, conducting more high-level research into the genetic makeup of these helminths, amongst other measures.

Cite This Article

APA
von Samson-Himmelstjerna G, Thompson RA, Krücken J, Grant W, Bowman DD, Schnyder M, Deplazes P. (2021). Spread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses – Yet it is of major concern. Int J Parasitol Drugs Drug Resist, 17, 36-45. https://doi.org/10.1016/j.ijpddr.2021.07.003

Publication

International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
NlmUniqueID: 101576715
Country: Netherlands
Language: English
Volume: 17
Pages: 36-45

Researcher Affiliations

von Samson-Himmelstjerna, Georg
  • Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Germany. Electronic address: gvsamson@fu-berlin.de.
Thompson, Rc Andrew
  • School of Veterinary and Health Sciences, Murdoch University, Australia.
Krücken, Jürgen
  • Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Germany.
Grant, Warwick
  • Department of Physiology, Anatomy & Microbiology, La Trobe University, Australia.
Bowman, Dwight D
  • Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, USA.
Schnyder, Manuela
  • Institute of Parasitology, University of Zurich, Switzerland.
Deplazes, Peter
  • Institute of Parasitology, University of Zurich, Switzerland.

MeSH Terms

  • Animals
  • Anthelmintics / pharmacology
  • Anthelmintics / therapeutic use
  • Cat Diseases / drug therapy
  • Cats
  • Dog Diseases / drug therapy
  • Dog Diseases / prevention & control
  • Dogs
  • Drug Resistance / genetics
  • Helminths / genetics
  • Horses
  • Ruminants

Conflict of Interest Statement

Manuela Schnyder, Peter Deplazes, Dwight Bowman and Georg von Samson-Himmelstjerna each declare that they repeatedly have acted as consultant for veterinary pharmaceutical and diagnostic companies and have previous and ongoing research collaborations with various veterinary pharmaceutical companies. Jürgen Krücken declares that he has previous and ongoing research collaborations with various veterinary pharmaceutical companies. Andrew Thompson declares that he has previous research collaborations with various veterinary pharmaceutical companies. Warwick Grant declares no conflict of interest.

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