The effect of equine recombinant growth hormone on second intention wound healing in horses.
Abstract: To evaluate the effect of intramuscular administration of recombinant equine growth hormone on healing of full thickness skin wounds on equine limbs. Methods: Experimental. Methods: Nine Standardbred horses. Methods: In study 1, standardized full thickness skin wounds (2.5 x 2.5 cm) were made over the dorsomedial aspect of the mid-cannon bone of 1 forelimb and 1 hindlimb in 9 horses. Wounds were bandaged without treatment (control subjects) and videorecorded twice weekly until healed. Then, in study 2, similar wounds were created on the opposite limbs; 6 horses were administered intramuscular recombinant equine growth hormone (10 microg/kg daily for 7 days, then 20 microg/kg daily for 49 days), and 3 horses (control subjects) were administered equivalent volumes of sterile water. Wounds were videorecorded twice weekly until healed. Wound healing variables were measured from the videorecordings using a computer software package and analyzed as a randomized complete block design factorial analysis of variance; significance was set at P <.05. Results: No differences in the measured variables were detected between wounds in study 1 and the control wounds in study 2. In recombinant equine growth hormone-treated horses, wounds retracted more during treatment and contracted faster after treatment stopped when compared with wounds from untreated horses. No other treatment effects were detected. Conclusions: Recombinant equine growth hormone seemingly increases wound retraction. After treatment ceases, wound contraction increases. Conclusions: Intramuscular administration of recombinant equine growth hormone (10 microg/kg daily for 7 days, then 20 microg/kg daily for 49 days) does not appear to have any beneficial clinical effect on healing of equine limb wounds.
Copyright 2002 by The American College of Veterinary Surgeons
Publication Date: 2002-07-03 PubMed ID: 12094344DOI: 10.1053/jvet.2002.33589Google Scholar: Lookup
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- Journal Article
Summary
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The study investigates the impact of a hormone treatment on the healing process of skin wounds in horses, ultimately concluding that the treatment does not appear to significantly enhance the healing process.
Research Goals and Methodology
- The purpose of the research was to examine the influence of internal administration of the recombinant equine growth hormone on the healing of thorough skin wounds on horse limbs.
- The study used an experimental setup involving nine Standardbred horses.
- Two studies were conducted. In the first one, standardized skin wounds were created on the horses without any treatment for monitoring their natural healing process.
- In the second study, similar wounds were created on the opposite limbs of the horses. Six of them were administered the recombinant equine growth hormone, while the rest of the three horses were given sterile water, serving as control subjects.
- The wounds were monitored and the healing process was videotaped twice a week until the wounds completely healed.
- Through computer software, wound healing variables from the video recordings were measured. A randomized complete block design factorial analysis of variance statistical technique was utilized for data analysis.
Findings and Conclusions
- The results showed no significant differences in the healing variables between the untreated wounds in the first study and the wounds of the control subjects in the second study.
- For horses treated with recombinant equine growth hormone, their wounds were observed to retract more during the treatment phase and contract faster after the treatment ended, as compared to wounds in untreated horses.
- No other impacts of the treatment were identified in the study.
- Finally, the research concluded that administering recombinant equine growth hormone (10 microg/kg daily for a week, then 20 microg/kg daily for seven weeks) does not appear to have any significantly beneficial effects on equine limb wound healing.
Cite This Article
APA
Dart AJ, Cries L, Jeffcott LB, Hodgson DR, Rose RJ.
(2002).
The effect of equine recombinant growth hormone on second intention wound healing in horses.
Vet Surg, 31(4), 314-319.
https://doi.org/10.1053/jvet.2002.33589 Publication
Researcher Affiliations
- University Veterinary Centre, Department of Veterinary Clinical Sciences, University of Sydney, Camden, Australia.
MeSH Terms
- Animals
- Bandages / veterinary
- Forelimb / injuries
- Growth Hormone / administration & dosage
- Growth Hormone / pharmacology
- Hindlimb / injuries
- Horses / injuries
- Injections, Intramuscular / veterinary
- Random Allocation
- Skin / injuries
- Treatment Outcome
- Video Recording
- Wound Healing / drug effects
- Wounds and Injuries / drug therapy
- Wounds and Injuries / veterinary
Citations
This article has been cited 5 times.- Ribeiro G, Carvalho L, Borges J, Prazeres J. The Best Protocol to Treat Equine Skin Wounds by Second Intention Healing: A Scoping Review of the Literature. Animals (Basel) 2024 May 18;14(10).
- Helal IE, Al-Abbadi HA, El-Daharawy MH, Ahmed MF. Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses. J Anim Sci Technol 2022 Sep;64(5):997-1007.
- Lawless SP, Cohen ND, Lawhon SD, Chamoun-Emanuelli AM, Wu J, Rivera-Vélez A, Weeks BR, Whitfield-Cargile CM. Effect of gallium maltolate on a model of chronic, infected equine distal limb wounds. PLoS One 2020;15(6):e0235006.
- Alkhilaiwi F, Wang L, Zhou D, Raudsepp T, Ghosh S, Paul S, Palechor-Ceron N, Brandt S, Luff J, Liu X, Schlegel R, Yuan H. Long-term expansion of primary equine keratinocytes that maintain the ability to differentiate into stratified epidermis. Stem Cell Res Ther 2018 Jul 4;9(1):181.
- Engelen M, Besche B, Lefay MP, Hare J, Vlaminck K. Effects of ketanserin on hypergranulation tissue formation, infection, and healing of equine lower limb wounds. Can Vet J 2004 Feb;45(2):144-9.
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