The Canadian veterinary journal = La revue veterinaire canadienne2004; 45(2); 144-149;

Effects of ketanserin on hypergranulation tissue formation, infection, and healing of equine lower limb wounds.

Engelen, M
·
Besche, B
·
Lefay, MP
·
Hare, J
·
Vlaminck, K

Abstract: The objective of this multicentre, randomized, controlled field study was to determine the efficacy of ketanserin gel in preventing exuberant granulation tissue formation (hypergranulation) and infection in equine lower limb wounds. Horses and ponies (n = 481) with naturally occurring wounds were randomized to either topical treatment with ketanserin gel (n = 242) or a positive control (Belgium, Germany: ethacridin lactate solution, n = 120; France, United Kingdom: malic, benzoic, and salicylic acid [MBS] cream, n = 119). Treatment continued until the wound healed (success), formed hypergranulation tissue (failure), or became infected (failure). Treatment was terminated after 6 months in all remaining animals. Ketanserin was successful in 88% of cases. Wounds treated with ketanserin were 2 and 5 times more likely to heal successfully than were those treated with MBS or ethacridin lactate, respectively. Ketanserin gel is thus more effective than these standard treatments in preventing hypergranulation tissue and infection of equine lower limb wounds. Résumé — Les effets d’un gel de kétanserin sur la guérison de plaies situées à l’aspect distal du membre équin. L’objectif de cette étude de terrain multicentrique, était de déterminer l’efficacité d’un gel de kétanserin dans la prévention de l’hypergranulation et l’infection de plaies appendiculaires équines. Des chevaux et des poneys (n = 481) ayant des plaies traumatiques furent placés de façon aléatoire dans deux groupes. Les animaux du premier groupe reçurent un traitement topique de gel de kétanserin (n = 242) alors que ceux du deuxième groupe reçurent un contrôle positif (Belgique, Allemagne : solution lactate d’éthacridine, n = 120; France, Royaume Uni : onguent d’acides malique, benzoïque et salicylique [MBS], n = 119). Le traitement fut poursuivi jusqu’à guérison (succès), hypergranulation (échec), ou infection (échec) de la plaie. Le gel de kétanserin fut un succès dans 88 % des cas. Les plaies soignées avec ce traitement topique furent 2 et 5 fois plus aptes à guérir de façon convenable que celles recevant le MBS ou le lactate d’éthacridine. Il est donc apparent que le gel de kétanserin est un traitement efficace pour la prévention d’hypergranulation et d’infection de plaies à l’aspect distal du membre équin. (Traduit par Docteure Christine Théorêt)

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Publication Date: 2004-03-18 PubMed ID: 15025151PubMed Central: PMC548604

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Summary
Cite This
Publication
Affiliations
MeSH
References
Citations

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support
Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper presents an equine study that analyzes the effectiveness of ketanserin gel in the prevention of excessive granulation tissue formation, commonly known as hypergranulation, and infection in lower limb wounds in horses. The study determined that ketanserin gel is more effective than the standard treatments.

Research Method

The researchers conducted a randomized-controlled study across multiple locations to gauge the efficiency of ketanserin gel in preventing hypergranulation and infection in equine lower limb wounds.
A total of 481 horses and ponies with naturally occurring wounds were used in this study. The animals were randomly assigned to receive either ketanserin gel (242 in number) or a positive control treatment (239 in number). The positive control treatment varied according to the country in which it was administered: ethacridin lactate solution in Belgium and Germany (120 horses), and malic, benzoic, and salicylic acid (MBS) cream in France and the United Kingdom (119 horses).
Treatment was continued until the wound healed successfully (designated as success), formed hypergranulation tissue (designated as failure), or became infected (also designated as failure). Treatment was concluded after 6 months for all remaining animals in the study that had not met any of these conditions.

Results

Ketanserin gel treatment was found to be successful in 88% of the cases involved in this study.
The study also showed that wounds treated with ketanserin were 2 and 5 times more likely to heal successfully than those treated with MBS cream or ethacridin lactate solution, respectively.

Conclusions

Based on the results, the researchers concluded that ketanserin gel is more effective than the standard treatments (MBS cream or ethacridin lactate solution) in preventing the formation of hypergranulation tissue and infection in equine lower limb wounds.

Cite This Article

APA

Engelen M, Besche B, Lefay MP, Hare J, Vlaminck K. (2004). Effects of ketanserin on hypergranulation tissue formation, infection, and healing of equine lower limb wounds. Can Vet J, 45(2), 144-149.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne

ISSN: 0008-5286

NlmUniqueID: 0004653

Country: Canada

Language: English

Volume: 45

Issue: 2

Pages: 144-149

Researcher Affiliations

Engelen, Marc

Janssen Animal Health BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium. mengelen@janbe.jnj.com

Besche, Béatrice

Lefay, Marie-Paul

Hare, Jonathan

Vlaminck, Kathleen

MeSH Terms

Administration, Topical
Animals
Female
Gels
Granulation Tissue / drug effects
Granulation Tissue / pathology
Horse Diseases / drug therapy
Horses / injuries
Infection Control
Ketanserin / administration & dosage
Ketanserin / pharmacology
Male
Platelet Aggregation Inhibitors / administration & dosage
Platelet Aggregation Inhibitors / pharmacology
Treatment Outcome
Wound Healing / drug effects
Wounds and Injuries / drug therapy
Wounds and Injuries / veterinary

References

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