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The Equine Sarcoid: Why Are There so Many Treatment Options?
Abstract: This article discusses the main treatments for sarcoid and the specific difficulties of these. It explains to some extent why the frustrations of a condition for which there is no single treatment option have led to the burgeoning of an industry of irrational treatments. The factors that need to be considered before selecting an option for treatment are wider than is the case in most other disease entities as a result of the complexity of the condition, its variable phenotypes, and the individual perceptions and experiences of both veterinarians and owners.
Copyright © 2019 Elsevier Inc. All rights reserved.
Publication Date: 2019-05-13 PubMed ID: 31097356DOI: 10.1016/j.cveq.2019.03.006Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article explores the various treatment options for equine sarcoid, a skin disease prevalent among horses, and outlines the complications regarding its management due to its complex nature and varying phenotypic presentations.
About Equine Sarcoid
Equine sarcoid is a skin condition typically occurring in horses.
- It is a complex disease to control and manage due to its varying phenotypic expressions and differences among affected horses.
- This complexity contributes to the many treatment options available, each varying in effectiveness depending on individual horse conditions.
Diverse Treatment Options
The article talks about the many treatments available for managing equine sarcoid, and the challenges and frustrations that have led to a surge in irrational treatments.
- All treatments have their peculiarities, and their effectiveness varies from one horse to another.
- There is no single treatment option that works effectively for all manifestations of the disease.
- This has led to an increase in unverified, and sometimes irrational, treatment approaches, exacerbating the problem further.
Factors to Consider in Treatment Selection
The article highlights that it is crucial to consider several factors before selecting a treatment approach due to the complexity of the condition.
- Unlike many other diseases, the considerations for sarcoid treatment selection are not straightforward.
- Individual perceptions and experiences of veterinarians and owners significantly influence treatment choice.
- These factors might include the specific phenotype of the disease, the general health condition of the horse, and other subjective factors like cost or accessibility of treatment.
The article thus underscores the need for a more systematic approach to treating equine sarcoid. It highlights the urgency of addressing the issue of irrational treatments, and emphasizes the importance of considering a range of factors in treatment selection to enhance the chances of success and improve the horse’s quality of life.
Cite This Article
APA
Knottenbelt DC.
(2019).
The Equine Sarcoid: Why Are There so Many Treatment Options?
Vet Clin North Am Equine Pract, 35(2), 243-262.
https://doi.org/10.1016/j.cveq.2019.03.006 Publication
Researcher Affiliations
- Equine Medical Solutions Ltd, STEP Building, Kildean Business & Enterprise Hub, 146 Drip Road, Stirling, Scotland, FK8 1RW, UK. Electronic address: knotty@liverpool.ac.uk.
MeSH Terms
- Animals
- Horse Diseases / therapy
- Horses
- Sarcoidosis / therapy
- Sarcoidosis / veterinary
- Skin Neoplasms / therapy
- Skin Neoplasms / veterinary
Citations
This article has been cited 18 times.- Jindra C, Hainisch EK, Brandt S. Immunotherapy of Equine Sarcoids-From Early Approaches to Innovative Vaccines. Vaccines (Basel) 2023 Mar 30;11(4).
- Hainisch EK, Jindra C, Kirnbauer R, Brandt S. Papillomavirus-like Particles in Equine Medicine. Viruses 2023 Jan 25;15(2).
- Hainisch EK, Jindra C, Reicher P, Miglinci L, Brodesser DM, Brandt S. Bovine Papillomavirus Type 1 or 2 Virion-Infected Primary Fibroblasts Constitute a Near-Natural Equine Sarcoid Model. Viruses 2022 Nov 28;14(12).
- Pawlina-Tyszko K, Semik-Gurgul E, Ząbek T, Witkowski M. Methylation Status of Gene Bodies of Selected microRNA Genes Associated with Neoplastic Transformation in Equine Sarcoids. Cells 2022 Jun 14;11(12).
- Podstawski P, Samiec M, Skrzyszowska M, Szmatoła T, Semik-Gurgul E, Ropka-Molik K. The Induced Expression of BPV E4 Gene in Equine Adult Dermal Fibroblast Cells as a Potential Model of Skin Sarcoid-like Neoplasia. Int J Mol Sci 2022 Feb 10;23(4).
- Jindra C, Hainisch EK, Rümmele A, Wolschek M, Muster T, Brandt S. Influenza virus vector iNS1 expressing bovine papillomavirus 1 (BPV1) antigens efficiently induces tumour regression in equine sarcoid patients. PLoS One 2021;16(11):e0260155.
- Jindra C, Kamjunke AK, Jones S, Brandt S. Screening for bovine papillomavirus type 13 (BPV13) in a European population of sarcoid-bearing equids. Equine Vet J 2021 Aug 30;54(4):662-9.
- Weber LA, Funtan A, Paschke R, Delarocque J, Kalbitz J, Meißner J, Feige K, Kietzmann M, Cavalleri JV. In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate as a topical treatment for equine skin cancer. PLoS One 2020;15(11):e0241448.
- De Ridder T, Ruppin M, Wheeless M, Williams S, Reddell P. Use of the Intratumoural Anticancer Drug Tigilanol Tiglate in Two Horses. Front Vet Sci 2020;7:639.
- Frandsen SK, Gehl J, Tramm T, Thoefner MS. Calcium Electroporation of Equine Sarcoids. Animals (Basel) 2020 Mar 19;10(3).
- Melinyshyn H. Multiple excisions of an equine sarcoid and the repercussions. Can Vet J 2019 Oct;60(10):1115-1117.
- Monteiro MM, de Castro ELA, Pereira AJM, Thiesen R, Thiesen RMC, Salvarani FM. BCG Immunotherapy in Equine Sarcoid Treatment: Mechanisms, Clinical Efficacy, and Challenges in Veterinary Oncology. Viruses 2025 Sep 29;17(10).
- Cutarelli A, Buonavoglia A, Fusco G, Pellicanò R, Napoletano M, Brandt S, Roperto S. Accurate identification of bovine deltapapillomavirus in equine sarcoids by ddPCR. Sci Rep 2025 Aug 11;15(1):29414.
- De Falco F, Cutarelli A, Pellicanò R, Brandt S, Roperto S. Molecular Detection and Quantification of Ovine Papillomavirus DNA in Equine Sarcoid. Transbound Emerg Dis 2024;2024:6453158.
- Labens R, Saba C, Williams J, Hollis A, Ensink J, Jose-Cunilleras E, Jordana-Garcia M, Bergvall K, Ruppin M, Condon F, Spelta C, Elce Y, De Ridder T, Morton J, McGee C, Reddell P. Intratumoural tigilanol tiglate in the multicentre treatment of equine sarcoids and cutaneous melanomas. Equine Vet J 2026 Jan;58(1):89-104.
- Lessiak U, Melchert M, Walter I, Kummer S, Nell B, Tschulenk W, Pratscher B. Isolation-protocol, characterization, and in-vitro performance of equine umbilical vein endothelial cells. Front Vet Sci 2024;11:1421946.
- Karalus W, Subharat S, Orbell G, Vaatstra B, Munday JS. Equine sarcoids: A clinicopathologic study of 49 cases, with mitotic count and clinical type predictive of recurrence. Vet Pathol 2024 May;61(3):357-365.
- Monod A, Koch C, Jindra C, Haspeslagh M, Howald D, Wenker C, Gerber V, Rottenberg S, Hahn K. CRISPR/Cas9-Mediated Targeting of BPV-1-Transformed Primary Equine Sarcoid Fibroblasts. Viruses 2023 Sep 17;15(9).
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