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Home / Equine Research Bank / Chromosome Res / The horse genome derby: racing from map to whole genome sequ...
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2008; 16(1); 109-127; doi: 10.1007/s10577-008-1204-z

The horse genome derby: racing from map to whole genome sequence.

Abstract: The map of the horse genome has undergone unprecedented expansion during the past six years. Beginning from a modest collection of approximately 300 mapped markers scattered on the 31 pairs of autosomes and the X chromosome in 2001, today the horse genome is among the best-mapped in domestic animals. Presently, high-resolution linearly ordered gene maps are available for all autosomes as well as the X and the Y chromosome. The approximately 4350 mapped markers distributed over the approximately 2.68 Gbp long equine genome provide on average 1 marker every 620 kb. Among the most remarkable developments in equine genome analysis is the availability of the assembled sequence (EquCab2) of the female horse genome and the generation approximately 1.5 million single nucleotide polymorphisms (SNPs) from diverse breeds. This has triggered the creation of new tools and resources like the 60K SNP-chip and whole genome expression microarrays that hold promise to study the equine genome and transcriptome in ways not previously envisaged. As a result of these developments it is anticipated that, during coming years, the genetics underlying important monogenic traits will be analyzed with improved accuracy and speed. Of larger interest will be the prospects of dissecting the genetic component of various complex/multigenic traits that are of vital significance for equine health and welfare. The number of investigations recently initiated to study a multitude of such traits hold promise for improved diagnostics, prevention and therapeutic approaches for horses.
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Publication Date: 2008-02-16 PubMed ID: 18274866DOI: 10.1007/s10577-008-1204-zGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article primarily documents significant advancements in the mapping of the horse genome over the past six years. These developments have led to the potential for improved accuracy in analyzing genetic components of both monogenic and complex traits significant to equine health and welfare.

Expansion of the Horse Genome Map

  • The article explores the notable growth in the horse genome mapping from the period of 2001 until the contemporary moment. Approximately 300 mapped markers on the 31 chromosome pairs including the X chromosome were present at the start. However, an exponential increase led the horse genome to be one of the best-mapped genomes amongst domestic animals.
  • The researchers highlight the creation of high-resolution, linearly-ordered gene maps for all autosomes, along with the X and Y chromosomes, providing an impressive level of detail in the genomic mapping of the horse.
  • About 4350 mapped markers distributed over the approximately 2.68 Gbp long equine genome were reported, offering an average of one marker every 620 kb. This level of detail in the mapping provides a comprehensive coverage.

Notable Developments in Equine Genome Analysis

  • Two crucial developments highlighted in the research were the availability of the assembled sequence (EquCab2) of the female horse genome and the generation of approximately 1.5 million single nucleotide polymorphisms (SNPs) across different breeds.
  • The availability of the assembled sequence and these SNPs triggered the creation of new tools, such as the 60K SNP-chip and whole genome expression microarrays. These tools are anticipated to facilitate studying the equine genome and transcriptome in unprecedented ways, enhancing the understanding of the genomic make-up of horses.

Potential Impact on Understanding Genetics and Improving Equine Health

  • The research expresses optimism that the advancements in the equine genome mapping and analysis will lead to improved accuracy and speed in studying the genetics underlying important monogenic traits, those attributed to a single gene.
  • Of larger interest are the prospects of studying complex or multigenic traits, which are determined by more than one gene, that have significant implications for equine health and welfare.
  • These enhancements in the understanding of the horse genome are anticipated to lead to improved diagnostics, prevention strategies, and therapeutic approaches for equine health issues, therefore potentially improving overall horse welfare.

Cite This Article

APA
Chowdhary BP, Raudsepp T. (2008). The horse genome derby: racing from map to whole genome sequence. Chromosome Res, 16(1), 109-127. https://doi.org/10.1007/s10577-008-1204-z

Publication

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
ISSN: 0967-3849
NlmUniqueID: 9313452
Country: Netherlands
Language: English
Volume: 16
Issue: 1
Pages: 109-127

Researcher Affiliations

Chowdhary, Bhanu P
  • Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843-4458, USA. bchowdhary@cvm.tamu.edu
Raudsepp, Terje

    MeSH Terms

    • Animals
    • Base Sequence
    • Chromosome Mapping
    • Chromosomes, Artificial, Bacterial / genetics
    • Female
    • Genome
    • Horses / genetics

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