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The Veterinary clinics of North America. Equine practice2010; 26(1); 125-133; doi: 10.1016/j.cveq.2010.01.002

Therapeutic hypothermia (cryotherapy) to prevent and treat acute laminitis.

Abstract: Digital hypothermia successfully reduces the severity of experimentally induced laminitis. Continuous-distal limb cryotherapy may be a useful technique in clinical cases that are at risk of developing laminitis. This article examines the effects of hypothermia on tissue as well as the rationale, and suggested protocols for the usage of distal limb cryotherapy in the prevention and treatment of laminitis.
Publication Date: 2010-04-13 PubMed ID: 20381741DOI: 10.1016/j.cveq.2010.01.002Google Scholar: Lookup
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Summary

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The research article examines the potential of therapeutic hypothermia (cryotherapy) as a preventive and treatment approach for acute laminitis, a painful disease affecting hooves of horses.

Introduction to Laminitis and Cryotherapy

  • Laminitis is a condition that primarily affects horses, causing severe pain and inflammation in the hooves. If left untreated, it can lead to lameness or even euthanasia in severe cases.
  • Cryotherapy, or therapeutic hypothermia, is a treatment method where cold temperatures are applied to certain parts of the body to reduce pain and inflammation.
  • The study investigates the impact of cryotherapy, applied to the distal limb (the lower part of the leg including the foot), in preventing and treating laminitis.

Application and Effectiveness of Cryotherapy

  • This research examines the aftermath of the application of cryotherapy to horses suffering from laminitis. Specifically, the study focuses on cryotherapy applied to the distal limb of the horse.
  • Findings suggest that continuous-distal limb cryotherapy can significantly reduce the severity of laminitis when the condition is artificially induced in experimental conditions.
  • This suggests that continuous-distal limb cryotherapy could potentially be a beneficial technique for treating horses that are at risk of developing laminitis.

Hypothermia and Tissue Interactions

  • The authors delve into the detail of how hypothermia impacts the tissues within the body. Lowering the temperatures in the distal limb could limit the metabolic and inflammatory processes that contribute to laminitis, thus helping in the reduction of inflammation and pain.

Recommended Protocols and Implications

  • The study suggested protocols for the use of distal limb cryotherapy in the prevention and treatment of laminitis.
  • These encompassed details pertaining to when, how, and for how long the cryotherapy should be applied to have the most beneficial effect.
  • This research has promising implications, as it offers a potentially effective treatment option for a disease that currently has limited and often ineffective treatment options.

Cite This Article

APA
van Eps AW. (2010). Therapeutic hypothermia (cryotherapy) to prevent and treat acute laminitis. Vet Clin North Am Equine Pract, 26(1), 125-133. https://doi.org/10.1016/j.cveq.2010.01.002

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 26
Issue: 1
Pages: 125-133

Researcher Affiliations

van Eps, Andrew W
  • School of Veterinary Science, University of Queensland, Slip Road, St Lucia, QLD 4072, Australia. a.vaneps@uq.edu.au

MeSH Terms

  • Acute Disease
  • Animals
  • Cryotherapy / methods
  • Cryotherapy / veterinary
  • Foot Diseases / pathology
  • Foot Diseases / prevention & control
  • Foot Diseases / therapy
  • Foot Diseases / veterinary
  • Hoof and Claw / blood supply
  • Hoof and Claw / pathology
  • Horse Diseases / pathology
  • Horse Diseases / prevention & control
  • Horse Diseases / therapy
  • Horses
  • Inflammation / pathology
  • Inflammation / prevention & control
  • Inflammation / therapy
  • Inflammation / veterinary
  • Severity of Illness Index
  • Treatment Outcome
  • Vasoconstriction / physiology

Citations

This article has been cited 10 times.
  1. O' Brien C, Pegg J. A Preliminary Investigation into Ridden Water Submersion Training as an Adjunct to Current Condition Training Protocols in Performance Horses. Animals (Basel) 2021 Sep 7;11(9).
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  2. Al Naem M, Litzke LF, Geburek F, Failing K, Hoffmann J, Röcken M. Effect of heel elevation on breakover phase in horses with laminitis. BMC Vet Res 2020 Oct 1;16(1):370.
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  3. de Laat MA, Reiche DB, Sillence MN, McGree JM. Incidence and risk factors for recurrence of endocrinopathic laminitis in horses. J Vet Intern Med 2019 May;33(3):1473-1482.
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  4. Roszkowska K, Witkowska-Pilaszewicz O, Przewozny M, Cywinska A. Whole body and partial body cryotherapies - lessons from human practice and possible application for horses. BMC Vet Res 2018 Dec 12;14(1):394.
    doi: 10.1186/s12917-018-1679-6pubmed: 30541547google scholar: lookup
  5. Mitchell CF, Fugler LA, Eades SC. The management of equine acute laminitis. Vet Med (Auckl) 2015;6:39-47.
    doi: 10.2147/VMRR.S39967pubmed: 30101095google scholar: lookup
  6. Morgan J, Stefanovski D, Lenfest M, Chatterjee S, Orsini J. Novel dry cryotherapy system for cooling the equine digit. Vet Rec Open 2018;5(1):e000244.
    doi: 10.1136/vetreco-2017-000244pubmed: 29344364google scholar: lookup
  7. Dern K, van Eps A, Wittum T, Watts M, Pollitt C, Belknap J. Effect of Continuous Digital Hypothermia on Lamellar Inflammatory Signaling When Applied at a Clinically-Relevant Timepoint in the Oligofructose Laminitis Model. J Vet Intern Med 2018 Jan;32(1):450-458.
    doi: 10.1111/jvim.15027pubmed: 29282770google scholar: lookup
  8. Wang L, Pawlak E, Johnson PJ, Belknap JK, Alfandari D, Black SJ. Effects of cleavage by a disintegrin and metalloproteinase with thrombospondin motifs-4 on gene expression and protein content of versican and aggrecan in the digital laminae of horses with starch gruel-induced laminitis. Am J Vet Res 2012 Jul;73(7):1047-56.
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  9. Hardefeldt L, Thomas K, Page S, Norris J, Browning G, El Hage C, Stewart A, Gilkerson J, Muscatello G, Verwilghen D, van Galen G, Bauquier J, Cuming R, Reynolds B, Whittaker C, Wilkes E, Clulow J, Burden C, Begg L. Antimicrobial prescribing guidelines for horses in Australia. Aust Vet J 2025 Dec;103(12):781-889.
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  10. Sikorska U, Maśko M, Rey B, Domino M. Utility of Infrared Thermography for Monitoring of Surface Temperature Changes During Horses' Work on Water Treadmill with an Artificial River System. Animals (Basel) 2025 Aug 1;15(15).
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