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Frontiers in veterinary science2022; 9; 833204; doi: 10.3389/fvets.2022.833204

Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations.

Abstract: The control of strongylid infections has become challenging globally for equine practitioners due to the development of anthelmintic resistance. Comprehensive information on anthelmintic resistance in the Czech Republic, however, is still lacking. This study monitored the current efficacy of fenbendazole, pyrantel embonate, ivermectin and moxidectin. Forty-eight of 71 operations met the criteria (≥6 horses with ≥200 eggs per gram), with 969 fecal egg count reduction tests performed. Anthelmintic resistance was evaluated on an operation level based on fecal egg count reduction (FECR) and the lower limit of the 95% credible interval (LLCI) using Bayesian hierarchical models. General anthelmintic efficacy across all operations was assessed by posterior FECRs and the occurrence of sub-zero efficacies. Ivermectin and moxidectin demonstrated excellent efficacy (FECR 99.8-100%; 99.4-100 LLCI) in 45 and 23 operations, respectively, pyrantel embonate demonstrated sufficient efficacy in 15 operations and resistance was suspected in seven operations (FECR 88.1-99.1%; 72.5-98.5 LLCI). Fenbendazole, however, was not effective in a single operation (FECR 19.1-77.8%; 8.1-50.1 LLCI) out of 18. Fenbendazole had the highest probability of sub-zero efficacy (29.1%), i.e., post-treatment fecal egg counts exceeded the pre-treatment counts. Our data indicate an increase in the development of anthelmintic resistance, resulting in total failure of fenbendazole and a reduced efficacy of pyrantel embonate. Introducing advanced approaches of parasite control in the Czech Republic to slow the spread of anthelmintic resistance is thus needed.
Copyright © 2022 Nápravníková, Várady and Vadlejch.
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Publication Date: 2022-02-21 PubMed ID: 35265696PubMed Central: PMC8899116DOI: 10.3389/fvets.2022.833204Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study investigates the developing resistance of horse strongylid infections to certain anthelmintics in the Czech Republic. The research found that fenbendazole failed to control the infection in all examined cases, while other drugs showed varying levels of effectiveness. The results underscore the need for advanced parasite control methods to combat growing anthelmintic resistance.

Research Context

  • The study focuses on the increasing global issue of anthelmintic resistance in controlling strongylid infections in horses. These infections are of notable concern to equine practitioners worldwide.
  • Anthelmintic resistance data for the Czech Republic is notably lacking, inspiring this research.
  • The researchers aim to monitor the effectiveness of four anthelmintics namely fenbendazole, pyrantel embonate, ivermectin, and moxidectin.

Research Procedure

  • Out of 71 Czech horse operations, 48 met the criteria to be included in the study, with each operation having at least 6 horses with an egg count of at least 200 per gram.
  • A total of 969 fecal egg count reduction tests were performed across all operations.
  • The researchers defined anthelmintic resistance at an operation level using fecal egg count reduction (FECR) and the lower limit of the 95% credible interval (LLCI) in a Bayesian hierarchical model.

Findings

  • Ivermectin and moxidectin demonstrated excellent efficacy in 45 and 23 operations, respectively, clearly reducing the fecal egg count.
  • Pyrantel embonate showed sufficient efficacy in 15 operations, but resistance was suspected in seven operations. This is determined by the FECR rate between 88.1-99.1% and LLCI of 72.5-98.5%.
  • The research found that fenbendazole was not effective in any of the 18 operations where it was used, showing FECR rates between 19.1-77.8% and LLCI of 8.1–50.1%. Moreover, fenbendazole had the highest probability of increasing post-treatment fecal egg counts (29.1%), indicating sub-zero efficacy.

Implications and Conclusion

  • The research indicates a growing issue of anthelmintic resistance in the Czech Republic, particularly with the total failure of fenbendazole and reduced effectiveness of pyrantel embonate.
  • These findings underline an urgent need to introduce advanced parasite control methods to slow down the spread of anthelmintic resistance.

Cite This Article

APA
Nápravníková J, Várady M, Vadlejch J. (2022). Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations. Front Vet Sci, 9, 833204. https://doi.org/10.3389/fvets.2022.833204

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 9
Pages: 833204

Researcher Affiliations

Nápravníková, Jana
  • Department of Zoology and Fisheries, Czech University of Life Sciences Prague, Prague, Czechia.
Várady, Marián
  • Institute of Parasitology, Slovak Academy of Sciences, Košice, Slovakia.
Vadlejch, Jaroslav
  • Department of Zoology and Fisheries, Czech University of Life Sciences Prague, Prague, Czechia.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Citations

This article has been cited 1 times.
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