Update of inactivated equine influenza vaccine strain in Japan.
Abstract: Japan established a vaccine selection system, in which a committee evaluates veterinary influenza vaccines to determine if the vaccine should be updated. In 2013, it was concluded that the present equine influenza vaccine strains did not have to be updated, but clade 2 (Fc2) viruses of the Florida sublineage should be included. We collected three Fc2 viruses as candidates and conducted comparative tests. Results indicated that A/equine/Carlow/2011 (H3N8) is not suitable, because of its unstable antigenic characteristics. A comparison between A/equine/Richmond/1/2007 (H3N8) (Richmond/07) and A/equine/Yokohama/aq13/2010 (H3N8) (Yokohama/10) in eggs showed that they shared equal growth properties. Immunogenicity test in mice showed that Yokohama/10 induced higher HI antibody titers than Richmond/07. Therefore, we concluded that Yokohama/10 was the most suitable strain.
Publication Date: 2017-02-06 PubMed ID: 28163276PubMed Central: PMC5383192DOI: 10.1292/jvms.16-0558Google Scholar: Lookup
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- Journal Article
Summary
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The study details the process and conclusions of an evaluation conducted in Japan regarding the updating of inactivated equine influenza vaccines, focusing on the inclusion of viruses from the Florida clade 2 (Fc2). The research concluded that, among three candidate Fc2 viruses, the A/equine/Yokohama/aq13/2010 (H3N8) (Yokohama/10) strain was found to be the most suitable for inclusion in the vaccine.
Vaccine Selection System in Japan
- Japan has an established system for selecting vaccine strains. This includes a committee that assesses veterinary influenza vaccines to determine whether the strains used in the vaccine need to be updated.
- In 2013, the committee decided that the existing equine influenza vaccine strains did not require an update. However, they recommended including the Fc2 viruses from the Florida sublineage.
Selection of Fc2 Viruses
- The researchers collected three Fc2 viruses as potential candidates for inclusion in the vaccine, and conducted comparative tests on these candidates.
- The A/equine/Carlow/2011 (H3N8) strain was deemed unsuitable for use in a vaccine due to its unstable antigenic properties.
Comparison of Richmond/07 and Yokohama/10 Strains
- A comparative study between the remaining two strains, A/equine/Richmond/1/2007 (H3N8) (Richmond/07) and A/equine/Yokohama/aq13/2010 (H3N8) (Yokohama/10), was performed using eggs.
- The growth properties of the two strains were found to be the same when cultured in eggs.
Immunogenicity Test in Mice
- The research performed an immunogenicity test using mice to determine which of the two strains was more likely to induce a higher immune response.
- The results showed that Yokohama/10 elicited higher HI antibody titers than Richmond/07, suggesting a more robust immune response.
- Based on these results, the researchers concluded that Yokohama/10 was the most suitable strain to include in the inactivated equine influenza vaccine.
Cite This Article
APA
Gamoh K, Nakamura S.
(2017).
Update of inactivated equine influenza vaccine strain in Japan.
J Vet Med Sci, 79(3), 649-653.
https://doi.org/10.1292/jvms.16-0558 Publication
Researcher Affiliations
- National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
MeSH Terms
- Animals
- Antibodies, Viral / blood
- Antibodies, Viral / immunology
- Antigens, Viral / immunology
- Horse Diseases / epidemiology
- Horse Diseases / immunology
- Horse Diseases / virology
- Horses
- Influenza A Virus, H3N8 Subtype / immunology
- Influenza Vaccines / immunology
- Japan / epidemiology
- Orthomyxoviridae Infections / epidemiology
- Orthomyxoviridae Infections / veterinary
- Orthomyxoviridae Infections / virology
- Ovum / virology
- Vaccines, Inactivated / immunology
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Citations
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