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The Veterinary clinics of North America. Equine practice2026; S0749-0739(25)00077-X; doi: 10.1016/j.cveq.2025.12.009

Updates on Seizures and Epilepsy in the Horse.

Abstract: The goal of this article is to provide the equine practitioners with a framework for a diagnostic algorithm for the patient presented with possible seizures/epilepsy. Using a comparative approach, a review of companion animal and human research is provided with the intention of expanding our current knowledge on seizure/epilepsy, as well as diagnostic and treatment strategies for equine patients.
Publication Date: 2026-02-25 PubMed ID: 41748399DOI: 10.1016/j.cveq.2025.12.009Google Scholar: Lookup
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Summary

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Updates on Seizures and Epilepsy in the Horse provide a diagnostic framework for equine practitioners by reviewing seizures and epilepsy knowledge from companion animals and humans to enhance understanding and guide diagnosis and treatment in horses.

Introduction and Objective

  • The article aims to assist equine practitioners in diagnosing and managing seizures and epilepsy in horses.
  • It highlights the need for a structured diagnostic algorithm specific to equine patients presenting with possible seizures or epilepsy.
  • The study utilizes a comparative approach, drawing on research in humans and companion animals to improve equine epilepsy understanding.

Comparative Approach and Review

  • The authors review existing literature on seizure mechanisms, classification, and treatment from human and small animal studies.
  • They aim to identify parallels and differences between species to better contextualize seizures seen in horses.
  • This broad perspective is intended to inform the development of equine-specific diagnostic criteria and treatment protocols.

Diagnostic Algorithm Framework

  • The article proposes a step-by-step approach for evaluating horses with possible seizures:
    • Initial clinical assessment including history and physical examination focusing on neurological signs.
    • Use of diagnostic tests such as EEG (electroencephalography), blood work, imaging (MRI/CT), and possibly CSF analysis.
    • Distinguishing true epileptic seizures from non-epileptic events (e.g., syncope, movement disorders).
  • This structured algorithm aims to enhance accuracy in diagnosis and avoid misclassification of seizure-like episodes.

Treatment Strategies

  • Guidance on treatment is given based on insights from human and companion animal epilepsy management.
  • Potential medications and their applicability to equine patients are discussed, considering safety, efficacy, and side effects.
  • Recommendations emphasize individualized treatment plans and monitoring for response and adverse effects.

Significance and Impact

  • By integrating knowledge across species, the article broadens the understanding of equine seizures and epilepsy.
  • It provides practical diagnostic and therapeutic tools to improve care and outcomes for horses affected by seizures.
  • The framework supports more informed clinical decisions and encourages further research in equine neurology.

Cite This Article

APA
Migliorisi A. (2026). Updates on Seizures and Epilepsy in the Horse. Vet Clin North Am Equine Pract, S0749-0739(25)00077-X. https://doi.org/10.1016/j.cveq.2025.12.009

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
PII: S0749-0739(25)00077-X

Researcher Affiliations

Migliorisi, Alessandro
  • Roaring Fork Equine Medical Center, Glenwood Springs, CO 81601, USA. Electronic address: acmigliorisi@gmail.com.

Conflict of Interest Statement

Disclosure The authors have nothing to disclose.

Citations

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