Planta medica2022; 89(6); 584-607; doi: 10.1055/a-1969-2440

Use of Milk Thistle in Farm and Companion Animals: A Review.

Abstract: Milk thistle, , is a medicinal plant grown for its bioactive compounds with well-documented antioxidant and hepatoprotective properties. Milk thistle has a well-established pharmacological reputation for treatments of human liver disease, but it is also used in animals. This review summarizes the experimental evidence of milk thistle's effects on animals when administered as silymarin extract (feed additive) or a feed ingredient, if administered as seed or expeller/cake with the seed residue still containing the bioactive components. The use as a feed additive or feed ingredient is motivated by the complexity of silymarin registration as a veterinary drug. In farm animals, the drug improves the animals' performance and product quality and oxidative stability, supports liver function during the productive life-cycle, improves gut-health and morphology, and can reduce intestinal pathogens. In dogs and cats, the treatment is focused on acute and chronic liver diseases including the detoxification processes and support of drug treatments including chemotherapy. In equine athletes, milk seed cake showed positive effects and a faster return of cortisol to the resting values before exercise occurred. In aquaculture, it confirms its usefulness in supporting animal health and performance. In certain studies it is not clear what has been administered, and the composition and doses are not always clearly reported. A few studies reported no effects, but none reported problems connected to milk thistle administration. However, the overall picture shows that the use of milk thistle results in improved or restored health parameters or better animal performance.
Publication Date: 2022-10-27 PubMed ID: 36302565DOI: 10.1055/a-1969-2440Google Scholar: Lookup
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Summary

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The research article is a review into the use of milk thistle in farm and companion animals, specifically its antioxidant and hepatoprotective properties that bring about various health benefits including improved liver function, oxidative stability, gut-health, and reduction of intestinal pathogens.

Introduction to Milk Thistle

  • Milk thistle is a medicinal plant known for its bioactive compounds. These compounds have robust antioxidant and hepatoprotective qualities – both championed for their positive effects on liver health.
  • While its use in treating human liver diseases is well-established, the article highlights that its use extends to animals as well.
  • Typically, milk thistle is administered to animals either as silymarin extract, which is a feed additive, or as a feed ingredient in the form of seed or expeller/cake with the active components still present.

Milk Thistle in Farm Animals

  • In farm animals, milk thistle is observed to improve animal performance and product quality, contributing towards better oxidative stability.
  • It supports liver function throughout these animals’ productive life-cycle, bolsters gut health and morphology, and is known to diminish intestinal pathogens.

Milk Thistle in Pets

  • Such benefits also translate to pets like cats and dogs. For these companion animals, milk thistle is mainly used to treat acute and chronic liver diseases.
  • Additionally, it aids in detoxification processes and lends support to drug treatments, including chemotherapy.

Milk Thistle in Equine and Aquatic Animals

  • The study further reports that milk thistle displays positive effects on equine athletes, facilitating a quicker return of cortisol to resting values post-exercise.
  • In the realm of aquaculture, milk thistle proves useful in supporting animal health and performance.

Caveats

  • Despite the overwhelmingly positive effects of milk thistle, the review points out areas of uncertainty in some studies. Specifically, it is unclear what form of milk thistle (silymarin extract, seed, expeller, etc.) was administered in some cases. The composition and dosage amounts are not always distinctly reported either.
  • There were a few studies which noted no observable effects of milk thistle, but no problems or negative side effects were reported in connection with its administration.

Conclusion

  • In conclusion, the overall evidence points to an improved or restored health parameter or superior animal performance as a result of using milk thistle.

Cite This Article

APA
Tedesco DEA, Guerrini A. (2022). Use of Milk Thistle in Farm and Companion Animals: A Review. Planta Med, 89(6), 584-607. https://doi.org/10.1055/a-1969-2440

Publication

ISSN: 1439-0221
NlmUniqueID: 0066751
Country: Germany
Language: English
Volume: 89
Issue: 6
Pages: 584-607

Researcher Affiliations

Tedesco, Doriana Eurosia Angela
  • Department of Environmental Science and Policy, University of Milan, Italy.
Guerrini, Alessandro
  • Department of Environmental Science and Policy, University of Milan, Italy.

MeSH Terms

  • Animals
  • Horses
  • Humans
  • Cats
  • Dogs
  • Milk Thistle / chemistry
  • Cat Diseases
  • Dog Diseases
  • Silymarin / pharmacology
  • Antioxidants / pharmacology
  • Liver Diseases / drug therapy

Conflict of Interest Statement

The authors declare that they have no conflict of interest.

Citations

This article has been cited 3 times.
  1. Liu ZP, Chao JR, Xu PT, Lv HY, Ding BY, Zhang ZF, Li LL, Guo SS. Lonicera flos and Cnicus japonicus extracts improved egg quality partly by modulating antioxidant status, inflammatory-related cytokines and shell matrix protein expression of oviduct in laying hens.. Poult Sci 2023 Apr;102(4):102561.
    doi: 10.1016/j.psj.2023.102561pubmed: 36867918google scholar: lookup
  2. Martello E, Perondi F, Bisanzio D, Lippi I, Meineri G, Gabriele V. Antioxidant Effect of a Dietary Supplement Containing Fermentative S-Acetyl-Glutathione and Silybin in Dogs with Liver Disease.. Vet Sci 2023 Feb 8;10(2).
    doi: 10.3390/vetsci10020131pubmed: 36851435google scholar: lookup
  3. Guerrini A, Tedesco DEA. Restoring Activity of Milk Thistle (Silybum marianum L.) on Serum Biochemical Parameters, Oxidative Status, Immunity, and Performance in Poultry and Other Animal Species, Poisoned by Mycotoxins: A Review.. Animals (Basel) 2023 Jan 17;13(3).
    doi: 10.3390/ani13030330pubmed: 36766219google scholar: lookup