New Pathophysiological Insights from Serum Proteome Profiling in Equine Atypical Myopathy.
ACS omega    January 29, 2024   Volume 9, Issue 6 6505-6526 doi: 10.1021/acsomega.3c06647
Kruse CJ, Dieu M, Renaud B, Franu00e7ois AC, Stern D, Demazy C, Burteau S, Boemer F, Art T, Renard P, Votion DM.Equine atypical myopathy (AM) is a severe environmental intoxication linked to the ingestion of protoxins contained in seeds and seedlings of the sycamore maple () in Europe. The toxic metabolites cause a frequently fatal rhabdomyolysis syndrome in grazing horses. Since these toxic metabolites can also be present in cograzing horses, it is still unclear as to why, in a similar environmental context, some horses show signs of AM, whereas others remain clinically healthy. Label-free proteomic analyses on the serum of 26 diseased AM, 23 cograzers, and 11 control horses were performed to provide i...