Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Environmental toxicology and pharmacology.
Publisher:
Elsevier Science B.V.,
Frequency: Six no. a year, 2001-
Country: Netherlands
Language: English
Start Year:1996 -
ISSN:
1382-6689 (Print)
1872-7077 (Electronic)
1382-6689 (Linking)
1872-7077 (Electronic)
1382-6689 (Linking)
Impact Factor
4.3
2022
| NLM ID: | 9612020 |
| (DNLM): | SR0086869(s) |
| (OCoLC): | 34630912 |
| Coden: | ETOPFR |
| LCCN: | 96649706 |
| Classification: | W1 EN986KJ |
OPTIMIZING EXTRACTION AND CONCENTRATION METHODS FOR LC-MS/MS ANALYSIS OF VETERINARY PHARMACEUTICALS IN EQUINE-ASSOCIATED ENVIRONMENTAL MATRICES. This study developed a method for the simultaneous quantification of six potentially environmentally toxic veterinary drugs: benzylpenicillin, acepromazine, flunixin, dexamethasone, ketamine and romifidine, in soils, sediments, equine faeces and natural waters. Three methods were compared for their extraction from solid matrices: Ultrasonic extraction (USE), QuEChERS and Accelerated Solvent Extraction (ASE). ASE method was optimized according to temperature and extraction cycles. Quantification was performed by LC-MS/MS. LC and MS parameters were optimized. The method was validated according t...
Heavy metals in horses: A review of the toxicity, clinical consequences and expected safe tissue concentrations. Trace elements arsenic, cadmium, lead, chromium, mercury, nickel, and zinc are high-density, naturally occurring metals notable for their toxicity and environmental persistence. Cadmium and mercury are particularly concerning due to their capacity for bioaccumulation and biomagnification within the food chain. Dispersed through both anthropogenic and natural sources, these elements pose significant threats to ecosystems and animal health. In equines, they induce oxidative stress by disrupting mitochondrial function, generating reactive oxygen species, and inhibiting antioxidant enzymes, leadin...
Large-scale study of blood markers in equine atypical myopathy reveals subclinical poisoning and advances in diagnostic and prognostic criteria. Equine atypical myopathy (AM) is a severe rhabdomyolysis syndrome primarily caused by hypoglycin A (HGA) and methylenecyclopropylglycine protoxins. This study aimed to refine diagnostic and prognostic criteria for AM while exploring apparently healthy cograzers. Blood samples from 263 horses, including AM cases (n= 95), cograzers (n= 73), colic horses (n= 19), and controls (n= 76), were analyzed for HGA, its toxic metabolite, and acylcarnitines profile. Diseased horses exhibited alterations in acylcarnitines that strongly distinguished them from controls and colic horses. Regression analyses i...
Optimised method for determination hypoglycine A in maple plant material by multidimensional gas chromatography/mass spectrometry. In 2018, more than 50 cases of horse death by equine atypical myopathy (AM) were reported in the Czech Republic. This disease is often associated with the toxin hypoglycine A (HGA), which is found in several maple plant materials. To monitor this toxin in products of these trees that grow in or around horse pastures, a rapid and inexpensive analytical method that can provide the required accuracy is needed. Until now, maple samples have been prepared for gas chromatography using time-consuming methods, with preparation processes taking longer than 1 h. In this work, a shorter method (25 mi...
In vitro effects of oxygen on physico-chemical properties of horse erythrocyte membrane. Whether direct exposure to different concentrations (0%, 13%, 100%) of oxygen may affect horse erythrocyte membrane fluidity (EMF) and fatty acid (FA) composition was studied during 1 (T60) and 2h (T120) exposure. EMF was investigated at the head group level and hydrophobic core thanks to phosphorus nucleus 31 ((31)P) nuclear magnetic resonance ((31)P NMR) and electronic paramagnetic resonance (EPR) using two spin probes: 5-nitroxydestearic acid and 16-doxylstearic acid. Lipid structure of the membranes was studied by gas liquid chromatography. 4-Hydroxy-2E-nonenal was also analyzed as a marke...
Disruption of sphingolipid metabolism and induction of equine leukoencephalomalacia by Fusarium proliferatum culture material containing fumonisin B(2) or B(3). Fumonisin B(1), B(2), and B(3) are inhibitors of ceramide synthase, a key enzyme in the pathway for de novo sphingolipid biosynthesis. Corn, naturally contaminated with either predominantly fumonisin B(1) or pure fumonisin B(1), has been shown to cause equine leukoencephalomalacia (ELEM). It has been hypothesized that fumonisin-induced disruption of sphingolipid metabolism is an early event in the development of ELEM. Recently, it was shown that Fusarium proliferatum corn culture diets containing predominantly fumonisin B(2), but not diets which were predominantly fumonisin B(3), at 75 ppm (0....
