English
French
Science translational medicine.
Publisher:
American Association for the Advancement of Science
Frequency: Monthly
Country: United States
Language: English
Author(s):
American Association for the Advancement of Science.
Start Year:2009 -
ISSN:
1946-6234 (Print)
1946-6242 (Electronic)
1946-6234 (Linking)
1946-6242 (Electronic)
1946-6234 (Linking)
Impact Factor
17.1
2023
| NLM ID: | 101505086 |
| (OCoLC): | 299570656 |
| LCCN: | 2009202156 |
| Classification: | W1 SC781Q |
Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models. Venezuelan and eastern equine encephalitis viruses (VEEV and EEEV, respectively) are mosquito-borne, neuroinvasive human pathogens for which no FDA-approved therapeutic exists. Besides the biothreat posed by these viruses when aerosolized, arthropod transmission presents serious health risks to humans, as demonstrated by the 2019 outbreak of EEE disease in the United States that resulted in 38 confirmed cases, 19 deaths, and neurological effects in survivors. Here, we describe the discovery of a 2-pyrrolidinoquinazolinone scaffold, efficiently synthesized in two to five steps, whose structural...
