Veterinary pathology.
Publisher:
Karger.. Thousand Oaks, CA : Sage (2010)
Frequency: Bimonthly
Country: United States
Language: English
Author(s):
American College of Veterinary Pathologists., Arbeitsgemeinschaft der Veterinärpathologen., European College of Veterinary Pathologists., Nihon Jūi Byōrigaku Senmonka Kyōkai.
Start Year:1971 -
ISSN:
0300-9858 (Print)
1544-2217 (Electronic)
0300-9858 (Linking)
1544-2217 (Electronic)
0300-9858 (Linking)
Impact Factor
2.4
2023
| NLM ID: | 0312020 |
| (DNLM): | V05980000(s) |
| (OCoLC): | 00932839 |
| Coden: | VTPHAK |
| LCCN: | 77646648 |
| Classification: | W1 VE933V |
Pi granules and related intracytoplasmic inclusions in equine Schwann cells. Suchwann cells from a variety of nerves in two adult horses and one adult pony contained perinuclear intracytoplasmic inclusion complexes consisting of lipid droplets, variably electron-dense rounded to elongated bodies and rod-shaped multilamellar structures. The latter were characteristic of pi granules of Reich. There were no significant axonal or myelin alterations associated with these inclusions. It was concluded that the inclusions are a component of normal equine Schwann cells.
Pathology of the vertebral column of horses with cervical static stenosis. Specimens of ligamentum flavum, joint capsule, and dorsal lamina were collected at surgery or necropsy from 25 horses with cervical static stenosis. All horses had myelographic evidence of dorsal compression of the spinal cord caused by soft tissue and/or bone in the caudal cervical area, primarily at C6-7. Most horses also had radiographic evidence of degenerative joint disease of articular facets. Histologically 19 horses had osteosclerosis and cartilage retention in the dorsal lamina, and 24 horses had increased fibrocartilage at the ligamentum flavum attachment to dorsal lamina. The ligame...
Enterocolitis caused by Ehrlichia sp. in the horse (Potomac horse fever). Potomac horse fever was reproduced in 15 ponies by transfusion of whole blood originally from two natural cases and subsequently from ponies infected by the transfusions. Incubation periods varied from 9 to 15 days. Affected ponies developed varying degrees of fever, diarrhea, anorexia, depression, and leukopenia. Eleven affected ponies were killed, three died in the acute phase of the disease, and one did not show clinical signs. The most consistent post-mortem findings were fluid contents in the cecum and large colon, and areas of hyperemia (of inconstant degree and distribution) in mucosae ...
Histochemical and morphometric evaluation of skeletal muscle from horses with exertional rhabdomyolysis (tying-up). Thirteen horses with histories of exertional rhabdomyolysis were exercised for 20 minutes to induce clinical signs of lameness, elevated serum creatine kinase (CK), and aspartate aminotransferase (AST) activities and skeletal muscle morphologic lesions. The clinical signs exhibited by affected horses included trembling, sweating, increased rate of respiration, and restricted limb movement. Serum CK reached maximal activity between 4 and 8 hours after the exercise period and serum AST activity peaked between 24 and 48 hours. Histologically, the skeletal muscle lesions in muscle biopsies 24 hour...
Ocular angiosarcoma in the horse: morphological and immunohistochemical studies. Angiosarcomas arising in ocular tissues of four aging horses are described. Tumors were locally invasive and eventually metastasized via the mandibular and cervical lymph nodes. Pathologically, the tumors contained well-differentiated regions, in which vascular channels were lined by pleomorphic endothelial cells, as well as poorly-differentiated regions, in which vascular channels were either rudimentary or absent. Red blood cells were scare in vascular structures formed by the tumors. Factor VIII related antigen (VIII:RAg), a blood vascular endothelial marker, was demonstrated by immunohisto...
Powassan viral encephalitis: a review and experimental studies in the horse and rabbit. Powassan virus strain M794, a member of the Flavivirus genus known to infect man and animals in Canada, was inoculated intracerebrally into rabbits and horses. No clinical signs were observed in rabbits, but widespread encephalitis resulted, characterized by lymphoid perivascular cuffing, lymphocytic meningitis, and lymphocytic choroiditis. In horses, eight days after inoculation, prominent neurological signs occurred and lesions were those of non-suppurative encephalomyelitis, neuronal necrosis, and focal parenchymal necrosis. The virus could not be reisolated from the rabbit or horse brains....
Endocarditis in six horses. Six horses (five males) aged three months to fourteen years had endocarditis at necropsy. Two of the horses had a clinical diagnosis of valvular endocarditis with negative blood cultures. Single or complex valvular involvement was present in five horses. One horse had non-infectious thrombi associated only with the chordae tendineae. Mitral valves were affected in four horses, and aortic semilunar valves were affected in two. Infarcts had occurred in the kidneys and the myocardium of four horses. Bacteria were isolated postmortem from the valvular vegetations of two horses; Candida parapsilosi...
Chronic eosinophilic dermatitis: a manifestation of a multisystemic, eosinophilic, epitheliotropic disease in five horses. A generalized, chronic, progressive, exfoliative dermatitis in five horses is described. Histologically, the lesion is characterized by a superficial and deep perivascular dermatitis which is eosinophil-rich with a marked lymphocytic and plasmacytic component, accompanied by marked acanthosis and hyperkeratosis. More severe cases progress to a lichenoid pattern with the same cellular composition with focal eosinophilic spongiosis and eosinophilic subcorneal pustules. Clinically, the disease is associated with chronic, severe weight loss and is fulminating. The skin lesions are accompanied by l...
Functional and biochemical characterization of immunologically derived equine platelet-activating factor. Antigen-specific challenge of equine leukocytes induced the non-lytic release of a platelet-activating factor in vitro. The equine platelet-activating factor stimulated the release of serotonin from equine platelets in a dose-responsive manner, independent of the presence of cyclo-oxygenase pathway inhibitors such as indomethacin. Rabbit platelets were also responsive to equine platelet-activating factor. The release of equine platelet-activating factor was a rapid reaction with near maximal secretion taking place in 30 seconds. Addition of equine platelet-activating factor to washed equine pl...
Intimal asteroid bodies in horses: light and electron microscopic observations. The morphology of asteroid bodies in equine arteries is demonstrated by light microscopy as well as by scanning and transmission electron microscopy combined with chemical analysis. Asteroid bodies first occur in horses at four weeks of age in all investigated tissues except the esophagus and always are located in the subendothelial space. The number, shape, ultrastructure and chemical composition of asteroid bodies differ markedly--depending on the age of the horse. Asteroid bodies are round and smooth in foals, but are shaped irregularly and have several projections and marked stratified cal...
Necrosis and rupture of the aorta and pulmonary trunk in four horses. Four horses are described with rupture of the aortic arch and pulmonary trunk which resulted in a fistula between these vessels. Ruptures were located near the ligamentum arteriosum. Histological examination of the vessel walls revealed media necrosis which was probably due to intimal thickening and/or medial fibrosis of the vasa vasorum.
Some unusual features of mesangioproliferative glomerulonephritis in horses. Seven horses ranging from three to 15 years of age had nephrotic syndrome; at necropsy, renal tissue of all seven horses had the morphologic lesions of mesangioproliferative glomerulonephritis (membranoproliferative glomerulonephritis). Homogeneous eosinophilic material which filled the glomerular capillary lumina was found in five horses. Ultrastructurally, this material primarily consisted of electron-dense deposits with a fibrillar pattern in five horses and in one horse, rhomboid crystalline deposits which resembled deposits seen in human cryoglobulinemia. The association of mesangioprolif...
Pathomorphology and pathogenesis of bacterial meningoventriculitis of neonatal ungulates. Bacterial meningoventriculitis was studied in 26 neonatal ungulates. Preceded by a substantial bacteremia, usually due to Escherichia coli, the fibrinopurulent inflammation involved leptomeninges, choroid plexuses, and ventricle walls, but largely spared the neuraxial parenchyma. It is proposed that this surface-relatedness results from the transport of bacteria by monocytes of low bactericidal power, migrating by normal pathways to maintain significant surface populations of macrophages. The neuraxial parenchyma is spared because of its normal lack of a macrophage population. A similar pathog...
Neuroaxonal dystrophy of the accessory cuneate nucleus in horses. Data were collected from 37 horses with a neurologic disability and compared to a group of 34 normal horses. Affected horses had neuroaxonal dystrophy, gliosis, vacuoles, and sometimes pigment localized to the accessory cuneate nuclei with minimal or no changes in the spinal cord and no changes in the proximal peripheral nerves. The focal nature of the change and usual absence of significant light microscopic spinal cord or peripheral nerve changes are different than previously described equine neuropathologic conditions.
Monocytic leukemia in a horse. On clinical examination, a six-year-old Hassian gray gelding with a history of impaired performance, slight cough, colic, and edema of the ventral abdomen, prepuce and the legs had reduced skin turgor, pale mucous membranes, forced costoabdominal breathing, reduced venous return, enlarged lymph nodes, and splenomegaly. Hematologic findings revealed anemia, leukocytosis and a high percentage of monocytoid leukemic cells. Generalized lymphadenopathy, splenomegaly, ascites, hydrothorax, and a diffusely thickened gut wall were found at necropsy. Massive infiltration with monocytoid leukemic cells ...