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Topic:Animal Studies
Animal studies involving horses encompass a range of research focused on understanding equine biology, behavior, and health. These studies often investigate various aspects of horse physiology, genetics, nutrition, and disease pathology. Researchers utilize animal studies to explore the effects of different treatments, management practices, and environmental factors on horse welfare and performance. The findings from such studies contribute to the development of improved care strategies and health interventions. This page gathers peer-reviewed research studies and scholarly articles that explore the methodologies, findings, and implications of animal studies conducted on horses, providing insights into their application in advancing equine science.
Effect of centrifugation and seminal plasma on motility and fertility of stallion and bull spermatozoa. The effect of centrifugation of diluted and undiluted semen on equine and bovine spermatozoan motility and fertility was examined, as was the effect of seminal plasma and dilution on stallion spermatozoa during incubation before and after freezing. Centrifugation at 370 g or 829 g was not detrimental (P greater than 0.05) to prefreeze or postfreeze motility if a final concentration of 10% seminal plasma was present. A reduction of seminal plasma from 10% to 2% significantly (P smaller than 0.05) reduced motility. A centrifugal force of 956 g significantly reduced prefreeze but not postfreeze m...
Ventilatory alterations in normal horses in response to changes in inspired oxygen and carbon dioxide. The influence of various concentrations of CO2 and O2 in the inspired gases on minute volume (V), tidal volume (VT), and respiratory rate (breaths per min; BPM) was examined in nonanesthetized, nonsedated normal horses. The VT and BPM increased linearly in response to increases in inspired CO2 concentration and curvilinearly in response to decreases in inspired Os concentration. The V increased curvilinearly in response to both increases in inspired CO2 concentration and decreases in inspired O2 concentration.
Identification of the lysine residue modified during the activation of acetimidylation of horse liver alcohol dehydrogenase. A single amino group in horse liver alcohol dehydrogenase was modified with methyl(14C)acetimidate by a differential labeling procedure. Lysine residues outside the active site were modified with ethyl acetimidate while a lysine residue in the active site was protected by the formation of an enzyme-NAD+-pyrazole complex. After the protecting reagents were removed, the enzyme was treated with methyl(14C)acetimidate. Enzyme activity was enhanced 13-fold as 1.1 (14C)acetimidyl group was incorporated per active site. A labeled peptide was isolated from a tryptic-chymotryptic digest of the modified...
Giant cell tumor of soft parts. A report of an equine and a feline case. Masses removed from the superficial fascia of the jugular groove of a 12-year-old Arabian mare and from the femoral canal of a 7 1/2-year-old female cat appeared to be counterparts of the human malignant giant cell tumor of soft parts, even recapitulating the clinical behavior of the respective subgroups. Histologically, both neoplasms contained the characteristic features of the malignant giant cell tumor of soft parts: large multinucleate giant cells, pleomorphic mononuclear giant cells, histiocytes, fibroblasts and fibrocytes that were sometimes sarcomatous, and foci of hemorrhage and necro...
Experimentally induced infection of dogs, cats, and nonhuman primates with Ehrlichia equi, etiologic agent of equine ehrlichiosis. Dogs (German Shepherd Dogs and Beagles), cates, rhesus macaques (Macaca mulatta), and baboons (Papio anubis) were inoculated with Whrlichia equi, the etiologic agent of equine ehrlichiosis. Within 3 to 7 days after inoculation, morulae were observed in the eosinophils of cats, neurtrophils of macaques and baboons, and in both neutrophils and eosinophils of dogs. The severe disease produced in horses by this agent was not a feature of E equi infection in dogs, cats, macaques, and baboons. However, a susceptible horse, inoculated with the pooled blood of 2 infected macaques, developed severe cli...
Hyperlipoproteinaemia in ponies: mechanisms and response to therapy. (I) The lipid and lipoprotein concentrations in sera of 4 healthy and 9 hyperlipaemic patients were determined. From the results of the analyses, it is suggested that three types of hyperlipoproteinaemia can be distinguished in ponies: (a) Type 1, characterised by a very pronounced increase in only the very low density lipoproteins (VLDL); (b) Type 2, in which there is a pronounced increase in the chylomicrons (Chylo) and the very low density lipoproteins (VLDL); (c) Type 3, which can be the result of fasting and is characterised by a moderate increase in the concentration of chylomicrons and ...
[Preparation and comparative evaluation of experimental anthrax diagnostic sera in experiments on animals]. The authors present the results of studies on obtaining and comparative assessment of experimental anthrax diagnostic sera in experiments on various animals. Donkeys, sheep, horses, rabbits and monkeys (Papio hamadryas) were immunized with the STI-I vaccine by a single scheme. The activity of the obtained sera was tested in the diffuse precipitation reaction by the amount of the detected antibodies and the titre. The most active sera were obtained from donkeys and sheep: their titre was 5.5 and 4 times greater and amount of the detected antibodies 2.6--2 times greater than in the sera of horse...
The sensitizing properties of anti-mouse anti-thymocyte horse serum. The authors have compared the anaphylaxis due to active and passive sensitization of mice. In the case of active sensitizing, anti-mouse anti-thymocyte horse serum (ATS), and/or normal horse serum (NHS), whereas in the case of passive sensitizing, plasma, peripheral leukocytes, spleen cells and thymocytes of sensitized animals were used. Provocation of shock was carried out by intravenous administration of ATS or NHS. Irreversible anaphylaxis occurred in a significantly higher rate in the case of ATS than NHS sensitivity, produced either actively, or passively. Differences have been found also...
[Cecal motricity and ceco-iliac transit in the horse]. Electrical spiking activity of the caecum is increased eight-fold and the rate of passage of digesta is increased four-fold when the volume of caecal contents is doubled. The role of caecal motility in regulating the volume of caecal contents is discussed.
Presence of the arteria caroticobasilaris in the horse. The consistent presence of the caroticobasilar artery was observed and discussed in view of the anatomical normalities in the horse. The persistence of the above vessel was correlated with the developmental changes in the cranial and cerebral arteries.
Hypoxic pulmonary hypertension in the pony. Hemodynamic measurements were made in 6 ponies at low altitude (Madison, WI, altitude, 250 m) and after 1, 2, 4, and 6 weeks at high altitude (Climax, CO, altitude, 3,400 m). The salient findings were that ponies maintain an increased heart rate and cardiac output and develop significant pulmonary hypertension at high altitude. The average control resting mean pulmonary artery pressure (BPpul) was 25.1 mm of Hg at 250 m; this value increased to 56.3 mm of Hg after 6 weeks at 3,400 m. An additional finding was that the pulmonary vascular response to acute hypoxia seemed to increase with time at...
Studies on equine immunoglobulins. IV. Immunoglobulins of the donkey. Donkey IgGa was isolated in purified form from normal and immune donkey sera by column chromatography on DEAE-cellulose. Isolated donkey IgGa and mixtures of (IgGa+IgGb) were used as antigens to prepare rabbit reagents specific for equine IgGa or IgGb. Antibodies present in sera obtained from a single donkey at various times during the course of hyperimmunization with BSA were isolated by immuno-adsorption. The class or subclass of immunoglobulins present among isolated, donkey anti-BSA antibodies was determined by use of specific rabbit anti-equine immunoglobulin reagents. The homologues of h...
Molecular properties of multiple forms of acid phosphatase from horse liver. 1. Horse liver acid phosphatase was separated into two partially purified fractions differing in molecular weight (enzyme I about 100 00, enzyme II about 25 000). 2. Enzyme I was separated into several subfractions by DEAE-cellulose chromatography and isoelectric focusing. 3. Molecular weight, sedimentation coefficient and effective molecular radii were determined for acid phosphatases I and II by gel filtration and density-gradient centrifugation.
Arteria intercarotica caudalis and its homologue in the domestic animals. The arteria intercarotica caudalis was observed to be present in the dog, horse and cat but was reticulated in the case of cattle, sheep, goat, and pig. The latter structure was a homologue of the former and represented an important intercarotid communication present in most of vertebrate.
Systolic time intervals in domestic ponies: alterations in a case of coarctation of the aorta. This report describes the measurement of systolic time intervals in a nine year old female domestic pony which was found at necropsy to show coarctation of the aorta and bilateral ventricular hypertrophy. Electrocardiogram, phonocardiogram and direct arterial blood pressure were recorded from the pony in a standing unmedicated state and systolic time intervals were measured from the resulting tracings. A prolongation of left ventricular ejection time and shortening of the pre-ejection period were observed in comparison to a group of normal ponies similarly examined. Such changes are consistent...
Experimental studies on osteoporosis. Nutritional secondary hyperparathyroidism (NSH) defines a spontaneous and experimental disease in most domesticated and in some wild animals, caused by dietary calcium deficiency and/or phosphorus excess. Calcium deficiency results directly in hypocalcemia, and phosphorus excess induces hyperphosphatemia which causes hypocalcemia. Secondary hyperparathyroidism thus results and the plasma parameters return to normal and are maintained but only at the expense of progressive bone loss. The bone loss is generalized but the bones are not uniformly affected. The hierarchy of bone loss is, in decreas...
