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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
A comparison of three methods of end-to-end anastomosis in the equine small colon. Six animals were used to compare simple interrupted, simple continuous, and stapled techniques for end-to-end rotated small colon anastomoses. Three ponies were evaluated three days after surgery for adhesion formation and luminal diameter at each anastomosis site. Two ponies and one horse were evaluated 14 days after surgery for adhesion formation. All anastomosis sites were examined histologically for alignment of tissue planes, and evidence of inflammation. No single technique was superior in all areas examined. While only three of the nine anastomoses had mild fibrinous adhesions at three ...
Efficacy of water vapor-saturated air in the treatment of exercise-induced pulmonary hemorrhage in Thoroughbred racehorses. The efficacy of water vapor-saturated air as a treatment for horses with exercise-induced pulmonary hemorrhage (EIPH) was studied. Horses selected for study (n = 14) had grade 1 or greater hemorrhage in the trachea after a minimum of 4 breezes between 0.8 and 1 km, as determined by endoscopy. Nine horses were treated with water vapor-saturated air; 5 horses were not treated. When the mean and maximal EIPH scores from the pretreatment period were compared with the mean and maximal EIPH scores from the treatment period in both treated and nontreated groups, there was no significant difference be...
Evaluation of a test kit for determination of serum immunoglobulin G concentration in foals. The accuracy of an immunoglobulin (Ig) G test kit for the semiquantitative measurement of IgG concentration was evaluated with serum from 88 foals. Failure of passive transfer (IgG less than 400 mg/dl) was correctly identified in each of 34 samples, and partial failure of passive transfer (400 less than or equal to IgG less than 800 mg/dl) was correctly identified in each of nine samples. Evidence of adequate passive transfer (IgG greater than or equal to 800 mg/dl) was detected in 44 of 45 samples. One sample with 800 mg/dl or more of IgG was incorrectly classified as a partial failure of pas...
An outbreak of American cutaneous leishmaniasis (Leishmania braziliensis braziliensis) in a periurban area of Rio de Janeiro city, Brazil: clinical and epidemiological studies. From July 1984 to September 1986, 105 cases of American cutaneous leishmaniasis were studied in a locality closely situated to an urbanized area of the city of Rio de Janeiro, Brazil. Settlement in this area was established at least 20 years ago but the first cases were noted six months prior to the beginning of this study. Cases were almost exclusively cutaneous and ulcerated, with one to six months of evolution. Montenegro's skin tests were positive in all cases and anti-Leishmania antibodies were detected by indirect immunofluorescence test in 74.3% of the patients. Parasites were demonstra...
Treatment of Fasciola hepatica infection in horses with triclabendazole. Thirteen thoroughbred foals with an adult infection and a presumed immature infection with Fasciola hepatica were treated with 12 mg triclabendazole/kg bodyweight. The absence of eggs from samples of faeces examined at intervals up to 110 days after treatment showed that all the animals were cured. In a second trial the same dose of triclabendazole cured 11 of 12 foals whereas nitroxynil at 7 mg/kg cured only six of 12 foals. No side effects were observed after treatment.
Laminectomy for relief of atlantoaxial subluxation in four horses. Malalignment of the atlas and axis was seen in 4 horses with an idiopathic form of atlantoaxial subluxation characterized by spinal cord compression on extension. The bone structure and density of the atlas and axis were radiographically normal in 3 of the 4 horses. Clinical signs appeared when the horses were 6 to 30 months old, and 3 of the 4 horses had a history of trauma. Although a congenital anomaly could not be ruled out, the cause was thought to be trauma. The horses were moderately to severely ataxic at the time of examination. Myelography revealed compression of the spinal cord at th...
Variable locations of nutrient foramina of the proximal phalanx in forelimbs of standardbreds. Bilateral metacarpophalangeal radiographs of 100 Standardbreds were examined for visualization and location of nutrient foramina of the proximal phalanx. Foramina were located in the dorsal or palmar cortex or were not visible radiographically. Of 100 horses, 45 had bilaterally symmetrical foramina. Left and right proximal phalangeal foramina were asymmetrical in the remaining 55 horses. Of 200 proximal phalangeal foramina (in 100 horses), 78 were in the dorsal cortex, 61 were in the palmar cortex, and 61 were not visible radiographically. A significant (P = 0.05) effect of age or sex could no...
Intramuscular injection techniques and the development of clostridial myositis or cellulitis in horses. A survey of 584 veterinarians in equine practice was performed to determine their intramuscular injection techniques and the influence of those techniques on the development of clostridial myositis or cellulitis. Usable responses were obtained from 439 veterinarians (75.2%). Of these, 414 used a new needle and syringe for each injection, 241 swabbed the site with a cleansing/disinfectant agent, and 242 swabbed the top of multidose injection bottles with a similar solution. Only 2 clipped the hair at the injection site. Twenty eight of the respondents reported that at least 1 horse developed a ...
Detection of endotoxin in cases of equine colic. The Limulus amoebocyte lysate assay was used to test for the presence of endotoxin in 37 clinical cases of equine colic. Positive plasma titres were detected in 10 cases and the presence of endotoxin was significantly correlated with a high heart rate, a high packed cell volume and a poor prognosis. High levels of endotoxin were detected in gut contents taken from several sites in the gastrointestinal tract of normal horses.
Pulmonary micro-embolism following orthopaedic surgery in a Thoroughbred gelding. A NUMBER of post general anaesthetic complications are
known to occur in the horse and are well documented (Heath
1981). These include post anaesthetic forelimb lameness o r
ischaemic myopathy (so-called 'radial paralysis') (Trim and
Mason 1974) and spinal cord degeneration (Brearley, Jones,
Kelly and Cox 1986). The only postoperative respiratory
complication which has been documented in the horse is
postoperative hypoxaemia (Gillespie, Hall and 3 1 e r 1969;
Waterman, Jones and Richards 1982).
In a report of the post mortem examinations of 185 injured
human patients who died followi...
The hock as a potential site for non-invasive bone measurement. An in vitro study on the calcaneus of adult horses (n = 5) and foals (n = 10) was carried out using radiographic photodensitometry, single photon absorptiometry, transmission ultrasound velocity and chemical analysis. Data for trabecular bone content, ash, calcium and phosphorus levels were obtained. As techniques for assessing bone quality, ultrasound velocity was not sufficiently sensitive nor accurate and radiographic photodensitometry was found to be limited value. Photon absorptiometry was both accurate and reproducible, although some variation in bone mineral content and bone mineral den...
Combined use of detomidine with opiates in the horse. The effects of administration of one of four opiates (pethidine 1 mg/kg bodyweight (bwt), morphine 0.1 mg/kg bwt, methadone 0.1 mg/kg bwt, and butorphanol 0.05 mg/kg bwt) given intravenously to horses and ponies already sedated with detomidine (10 micrograms/kg bwt) were investigated. Behavioural, cardiovascular and respiratory effects of the combinations were compared with those occurring with detomidine alone. Addition of the opiate increased the apparent sedation and decreased the response of the animal to external stimuli. At doses used, butorphanol produced the most reliable response. Sid...
Comparison of staple and suture techniques for end-to-end anastomosis of the small colon in horses. Two techniques for end-to-end anastomosis of the small colon were evaluated in each of 6 horses. A simple interrupted suture pattern that excluded the mucosa and was oversewn with an inverting suture was compared with a triangulated double-row pattern of stainless steel staples. Anastomotic sites were evaluated at 2 weeks, 2 months, and 6 months for extent of abdominal adhesions, lumen diameter at anastomotic sites, bursting pressures, and healing response. Clinical postoperative complications were not associated with either technique. At postmortem examination, there was extensive adhesion fo...
Cardiorespiratory and sedative effects of a combination of acepromazine, xylazine and methadone in the horse. Cardiorespiratory and sedative effects of a combination of acepromazine, xylazine and methadone were studied in the horse. Acepromazine and xylazine produced cardiovascular effects whereas methadone mainly affected respiratory rate. Decreases in heart rate, arterial blood pressure and respiratory rate were seen. Sedation was superior to that of acepromazine, xylazine or a combination of these. No serious side effects were seen.
