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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Detection of neurectomy by testing skin sensitivity using an electrical stimulus. A method for detection of neurectomy by electrical stimulation of the skin, distal to the neurectomy site, was tested for accuracy and feasibility. An electrical stimulation device was designed and tested to find the minimum peak voltage that would elicit a response in normal horses. Twenty seven horses were then tested at regular intervals following neurectomy and their responses recorded. Immediately following neurectomy there was an area of insensitivity with sharply defined borders extending in an arc from the back of the pastern down towards the bulbs of the heels. In the months following...
ADCC and complement-dependent lysis as immune mechanisms against EHV-1 infection in the horse. Immunity to equine herpesvirus type 1 (EHV-1) was evaluated using sera collected from yearling horses involved in a trial of a commercial vaccine. Measurement of the ability of these sera to mediate antibody-dependent cellular cytotoxicity and complement-dependent lysis revealed that these mechanisms, although potentially important in recovery from EHV-1 infection, do not play a role in protection following vaccination.
Ruptured inguinal hernia in new-born colt foals: a review of 14 cases. Over a six year period, 14 new-born colt foals were treated surgically because of ruptured inguinal hernia. In all cases, the prolapsed intestines, which were jejunal loops, were situated subcutaneously and protruded through a rent in the parietal vaginal tunic at the level of the inguinal canal. After herniorrhaphy and unilateral castration, the prolapsed loops were replaced into the abdomen, and the superficial inguinal ring closed. Seven foals survived.
Effects of xylazine and acepromazine on bronchomotor tone of anaesthetised ponies. The effects of xylazine (an alpha 2-adrenoceptor agonist) and acepromazine (an alpha-adrenoceptor antagonist) on bronchomotor tone were investigated in seven anaesthetised, apnoeic ponies using a computer aided forced oscillation technique, which separates changes in bronchial calibre from changes in lung volume. Both agents produced bronchodilatation and a decrease in lung volume.
Evaluation of the post-partum mare in relation to foal heat breeding. II. Uterine swabbing and biopsies. Fifty-three post-partum (p. p.) periods were studied in 38 mares. Uterine samples were taken on
the 2nd and 5th days p.p. and thereafter every other day until ovulation. Uterine swabs were
examined for bacteria and neutrophils and uterine biopsy specimens for neutrophils and lymphocytes.
The occurrence of bacteria and leukocytes was most common on day 5 p. p. The dominant organism
on day 2 was E. coli and on day 5 P-haemolytic streptococci. Thirty-four mares were inseminated
during the first p. p. oestrus. Only the occurrence of neutrophils in day 5 biopsy specimens correlated
with foal ...
Increased local IgA production in chronic obstructive pulmonary disease. The immunoglobulin (Ig) content of serum and tracheal lavage fluid was measured in 50 horses suffering from chronic obstructive pulmonary disease (COPD) and 40 control horses. The mean immunoglobulin: albumin ratios of the lavage fluids of both groups were significantly higher than the corresponding values for serum, which indicates significant local production of immunoglobulins in the lower respiratory tract. The IgA: albumin ratio of lavage fluid was significantly higher in diseased compared with normal horses, which implies increased local production of IgA in this disease. The IgG: albumi...
Plasma and synovial fluid concentrations of gentamicin in horses after intra-articular administration of buffered and unbuffered gentamicin. The concentration of gentamicin in plasma and synovial fluid of normal adult horses was measured periodically for 24 hours after IV (2.2 mg/kg of body weight), intra-articular (IA; 150 mg), and simultaneous IV and IA administrations. Gentamicin also was buffered with sodium bicarbonate (3 mEq) and then was administered IA and simultaneously IV and IA. Synovial fluid specimens were obtained via an indwelling catheter placed into the antebrachiocarpal joint. The peak mean plasma gentamicin concentration (8.30 micrograms/ml) after IV administration was significantly (P less than 0.05) greater tha...
Quantification of skin displacement near the carpal, tarsal and fetlock joints of the walking horse. A technique enabling simultaneous visualisation of skin and underlying bony structures in the walking horse was used to quantify skin displacements on the lateral surface of carpal, tarsal and fetlock joints. The technique employed implanted light-emitting-diodes (LEDs) for marking the bone, and self adhesive spot labels for marking the overlying skin. Photographic recordings were made. Skin displacement was measured in six Dutch Warmblood horses. Mean total displacements and mean displacement per degree of change of joint angle were calculated. Displacements at the level of the fetlock joints...
Effect of gentamicin sulfate and sodium bicarbonate on the synovium of clinically normal equine antebrachiocarpal joints. The effect of gentamicin sulfate, unbuffered and buffered with sodium bicarbonate, on synovial fluid and membrane of clinically normal equine joints was evaluated. Thirty-six adult horses with clinically normal antebrachiocarpal joints were allotted to 6 treatment groups of 6 horses each. One antebrachiocarpal joint in each horse was chosen for treatment. Group-1 horses were given gentamicin (3 ml; 50 mg/ml); group-2 horses were given sodium bicarbonate (3 ml; 1 mEq/ml); group-3 horses were given gentamicin (3 ml; 50 mg/ml) and sodium bicarbonate (3 ml; 1 mEq/ml); group-4 horses were not treat...
Effects of xylazine on cecal mechanical activity and cecal blood flow in healthy horses. Mechanical activity of the cecal body, lateral cecal arterial blood flow, carotid arterial pressure, and heart rate were measured in 6 conscious healthy horses 30 minutes before and for 120 minutes after IV administration of xylazine at dosages of 1.1 mg/kg of body weight, 0.55 mg/kg, and 0.275 mg/kg. Xylazine at a dosage of 1.1 mg/kg reduced the mean motility index (the product of the mean amplitude of contractions and the total duration of contractile activity divided by the recording time) of the circular and longitudinal muscle layers for the first, second, third, and fourth 30-minute peri...
Secretion rates and short-term patterns of gonadotrophin-releasing hormone, FSH and LH in the normal stallion in the breeding season. Pituitary venous blood was collected by a painless nonsurgical cannulation method from five ambulatory stallions at 5-min intervals for 5-6 h during the breeding season. In four adult stallions, statistical analysis showed that pulses of gonadotrophin-releasing hormone (GnRH) and LH were coincident (P less than 0.01), as were pulses of FSH and LH (P less than 0.05). Furthermore, the patterns of changes in concentration of FSH and LH were highly correlated in each of the four stallions. However, seemingly ineffective pulses of GnRH were also observed, with 28% of GnRH pulses failing to induce a...
Further studies on the diagnostic value of gamma-glutamyl transpeptidase and 5′-nucleotidase in cattle, sheep and horses. The distribution of 5'-nucleotidase (5'-NT) and gamma-glutamyl transpeptidase (gamma-GT) is similar in the tissues of the sheep, calf and horse, except that there is relatively less gamma-GT in calf liver than in the liver of the other two species. The liver lesion produced by the oral administration of chloroform is similar in the three species and is accompanied by the release of 5'-NT into the plasma of the sheep and calf but not of the horse. Conversely, gamma-GT is released into plasma of the horse but not of the sheep or calf. This difference is not related to the tissue distribution of ...
A modified Cloward’s technique for arthrodesis of the normal metacarpophalangeal joint in the horse. A modified Cloward's technique was performed for arthrodesis of one metacarpophalangeal (MCP) joint in eight horses. Dorsal arthrotomies were performed medial and lateral to the common digital extensor tendon and two 16 mm holes were drilled through the joint. A perforated cylindrical stainless steel basket filled with cancellous bone was impacted into each hole. The limbs were supported in casts for 8 weeks. The joints were examined and radiographed at 4 weeks, 8 weeks, 6 months, and 10 months. One horse was euthanatized at week 14 to assess the progress of the arthrodesis. In the other seven...
Distribution of ground reaction forces of the concurrently loaded limbs of the Dutch Warmblood horse at the normal walk. The distribution of the ground reaction forces (GRF) over the concurrently loaded limbs of the normally walking horse was determined from 'representative' GRF patterns of all limbs, which were plotted in correct time order after analysis of simultaneously taken high-speed film. This procedure visualises the GRF patterns of each of the four limbs in relation to the GRF pattern(s) of the one or two concurrently loaded limb(s) during a complete stride. In 15 clinically sound horses the mean averaged GRF data and temporal stride parameters showed an almost complete symmetry between both the foreli...
Cardiovascular effects of hydralazine HCl administration in horses. Six standing awake adult horses were instrumented for measurement of mean arterial, central venous, and pulmonary arterial blood pressures (mm of Hg), thermodilution cardiac output (ml/kg/min), and pulmonary arterial blood temperature (C). Total peripheral resistance was calculated from these values. Base-line data were accumulated, and a single dose of hydralazine HCl (0.5 mg/kg) was administered IV. Horses were monitored for 420 minutes after hydralazine administration. Mean arterial and central venous blood pressures did not change from the base-line values. Cardiac output and heart rate we...
Procoagulant activity in respiratory tract secretions from horses with chronic pulmonary disease. Cell-free supernatants (sol phases), obtained after centrifugation (50,000 x g for 45 minutes) of respiratory tract secretions from horses with chronic pulmonary disease, were assayed for procoagulant activity (PCA) in a one-stage clotting assay. Of the 103 specimens tested, 59% (61) contained PCA. Procoagulant activity was detected most often in respiratory tract secretions of severely affected horses and was correlated with the quantity of neutrophils in the respiratory tract secretions. In 12 of the 17 secretions tested, the clotting time was decreased in a dose-dependent manner. However, i...
Consolidating pneumonia and pneumothorax in a horse. A 3-year-old Thoroughbred mare with signs of acute abdominal pain and chronic pneumonia was found to have pneumothorax. A single application of suction was successful in resolving the pneumothorax. The underlying pneumonia was treated with long-term antibiotic administration selected on the basis of results of bacteriologic culture and antimicrobial susceptibility testing of a transtracheal aspirate. The pneumonia resolved, and the mare returned to competition as a show hunter.
Generalised steatitis in an adult pony mare. Equine steatitis is a rare condition which is usually reported in foals. A case of generalised steatitis in an adult pony mare is described and compared with steatitis in other species. It is concluded that the condition resembled that recorded in foals but that its aetiopathogenesis remains obscure.
Embryonic loss in pony mares induced by intrauterine infusion of Candida parapsilosis. Pony mares which were detected pregnant by transrectal ultrasonography received a single intrauterine infusion of either sterile saline (control, n = 12 mares) or 10(6)Candida parapsilosis (treated, n = 12 mares) between Days 11 to 14 postovulation. Subsequent embryonic loss was studied by daily ultrasonography of the mare's uterus, by serum progesterone levels, by endometrial swabs for cytologic and microbiologic examination and by endometrial biopsies that were taken after embryonic loss was detected. Significantly fewer (P<0.01) embryonic losses occurred in control than in treated mares ...
Subclinical lumbar polyradiculopathy in multiple aged mammalian species. Lumbar polyradiculopathy, characterized by ballooning myelin sheaths was diagnosed in multiple aged mammalian species including two horses, a cow, a squirrel, a woodchuck, a rabbit, a guinea pig, a hamster, and a mouse. The lesion was subclinical, and considered an incidental, age-related finding.
