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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Isolation of antibiotic-resistant Salmonella krefeld from clinical veterinary materials. Six isolations of Salmonella krefeld were made from clinical veterinary specimens. These isolates were multiply resistant to several antimicrobial agents commonly used to treat salmonellosis.
Fatty acid composition of equine plasma. Fatty acid composition of plasma lipids of normal horses was determined. Four fatty acids (C16:0, C18:0, C18:1, and C18:2) comprised 86.73% of the total, with C18:2 comprising 44.04% of the total. Eight other fatty acids were found in small amounts. Unsaturated fatty acids constituted 66% of the total. Marked variation was demonstrated in fatty acid occurrence and distribution in the sterol ester, triglyceride, phospholipid, and free fatty acid fractions.
Lymphocyte transformation test in veterinary clinical immunology. Lymphocyte transformation test is a powerful tool in laboratory testing of immunologic competence of animals. The impaired function of the lymphocytes or presence of mitogenesis suppressing factors in the patient serum were detected by comparing lymphocyte transformation (expressed as thymidine incorporation) obtained in media containing either autologous, homologous, or fetal calf serum additions. Most valuable results were obtained by using at least two, preferably three, different phytomitogens: concanavalin A (Con A), pokeweed mitogen (PWM), and phytohemagglutinin (PHA) at optimal concentr...
A method of electro-acupuncture treatment for equine intestinal impaction. A method of electro-acupuncture for treatment of intestinal impaction of the horse was reported. The unique technique of the treatment includes deep needle insertion and the "triple tetanic treatment." Possible mechanism of this form of treatment was discussed.
Regional pulmonary perfusion in horses: a comparison between anaesthetised and conscious standing animals. The regional perfusion to the lungs of 14 ponies was studied using radioactively labelled microspheres injected intravenously. It was found that within half an hour of induction of anaesthesia the perfusion to the dependent lung had decreased significantly from the values in the standing animal. When anaesthesia was maintained for more than two and a half hours, however, the lung perfusions were not significantly different from the standing values when the animals were lying in lateral or supine recumbency.
Volume of the synovia in certain joint cavities in the horse. A method of determining the volumes of synovia in certain articular cavities in the horse is described. The method is based on the degree of dilution of human serum albumin labelled with I that is injected into the joint. It is shown that uniform distribution of the injected substance is attained within 20 min post injection. The elimination of the labelled substance was found to follow the pattern of a single exponential function. The following volumes of synovia were determined (mean ± s) : hock, 39.8 ± 2.1 ml; radio-carpal, 12.6 ±1.5 ml; intercarpal, 14.9 ± 0.6 ml; foreleg fetlock joint...
[Localization of beta-n-acetylhexosaminidase in stallion epididymis (author’s transl)]. The localization of beta-N-acetylhexosaminidase activity in 6 different segments of the epididymis was investigated in 8 stallions using biochemical and histochemical methods. The highest enzyme activity was found in segment D while the other segments displayed a much weaker reaction There was no or only low enzyme activity present in the epididymal fluid of the proximal 3 segments, whereas it was high in the distal 3 segments. The biological function of beta-N-acetylhexosaminidase in the epididymis is discussed briefly.
Susceptibility of Haemophilus equigenitalis, the causal agent of contagious equine metritis, to 31 antimicrobial agents. The minimal inhibitory concentrations of 31 antimicrobial agents were determined for 99 isolates of Haemophilus equigenitalis by the agar dilution method. All the isolates showed good susceptibility to 26 antimicrobial agents tests, minimal inhibitory concentrations of which were less than 3.13 micrograms/ml for more than 90% of the isolates. Of these agents, 4 macrolides (erythromycin, oleandomycin, kitasamycin, tylosin), 3 tetracyclines (tetracycline, chlortetracycline, oxytetracycline), 1 peptide (colistin), 1 penicillin (ampicillin) and 1 pleuromutilin (tiamulin) were the most active agent...
The metabolism of promazine and acetylpromazine in the horse. Promazine hydrochloride and acetylpromazine maleate were administered intravenously at clinical dose levels to horses. In urine from horses given promazine hydrochloride, the parent drug and four metabolites were detected. The two major metabolites, present as conjugates were identified after hydrolysis by beta-glucuronidase/arylsulfatase as 3-hydroxypromazine and 3-hydroxydesmonomethyl-promazine. Conjugated 3-hydroxypromazine has been previously identified as a major metabolite in the horse. Two minor metabolites isolated in this study were primaizine N-oxide and promazine N-oxide sulfoxide. ...
A preliminary report on an attempt to modify behavior of untamed ponies by acupuncture. A preliminary study using various acupuncture techniques to modify behavior of untamed ponies was attempted. In five of the seven tested parameters, the animals's behavioral responses were unaffected by acupuncture treatments. However, substantial improvement of general behavior of the nervous ponies was observed in animals treated with jaw and scutiform points. The results are not conclusive and further testing of acupuncture as a mean of modifying animal behavior is desirable.
Anthelmintic treatment of equids: capabilities and limitations. Critical tests of nine anthelmintic agents on ponies. A number of good anthelmintic drugs are currently available which eliminate gastrointestinal nematodes of equids with over 90% success. This is shown by comparing results of critical tests conducted with 9 anthelmintic agents on ponies using the following dosages: 19 mg/kg for Pyrantel embonate, 10 mg/kg for Oxfendazole, 10 mg/kg for Mebendazole, 5 mg/kg for Albendazole, 40 mg/kg for Dichlorvos, 44 mg/kg for Thiabendazole, 7.5 mg/kg, for Fenbendazole, 20 mg/kg for Cambendazole and 7 mg/kg for Parbendazole. From 6 to 9 ponies were treated with each of these anthelmintic agents. Based on total a...
