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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
The effect of exogenous oxytocin on luteal function in mares. Daily injections of 150 units oxytocin administered to 6 mares on Days 4, 5, 6, 7 and 8 after ovulation (Day 0 = ovulation) failed to induced luteolysis as indicated by the maintenance of normal plasma progestagen concentrations and the occurrence of normal ovulatory intervals. Three additional mares were given oestrogen injections 24 h before an injection of oxytocin on Day 7 after ovulation, but this treatment also failed to induce luteolysis since plasma progestagen concentrations were maintained in all three mares. Two mares exhibited normal ovulatory intervals, while the third developed a...
Critical anthelmintic trials in ponies with oxfendazole and caviphos and concomitant studies on the spontaneous elimination of small strongylids. The efficacy of the benzimidazole, oxfendazole, and the organophosphate, caviphos, against gastrointestinal parasites of ponies was evaluated by the critcial test method. Oxfendazole (10 mg/kg of body weight) given in single oral doses was 100% effective against adult large strongylids (Strongylus vulgaris, Strongylus edentatus, and Strongylus equinus), 99% effective against adult small strongylids, and 97% effective against 4th-stage small strongylids (genera identified in order of frequency: Cylicostephanus, Cyathostomum, Cylicocyclus, Triodontophorus, Poteriostomum, Oesophagodontus, Cylicod...
A case of pituitary adrenocorticotropin-dependent Cushing’s syndrome in the horse. In the horse, a syndrome of hirsutism, hyperglycemia, glucosuria, polydipsia, polyuria, polyphagia, and progressive debilitation has been recognized. Most often the syndrome has been associated with adenomas of the pars intermedia of the pituitary and bilateral adrenal hyperplasia or nodular hyperplasia involving primarily the zona fasciculata. Previously, the syndrome has been ascribed to compression of the hypothalamus by an expanding but functionally inactive pituitary neoplasm. In the present case, with RIA determination of plasma ACTH concentrations, the syndrome was ascribed to pituitary...
Ten clinical cases of human infection with venezuelan equine encephalomyelitis virus, subtype I-D. The clinical and laboratory findings in ten humans infected with Venezuelan equine encephalitis virus, subtype I-D, are described in this report. Clinical and laboratory data indicate that, in contrast to equine infections, human infection with these enzootic virus strains (I-D) is similar to human infection with epizootic strains (I-ABC). In most cases there was an abrupt onset of fever, muscle pain, and vomiting. Virus was recovered from sera obtained during the first 3 days of illness. Lymphopenia occurred in all patients, and neutropenia occurred in three. No sequelae of these infections w...
Ischaemic necrosis of the navicular bone and its treatment. In a survey of 95 control horses and 16 horses with navicular disease, the incidence of erosions and discoloration of the flexor cartilage of the navicular bone was no different between the control horses and those with navicular disease. All cases of navicular disease showed thrombosis of the distal navicular nutrient arteries and this could be related to a change to a rounded or flask shape of the distal nutrient foramen of the navicular bone. Erosions and discoloration of the navicular bone are therefore of no significance in navicular disease. Previously described lines of treatment are of...
Fetal tissue transplantation for immunotherapy of combined immunodeficiency in horses. Six young horses with combined immunodeficiency were given liver cells intravenously or intraperitoneally and thymuses subcutaneously from equine fetuses ranging from 68 to 110 days of gestational age. Three of four horses given cells from fetuses over 90 days of age developed lesions compatible with graft versus host reactions. One horse given cells from an 80-day fetus developed mitogen-responsive lymphocytes, synthesized immunoglobulins of the four major equine classes, and survived to 11.5 months of age. The sixth foal receiving cells from a 68-day fetus showed no discernable effects from ...
Immunotherapy in ocular equine sarcoid. A modified Bacillus Calmette-Guerin (BCG) preparation was used successfully in the treatment of 7 cases of equine sarcoid. The BCG preparation was injected into the lesions. The longest period of remission has been 24 months, and the shortest period of remission has been 9 months, with no signs of recurrence of the tumor in any of the presented cases.
The role of allergy in chronic pulmonary disease of horses. Twenty-five horses with chronic pulmonary disease were skin tested with allergenic extracts of 24 molds, 4 thermophilic actinomyces, barn dust, hay dust, soya-bean mill dust, and grain mill dust. The results were compared with those obtained on 25 normal horses. Between the 2 groups of horses, there was a highly significant difference in positive skin test results at 30 minutes and 4 hours.
Specificity of response to viral proteins in horses infected with equine infectious anemia virus. Three structural proteins of equine infectious anemia virus were purified, labeled with 125I, and utilized in radioimmunoassays with horse sera and antisera to heterologous retroviruses. Whereas radioimmunoassay titers for the major protein, p25, were 500- to 1,000-fold higher than titers in immunodiffusion, for clinical purposes these two procedures were equivalent. Antibodies to two low-molecular-weight proteins, p12 and p10, were also found in infected horses, but with a lower frequency and lower titers. As a rule, only sera positive for p25 also contained antibody to p12 and p10. Antisera ...
Orgotein in equine navicular disease: a double blind study. Fourteen horses (7 treated with orgotein and 7 treated with a placebo) with navicular disease were studied on a double blind basis. All 14 horses had clinical and radiographic evidence of navicular disease. Orgotein and the placebo were administered by juxtabursal injection. Of the 7 orgotein-treated horses, 3 responded but none of the 7 placebo-treated horses responded. The difference was statistically significant (P less than 0.05).
Selenium and gamma-glutamyl transferase activity in the serum of thoroughbreds. Selenium and gamma-glutamyl transferase activity has been measured in the serum of clinically health thoroughbreds. The thoroughbreds, whose performance was reported to be unsatisfactory, had consistently low concentrations of selenium and high activity of gamma-glutamyl transferase in the serum when compared with those whose performance was as expected. Vitamin E levels in the serum showed no such difference. The only other biochemical and haematological abnormality was lower serum phosphate concentrations in the unsatisfactory group. These results suggest that low concentrations of selenium ...
Stability of the lyophilized F(ab’)2 fragments of horse tetanus antibodies isolated by affinity chromatography. F(ab')2 fragments of horse tetanus antibodies were obtained from horse hyperimmune sera after peptic digestion. The digest was passed through a column of tetanus toxoid coupled with Sepharose 4B, F(ab')2 fragments were eluted with a solution of 5 mM HCl in 150 mM NaCl and the eluates were concentrated by ultrafiltration and lyophilized. Glycine and human serum albumin were used as stabilizing agents. Polyacrylamide gel electrophoretic mobility and molecular weight of the fragments remained unchanged after lyophilization. Freeze-dried preparations stored two months at 56 degrees C showed only a...
