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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Blood glutathione peroxidase activity in horses in relation to muscular dystrophy and selenium nutrition. The activity of glutathione peroxidase, a selenium containing enzyme, was measured in the blood of horses to determine its usefulness as an indicator of selenium status. In 15 horses the enzyme activity was positively related to the blood selenium concentration (P less than .001, r-0.98) over the range of enzyme activities of 8.2 to 140 units (mumoles NADP-oxidised/min/gHb) and selenium concentrations of 0.24 to 2.74 mumol/l. In a group of 8 horses which 2 foals had died with lesions of muscular dystrophy the enzyme activity increased from a mean of 11.8 units before treatment with selenium to...
Evaluation of inferior check ligament desmotomy for treatment of acquired flexor tendon contracture in the horse. The usefulness of inferior check ligament desmotomy as a treatment for acquired tendon contracture in horses was evaluated in 13 cases of deep digital flexor (DDF) contracture and in 3 cases of combined superficial digital flexor (SDF) and DDF contracture. In 8 of 9 cases of DDF contracture in which the dorsal surface of the hoof had not passed beyond being vertical to the ground, the surgical procedure was successful in returning the limb to a normal position and function. Compared with DDF tenotomy, inferior check ligament desmotomy was a superior treatment technique because of decreased pos...
Mixed lymphocyte culture responses in combined immunodeficiency of horses. Combined immunodeficiency in horses is a genetic disorder in which there is a defect in the production of committed B and T lymphocytes. In this study, peripheral blood mononuclear leukocytes from foals with combined immunodeficiency were examined for their capacity to stimulate and respond in one-way mixed lymphocyte cultures. Irradiated cells from combined immunodeficient foals were uniformly capable of stimulating cells from unrelated horses. However, none were able to respond to allogeneic stimulation. Examination of cells from known carrier horses revealed no difference in capacity to sti...
Repair of physeal fractures of the tuber olecranon in the horse, using a tension band method. Physeal fractures of the tuber olecranon of 4 horses were treated, using the tension band method of compression fracture repair. A cortical bone screw and Steinmann pin were placed through the proximal fragment into the distal parent bone parallel to the palmar border of the olecranon. The tension band was placed dorsal to the Steinmann pin and anchored in a hole through the shaft of the ulna 10 cm distal to the tuber olecranon. Of the 4 foals, 2 became pasture sound, 1 is now being worked under saddle, and the 4th showed no signs of lameness 5 months after surgery.
Immunocytochemical demonstration of calcitonin-containing C-cells in the thyroid glands of different mammals. In the thyroid glands of the horse, pig, deer, mole, and rat, C-cells could be demonstrated by means of the immunocytochemical PAP-technique using rabbit antisera against human calcitonin. Only in ruminants, the cross-reaction between the intracellularly stored antigen and the antibodies used appeared to be incomplete.
Synthetic antigens. Horse “natural” antibodies against interpolymer of styrene and maleic acid (PSM). Properties of horse natural anti-PSM antibodies are described. The antibodies were of IgG class. Electrostatic forces were mainly involved in reaction of PSM with horse antibodies. The reaction was inhibited by low molecular compounds resembling structural unit of PSM. Studies of difference spectra and ORD and CD spectra showed no major conformational changes in horse antibodies after reaction with PSM.
[Blood serum biochemistry of ponies (author’s transl)]. A wide blood serum biochemical profile, concerning especially blood lipids has been performed in 31 apparently healthy Shetland and Potiock ponies. These blood standard values will be useful for studies on ponies' hyperlipemia.
A new allele in the prealbumin system of horse serum markers. A family study of an index case in the Arabian breed of horses demonstrated the presence of a new allele in the prealbumin (Pr) system of electrophoretically determined markers in horse serum which, when homozygous, results in the absence of any recognizable zones in the Pr region. The symbol PrO is proposed for this allele which has an estimated frequency in Arabian horses of 0.09.
Problems in pleasure horse practice. Various common problems encountered daily pleasure horse practice will be discussed covering diagnosis, treatment and prevention.
Studies on the faecal egg output of horses after treatment with fenbendazole. Examination of faecal egg counts in horses and ponies has shown that after treatment with fenbendazole at dose levels of 7.5, 45 and 60 mg/kg, faeces remained free from strongyle eggs for periods of 6 to 18 weeks. The significance of these results is discussed in relation to routine anthelmintic treatment of horses. In particular, the activity of fenbendazole against mucosal stages of strongyle parasites allows for treatment to be recommended at less frequent intervals than when using other anthelmintics.
Chronic obstructive pulmonary disease (COPD): identification of affected horses. Mean normal values for PaO, and max A Ppl for horses were determined. Using 2 standard deviations below (Pa0,) and above (max A Ppl) the mean normal values as a guide, horses affected with COPD were satisfactorily distinguished from other horses in a series of 100 animals. The frequency of occurrence of 20 different clinical parameters in affected, not affected and possibly affected horses was examined statistically. Poor work performance and a history of previous febrile illness occurred more often in COPD horses than in others. The presence of a chronic cough, dyspnoea, double expiratory eff...
[Hippotherapy in multiple sclerosis (author’s transl)]. No abstract available
[Immunodiffusion serologic study of equine infectious anemia in the Province of Buenos Aires, Argentina]. Twenty seven per cent of 238 serum samples obtained from horses with clinical diagnosis were positive for the immunodifusion test, while 17% of the 452 sera obtained from asintomatic horses were positive. Twenty one per cent of the 870 sera studied were positive.
Artifact production with micromanometers used to record intracardiac pressure and sound. In horses experimental right and left heart catheterization using a catheter with two microtransducers 9 cm apart, usually in a transvalval position produced pressure and sound artifacts that confounded the diagnosis. Most were probably due to malpositioning resulting in movement through a valve during recording or impingement on the valve cusps or the chordae tendineae or lodgement in the apex of the heart. The recognition of these artifacts is particularly important in studies of large animals in which catheter siting cannot be monitored by radiography.
Isoelectric focusing of horse serum esterase isozymes and detection of new phenotypes. A new method for separating the isozymes of horse serum esterase is described. The improved resolution has enabled us to detect several previously undescribed phenotypes. This method has also been used to detect two different apparently 'silent' alleles.
Diagnosis of equine neurologic problems. This is a review of the more common diseases of the spinal cord and various areas of the brain of horses. The results of a two and one-half year study of spinal cord disease are emphasized. After a description of the lesion the salient clinical signs are described and the features that differentiate them from other similar diseases. In the seminar, films of case and slides of lesions will be shown to document these diseases.
