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Topic:Disease Treatment
Disease treatment in horses encompasses a range of medical interventions and management strategies aimed at addressing various health conditions affecting equine species. These treatments can include pharmacological approaches, such as the administration of antibiotics, anti-inflammatory drugs, and antiparasitic medications, as well as non-pharmacological methods like physical therapy, dietary adjustments, and surgical procedures. The selection of appropriate treatments depends on the specific disease, its severity, and the individual needs of the horse. This topic brings together peer-reviewed research studies and scholarly articles that explore the efficacy, safety, and advancements in therapeutic options for equine diseases, providing insights into best practices and emerging trends in equine veterinary medicine.
Ovarian disorders: clinical and morphological observations in 30 mares. A five year prospective study of equine ovarian problems requiring surgical correction was undertaken at the Ontario Veterinary College. Thirty mares were studied, of which 14 had granulosa cell tumors, six were with anovulatory persistent follicular "structures", five had ovarian hemotoma, two presented ovarian hypoplasia and one each of ovarian dysgerminoma, teratoma and abscessation. The clinical signs manifested by the affected animals were varied. The affected ovaries were removed via flank or midline laparotomy or through colpotomy. Their morphology was studied and representative portion...
The interaction of Corynebacterium equi and equine alveolar macrophages in vitro. The in-vitro interaction of Corynebacterium equi and foal alveolar macrophages was examined qualitatively and quantitatively using cells collected by sequential bronchoalveolar lavage at 2-week intervals from birth until 14 weeks of age. Total and differential counts were performed on the recovered cells. Macrophages were identified using the non-specific esterase strain. Cultures of the alveolar macrophages were challenged with C. equi suspensions and the process and extent of ingestion was examined by light and electron microscopy. Few macrophages were recovered from the lungs of foals less ...
[Effect of low pH values on the infectivity and neuraminidase activity of human and animal strains of influenza virus type A]. The influence of acidic pH on the infectivity and neuraminidase activity of human, equine and avian type A influenza virus strains has been studied. Following exposure to pH 3 human and equine strains lost their infectivity completely, whereas all investigated strains of the subtypes Hav6N2 and Hav7Neq2 retained a certain amount of infectivity. In contrast to human and equine strains the avian strains retained also 38% of their original neuraminidase activity after acidic treatment. Partial retention of infectivity and the relative stability of the neuraminidase following exposure to acidic pH...
Immunodeficiency disease in animals. Significant contributions to understanding the role of lymphocyte subpopulations in the immune response and to the characterization of immunodeficiencies in children have been achieved through study of animal models of immunodeficiency. Additional contributions can be made in two important areas. One is through identification of relevant, naturally-occurring models of adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. The second, and potentially more important contribution, would be the identification of the metabolic basis for existing immune deficiencies. The nece...
[Sensitivity and fidelity of the rabies laboratory diagnosis]. The author describes a method for evaluating the minimal number of diagnosis failures for each animal species (this diagnosis uses the Fluorescent Rabies Antibodies Test and mouse inoculation simultaneously). The percentage of well diagnosed rabid animals on total rabid ones is called sensibility of the diagnosis: it varies according to the species of animal examined: from 99.98% for the fox, to 98.61% for the horse. The percentage of errored negative diagnosis on total negative diagnosis is called infidelity of negative responses: it varies for each species according to the sensibility of the...
Control of nutritional secondary hyperparathyroidism in grazing horses with calcium plus phosphorus supplementation. A supplement system for the control of equine nutritional secondary hyperparathyroidism (NSH) was evaluated on 4 farms in the Arcadia Valley of the Queensland brigalow region. Thirty-three local stock horses (of which 13 had clinical NSH and 7 were recent introductions) were grazed on buffel grass (Cenchrus ciliaris) for the 6 months from September 1979 to February 1980. Each horse was fed 1.0 kg of a mixture of ground limestone plus dicalcium phosphate (1:2) in 1.5 kg molasses each week. The pasture was hazardous during this time (total oxalate content above 0.5% and calcium: oxalate ratio be...
Bacteriologic examination of equine fecal flora as a diagnostic tool for equine intestinal clostridiosis. The fecal flora of 56 clinically healthy and 23 sick horses were examined bacteriologically for counts of Clostridium perfringens, molds, coliforms, alpha- and beta-hemolytic streptococci, and microbes belonging to genus Bacillus, as well as for the presence of Salmonella spp. Of the healthy horses, 85.7% had a C perfringens count less than 10(1) colony-forming units/g of feces. Of the healthy horses, lowest counts were found in race-horses. Of the sick horses, equine intestinal clostridiosis was diagnosed in 2 horses with large C perfringens counts (10(4) to 10(7) colony-forming units/g) and ...
Mechanisms of infection in the respiratory tract. Related to its potential vulnerability the respiratory tract has a very complex and effective defence apparatus. The interaction between these defence mechanisms and certain characteristics of aetiological agents results in a pattern in which initial infections by these agents tend to occur at specific sites in the tract. Infections in which the primary portal of entry is in the upper respiratory tract include Bordetella bronchiseptica and Haemophilus spp in pigs; Pasteurella spp in cattle, sheep, pigs; Mycoplasma spp in cattle, sheep, pigs and poultry; equine herpesvirus 1 in horses; infectio...
Diagnostic methods in infectious respiratory disease. For laboratory diagnosis of respiratory disease it is of overwhelming importance that the specimens taken are adequate, taken from the correct site and at the correct time. The lower regions of the respiratory tract are particularly difficult to sample but are more likely to yield the causative agent of a pneumonia. Infections involving the upper respiratory tract are much easier to sample and appropriate aspiration apparatus can be used. Consideration must be given to the timing of sample collection in relation to the life cycle of the causative micro-organism. Sampling of several animals is ...
Nasal aspergillosis in three horses. Three horses were referred for investigation of a unilateral foul smelling scanty nasal discharge, complicated in one case by intermittent epistaxis. Thick purulent material or a mycotic plaque was identified by an endoscopic examination of the middle meatus but in two horses this had to be repeated under general anaesthesia before the abnormalities were detected. Aspergillus fumigatus was cultured from all three cases and septate hyphae were identified on smears from lesions. Histological examination of the lesion in one case revealed a fungal mycelium. Topical treatment with natamycin soluti...
Treatment of hygromata in horses. A surgical technique of open drainage, using penrose drains and pressure bandages, was used for the treatment of hygromata in four horses. In 3 cases with hygroma of the carpus, one with a secondary infection, there was complete resolution of the condition whereas in the one case with hygroma of the elbow resolution was more protracted because of difficulties in bandaging. The cosmetic and functional results after operation were most satisfactory.
Restoration of reproductive capacity of stallions after suppression with exogenous testosterone. Twelve stallions that had been given 0, 50 or 200 micrograms testosterone propionate (TP)/kg body weight every other day for 88 days were examined for the effects of androgen withdrawal on spermatozoal production, seminal quality and libido. Although the lower dosage did not affect most of the traits studied, the higher dosage severely reduced scrotal width, spermatozoal production, the number of sperm per ejaculate, the percentage of progressively motile spermatozoa and the percentage of normal spermatozoa. These adverse effects were found to be largely reversible. By 90 days after the cessat...
Efficacy of ivermectin against cutaneous Draschia and Habronema infection (summer sores) in horses. Thirty-one horses with naturally occurring summer sores were given a single IM injection of 0.2 mg of ivermectin (22,23-dihydroavermectin B1)/kg during the summer of 1980. Larvae of Draschia and/or Habronema spp were recovered from biopsy samples taken from 21 of 25 horses (84%) on the day of anthelmintic treatment. There was a marked clinical improvement in 26 horses (84%) 7 days after ivermectin was given. The typical summer sore was replaced by healthy pink granulation tissue at 7 days and this healed after 1 to 5 weeks. Biopsy samples were taken from 21 of these horses 1 to 6 weeks after t...
Malignant hyperthermia in a halothane-anesthetized horse. Malignant hyperthermia developed in a 4-year-old Thoroughbred horse following 3 hours and 15 minutes of halothane anesthesia, with supplementary succinylcholine. Clinical signs included fever, sweating, hyperventilation, tachycardia, and decreased blood pressure followed by a rapid increase in blood pressure. Biochemical aberrations included hypocalcemia, hyperkalemia, hyperphosphatemia, myoglobinuria, and high creatine phosphokinase and ornithine carbamyl transferase activities. Treatment consisted initially of surface cooling with cold water, alcohol and ice, IV administration of cooled bala...
Anthelmintic activity of paste and drench formulations of oxfendazole in horses. Oxfendazole was administered in paste or drench formulations to groups of five horses carrying naturally acquired worm burdens. At a dose rate of 10 mg/kg the efficacy of either formulation appeared similar. One hundred per cent of the adult populations of the following genera was removed: Parascaris, Oxyuris, Strongylus (S edentatus, S vulgaris), Triodontophorus and Trichostrongylus axei. Efficacy against adult small strongyles, adult Habronema microstoma and immature Oxyuris equi was in the region of 96 to 99 per cent. The level of efficacy against immature small strongyles was at least 74 t...
Field and laboratory studies of equine influenza viruses isolated in 1979. Experimental ponies developed signs of disease four days after the intranasal instillation of A/England 1/79 equine influenza virus and virus was recovered from the nasopharynx from the second to the ninth day. No significant antigenic difference was found between the virus and the prototype A/Miami 1/63 virus, using post infection ferret and chicken sera and post vaccination pony sera. No antigenic differences were found between four viruses isolated between January and July 1979, although some differences were found in their ability to detect haemagglutination inhibiting antibody in convales...
Chronic respiratory disease in a horse infected with Dictyocaulus arnfieldi. A 6-year-old Thoroughbred gelding was examined because of respiratory disease that developed after it was placed on pasture occupied by a donkey. Clinical signs in the gelding included a harsh, dry paroxysmal cough and increased expiratory effort. Eosinophils were seen in smears of mucus aspirated from the trachea and the bronchi. Immature, 5th-stage Dictyocaulus arnfieldi was identified in the tracheal mucus. The cough and other clinical signs were not diminished by corticosteroid therapy or by the administration of bronchodilators. Treatment with 10-fold therapeutic dosages of thiabendazole ...
