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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Diagnosis of emerging ehrlichial diseases of dogs, horses, and humans.
Journal of veterinary internal medicine    June 1, 2000   Volume 14, Issue 3 250-251 doi: 10.1111/j.1939-1676.2000.tb01162.x
Rikihisa Y.No abstract available
Chronic idiopathic inflammatory bowel diseases of the horse.
Journal of veterinary internal medicine    June 1, 2000   Volume 14, Issue 3 258-265 doi: 10.1892/0891-6640(2000)0142.3.co;2
Schumacher J, Edwards JF, Cohen ND.A review of reported cases of inflammatory bowel diseases (IBDs) of horses for which no etiology was identified included cases of granulomatous enteritis (GE), multisystemic eosinophilic epitheliotropic disease (MEED), lymphocytic-plasmacytic enterocolitis (LPE), and idiopathic eosinophilic enterocolitis (EC). The terms EC and MEED were both used to describe a disease in horses characterized by infiltration of intestine and extraintestinal tissues with eosinophils. We use EC to describe IBD characterized by only intestinal infiltration by eosinophils. Horses with GE, MEED, or LPE are usually e...
Detection and quantitation of Ehrlichia risticii genomic DNA in infected horses and snails by real-time PCR.
Veterinary parasitology    June 1, 2000   Volume 90, Issue 1-2 129-135 doi: 10.1016/s0304-4017(00)00227-2
Pusterla N, Leutenegger CM, Sigrist B, Chae JS, Lutz H, Madigan JE.A real-time quantitative PCR using the TaqMan fluorogenic detection system (TaqMan PCR) was established for identification of Ehrlichia risticii, the agent of Potomac horse fever (PHF). The TaqMan PCR identified an 85 base pair section of the 16S rRNA gene by use of a specific fluorogenic probe and two primers. This technique was specific for eight tested E. risticii strains. The TaqMan system identified 10 copies of a cloned section of the 16S rRNA gene of E. risticii. The sensitivity and specificity of the TaqMan PCR were similar to those of conventional nested PCR. The TaqMan PCR was evalua...
Ehrlichia equi infection of horses from Minnesota and Wisconsin: detection of seroconversion and acute disease investigation.
Journal of veterinary internal medicine    June 1, 2000   Volume 14, Issue 3 252-257 doi: 10.1892/0891-6640(2000)014<0252:eiohfm>2.3.co;2
Bullock PM, Ames TR, Robinson RA, Greig B, Mellencamp MA, Dumler JS.Equine granulocytic ehrlichiosis (EGE) is caused by infection with Ehrlichia equi. EGE has been reported primarily in northern California, where E equi is transmitted by the tick Ixodes pacificus. Reports of EGE and the emergence of human granulocytic ehrlichia in Minnesota prompted a seroprevalence study of E equi in horses of Minnesota and Wisconsin. Tick (Ixodes scapularis) endemic areas of Minnesota and Wisconsin were compared to nonendemic regions of Minnesota. Indirect fluorescent antibody was used to detect the presence of serum antibodies to E equi. Serum samples from healthy horses, 3...
Cross reactivity between human erythropoietin antibody and horse erythropoietin.
Electrophoresis    June 1, 2000   Volume 21, Issue 8 1454-1457 doi: 10.1002/(SICI)1522-2683(20000501)21:83.0.CO;2-G
Kearns CF, Lenhart JA, McKeever KH.Erythropoietin (EPO) is the primary hormone of erythropoiesis. Administration of recombinant human erythropoietin (rhuEPO) to improve racing performance in the horse represents a new form of blood doping, which has been associated with increased mortality. While immunoassay kits have become plentiful, very few commercial hormone assays are made specifically for equine research. There is a strong degree of sequence homology reported for EPO among species, which has allowed antibodies designed for human EPO research to be used to determine EPO concentration in other species. The objective of the...
Effect of PGF2alpha and 13,14-dihydro-15-keto-PGF2alpha (PGFM) on corpora luteal function in nonpregnant mares.
Theriogenology    June 1, 2000   Volume 53, Issue 6 1263-1271 doi: 10.1016/S0093-691X(00)00270-3
Vanderwall DK, Betschart RW, Squires EL.The objective of this study was to determine if the primary circulating metabolite of PGF2alpha, 13,14-dihydro-15-keto-PGF2alpha (PGFM), is biologically active and would induce luteolysis in nonpregnant mares. On Day 9 after ovulation, mares (n = 7/group) were randomly assigned to receive: 1) saline control, 2) 10 mg PGF2alpha or 3) 10 mg PGFM in 5 mL 0.9% sterile saline i.m. On Days 0 through 16, blood was collected for progesterone analysis. In addition, blood was collected immediately prior to treatment, hourly for 6 h, and then at 12 and 24 h after treatment for progesterone and PGFM analy...
Laparoscopic intra-abdominal ligation of the testicular artery following castration in a horse.
Journal of the American Veterinary Medical Association    May 29, 2000   Volume 216, Issue 10 1596-1569 doi: 10.2460/javma.2000.216.1596
Trumble TN, Ingle-Fehr J, Hendrickson DA.A 364-kg (800-lb) 1-year-old mixed-breed horse was admitted for treatment of uncontrolled bleeding after castration. Multiple attempts to ligate the testicular artery through the scrotal incisions prior to referral had been unsuccessful. Because of the owner's concerns about cost, an attempt was made to control the bleeding by applying pressure to the inguinal region and administering formalin IV. However, hemorrhage continued. A decision was made to use laparoscopy to ligate the testicular artery. The horse was anesthetized and positioned in dorsal recumbency, and a routine ventral laparoscop...
Spinal ataxia in a horse caused by an arachnoid diverticulum (cyst). Allison N, Moeller RB.No abstract available
Extramedullary plasmacytoma in a horse with ptyalism and dysphagia. McConkey S, López A, Pringle J.A Clydesdale mare was examined for weight loss, inappetence, ptyalism, and dysphagia. The main abnormality revealed by serum biochemistry was a marked hyperglobulinemia, and protein electrophoresis revealed a monoclonal gammopathy in the gamma region. The urine was positive for Bence Jones proteins. These findings suggested a plasma cell tumor. The neoplasm could not be located with extensive antemortem examination. At postmortem, neoplastic cells morphologically compatible with plasma cells and positive for equine IgG with imunoperoxidase staining infiltrated the pericardium, mediastinal stro...
Papillomatous pastern dermatitis with spirochetes and Pelodera strongyloides in a Tennessee Walking Horse. Rashmir-Raven AM, Black SS, Rickard LG, Akin M.Papillomatous digital dermatitis is a common disease in cattle. The pastern dermatitis observed in a horse shared many of the gross characteristics of papillomatous digital dermatitis in cattle. Lesions included a mixture of proliferative and erosive changes, with a verrucose appearance in some areas. Microscopic similarities included pseudoepitheliomatous and papillomatous epidermal hyperplasia with hyperkeratosis, spongiosis of the epidermis, and intraepidermal spirochetes. The horse was also concurrently infected with Pelodera strongyloides. Papillomatous digital dermatitis in cattle is ass...
Toxigenic Corynebacterium diphtheriae associated with an equine wound infection. Henricson B, Segarra M, Garvin J, Burns J, Jenkins S, Kim C, Popovic T, Golaz A, Akey B.No abstract available
Serum parathyroid hormone and calcitonin levels in racehorses with fracture.
The Journal of veterinary medical science    May 24, 2000   Volume 62, Issue 4 361-365 doi: 10.1292/jvms.62.361
Chiba S, Kanematsu S, Murakami K, Satoh A, Asahina M, Numakunai S, Goryo M, Ohshima K, Okada K.Serum parathyroid hormone (PTH) and calcitonin (CT) levels in fractured racehorses were measured by radioimmunoassay. Racehorses with fracture of large bone such as the radius, third metacarpus, third carpus, digital bone or tibia, showed normal PTH level and elevated CT level in the serum. Serum PTH level was slightly higher in racehorses with sesamoid bone fracture compared to that of healthy racehorses, but not statistically significant. Moreover, serum CT level of racehorses with sesamoid bone fracture was significantly higher than that of healthy racehorses. Racehorses with sesamoid bone ...
Ultrastructure of the horse tongue: further observations on the lingual integumentary architecture.
Anatomia, histologia, embryologia    May 23, 2000   Volume 29, Issue 1 37-43 doi: 10.1046/j.1439-0264.2000.00232.x
Pfeiffer CJ, Levin M, Lopes MA.This investigation examined primarily epidermal specializations of the adult horse tongue by light, scanning and transmission electron microscopy. Samples were collected from seven regions of the normal tongue of various breeds of horse. The filiform papillae, present on the dorsal and lateral aspects but not the ventral aspect of the tongue, were short, slender and finger-like structures with variable-shaped terminae. The epidermal thickness and height of dermal ridges were reduced on fungiform and vallate papillae, but tissue architecture and keratinocyte ultrastructure of most of the lingua...
Ileal muscular hypertrophy and rupture in a pony three years after surgery for ileocaecal intussusception.
The Veterinary record    May 20, 2000   Volume 146, Issue 16 472-473 doi: 10.1136/vr.146.16.472
Mair TS, Lucke VM.No abstract available
Horse conceptuses secrete insulin-like growth factor-binding protein 3.
Biology of reproduction    May 20, 2000   Volume 62, Issue 6 1804-1811 doi: 10.1095/biolreprod62.6.1804
Herrler A, Pell JM, Allen WR, Beier HM, Stewart F.Insulin-like growth factor-I (IGF-I) promotes early embryonic development in several species. In the rabbit, IGF-I binds to the embryonic coats from Day 3 of development onward by a 38-kDa protein that is probably insulin-like growth factor-binding protein 3 (IGFBP3). In the present study, ligand, Western, and Northern blot analyses were used to demonstrate the presence of IGF-I-binding activity, several immunoreactive IGFBP3 proteins, and IGFBP3 mRNA in horse conceptuses with particularly large amounts of immunoreactive IGFBP3 in the conceptus capsule. In addition, immunoprecipitation of radi...
Stallion epididymal fluid proteome: qualitative and quantitative characterization; secretion and dynamic changes of major proteins.
Biology of reproduction    May 20, 2000   Volume 62, Issue 6 1790-1803 doi: 10.1095/biolreprod62.6.1790
Fouchécourt S, Métayer S, Locatelli A, Dacheux F, Dacheux JL.Proteins present in and secreted into the lumen of various regions of the stallion epididymis were characterized qualitatively and quantitatively by two-dimensional electrophoresis. Using this proteomic approach, 201 proteins were found in the lumen and 117 were found that were secreted by the epithelium in various parts of the organ. Eighteen proteins made up 92.6% of the total epididymal secretory activity, lactoferrin (41.2%) and clusterin (24.8%) being the most abundant. Procathepsin D, HE1/CTP (cholesterol transfer protein), GPX (glutathione peroxidase), beta-N-acetyl-hexosaminidase, and ...
Tansy ragwort poisoning in a horse in southern Ontario.
The Canadian veterinary journal = La revue veterinaire canadienne    May 19, 2000   Volume 41, Issue 5 409-410 
de Lanux-Van Gorder V.Bizarre behavior, apparent lameness, and colic were noticed in 1 of 3 horses on a pasture overgrown by weeds during a drought. Liver failure and hepatoencephalopathy were diagnosed, caused by pyrrolizidine alkaloid toxicosis associated with consumption of tansy ragwort. The horse made a full recovery when removed from the pasture.
Ligature slippage during standing laparoscopic ovariectomy in a mare.
The Canadian veterinary journal = La revue veterinaire canadienne    May 19, 2000   Volume 41, Issue 5 395-397 
Rodgerson DH, Hanson RR.Suture ligature failure is a potential complication during laparoscopic ovariectomy techniques utilizing ligatures as a means of hemostasis. This complication in the standing mare and the successful use of laparoscopic electrosurgical instrumentation as the sole means of providing hemostasis to the mesovarium of a mare are described.
Equine phacoclastic uveitis: the clinical manifestations, light microscopic findings, and therapy of 7 cases.
The Canadian veterinary journal = La revue veterinaire canadienne    May 19, 2000   Volume 41, Issue 5 376-382 
Grahn BH, Cullen CL.This retrospective clinical study describes the clinical manifestations, light microscopic findings, and diagnosis and treatment of acute and chronic lens rupture in the horse. Rupture of the lens capsule in the horse usually results in a chronic, blinding inflammation (phacoclastic uveitis) unless prompt surgical and medical therapies are implemented. The clinical manifestations of acute lens capsule rupture included: cataract; intralenticular displacement of iridal pigment; lens cortical fragments attached to the perforated lens capsule, iris, and corneal endothelium; miosis; aqueous flare; ...
[Laparoscopic ovariectomy in the standing mare].
Tijdschrift voor diergeneeskunde    May 17, 2000   Volume 125, Issue 8 248-251 
ter Braake F, Hesselink JW, Jonker FH.An eleven year old warmblood mare was referred to Dierenkliniek Emmeloord because of recurrent cyclic behavioral problems. A standing bilateral laparoscopic ovariectomy was performed. Due to this minimal invasive technique a quick return to training was possible.
Pyrrolizidine alkaloid poisoning of horses grazing a native heliotrope (Heliotropium ovalifolium).
Australian veterinary journal    May 17, 2000   Volume 77, Issue 6 401-402 doi: 10.1111/j.1751-0813.1999.tb10318.x
Creeper JH, Mitchell AA, Jubb TF, Colegate SM.No abstract available
Treatment of progressive ethmoidal haematoma using intralesional injections of formalin in three horses.
Australian veterinary journal    May 17, 2000   Volume 77, Issue 6 371-373 doi: 10.1111/j.1751-0813.1999.tb10306.x
Marriott MR, Dart AJ, Hodgson DR.Three Thoroughbred horses with unilateral progressive ethmoid haematomas were treated using intralesional injections of 10% formalin (4% formaldehyde solution). Injections were performed in the standing sedated horse through the nasal passages under endoscopic guidance and, when the ethmoid haematoma involved the paranasal sinuses, through holes trephined into the affected sinus. Regression of the lesions occurred in all cases after repeated injections. This technique appears to be a safe and effective treatment for progressive ethmoid haematomas in the horse.
Autologous morsellised bone grafting restores uncontained femoral bone defects in knee arthroplasty. An in vivo study in horses.
The Journal of bone and joint surgery. British volume    May 17, 2000   Volume 82, Issue 3 436-444 doi: 10.1302/0301-620x.82b3.9491
van Loon CJ, de Waal Malefijt MC, Buma P, Stolk T, Verdonschot N, Tromp AM, Huiskes R, Barneveld A.The properties of impacted morsellised bone graft (MBG) in revision total knee arthroplasty (TKA) were studied in 12 horses. The left hind metatarsophalangeal joint was replaced by a human TKA. The horses were then randomly divided into graft and control groups. In the graft group, a unicondylar, lateral uncontained defect was created in the third metatarsal bone and reconstructed using autologous MBG before cementing the TKA. In the control group, a cemented TKA was implanted without the bone resection and grafting procedure. After four to eight months, the animals were killed and a biomechan...
Cerebello-olivary and lateral (accessory) cuneate degeneration in a juvenile American Miniature horse.
Veterinary pathology    May 16, 2000   Volume 37, Issue 3 271-274 doi: 10.1354/vp.37-3-271
Fox J, Duncan R, Friday P, Klein B, Scarratt W.A 12-month-old American Miniature horse colt was presented to the Virginia Tech Veterinary Teaching Hospital with a 7-month history of progressive ataxia. Physical examination revealed a head intention tremor, base-wide stance, and ataxia. Necropsy findings were confined to the brain. There were bilateral areas of liquefactive necrosis and cavitation corresponding to the dorsal accessory olivary and lateral (accessory) cuneate nuclei. Cerebellar folia of the dorsal vermis were thin. Microscopically, the cerebellar cortex was characterized by patchy areas of Purkinje cell loss with associated v...
Lymphangiosarcoma in a horse.
Journal of comparative pathology    May 12, 2000   Volume 122, Issue 4 312-316 doi: 10.1053/jcpa.1999.0374
IJzer J, van den Ingh TS.A 15-year-old Dutch Warmblood mare presented with respiratory distress and anorexia. Clinical examination revealed liquothorax and an abdominal mass. At necropsy, an infiltrating tumour was found in the visceral trunk, continuing through the diaphragm into the mediastinum. Histopathology, immunohistochemistry and electronmicroscopy showed empty channels lined by atypical endothelial cells, and neoplastic cells in a disorganized pattern, consistent with the diagnosis of a lymphangiosarcoma.
Virulence of the V592 isolate of equid herpesvirus-1 in ponies.
Journal of comparative pathology    May 12, 2000   Volume 122, Issue 4 288-297 doi: 10.1053/jcpa.1999.0373
Smith KC, Whitwell KE, Mumford JA, Hannant D, Blunden AS, Tearle JP.The V592 strain of equid herpesvirus-1 (EHV-1), which was originally isolated from a fetus during an abortion epizootic, has proved to be of low virulence in infection studies. Five Welsh Mountain pony mares and one foal were challenged intranasally or by aerosol with this isolate, and monitored clinically and virologically. All six animals shed virus in nasopharyngeal mucus, and viraemia was recorded from day 7 post-infection (PI). Pathological investigations revealed mild rhinitis and bronchiolitis in the mares, with viral antigen expression in degenerating epithelial cells of the nasal muco...
Direct MS-MS identification of isoxsuprine-glucuronide in post-administration equine urine. Bosken JM, Lehner AF, Hunsucker A, Harkins JD, Woods WE, Karpiesiuk W, Carter WG, Boyles J, Fisher M, Tobin T.Isoxsuprine is routinely recovered from enzymatically-hydrolyzed, post-administration urine samples as parent isoxsuprine in equine forensic science. However, the specific identity of the material in horse urine from which isoxsuprine is recovered has never been established, although it has long been assumed to be a glucuronide conjugate (or conjugates) of isoxsuprine. Using ESI/MS/MS positive mode as an analytical tool, urine samples collected 4-8 h after isoxsuprine administration yielded a major peak at m/z 554 that was absent from control samples and resisted fragmentation to daughter ions...
Effects of phenylbutazone on bone activity and formation in horses.
American journal of veterinary research    May 10, 2000   Volume 61, Issue 5 537-543 doi: 10.2460/ajvr.2000.61.537
Rohde C, Anderson DE, Bertone AL, Weisbrode SE.To determine the effects of phenylbutazone (PBZ) on bone activity and bone formation in horses. Methods: 12 healthy 1- to 2-year-old horses. Methods: Biopsy was performed to obtain unicortical bone specimens from 1 tibia on day 0 and from the contralateral tibia on day 14. Fluorochromic markers were administered IV 2 days prior to and on days 0, 10, 15, and 25 after biopsy was performed. Six horses received PBZ (4.4 mg/kg of body weight, PO, q 12 h) and 6 horses were used as controls. All horses were euthanatized on day 30 and tissues from biopsy sites, with adjacent cortical bone, were collec...
The effect of flat horseshoes, raised heels and lowered heels on the biomechanics of the equine hoof assessed by finite element analysis (FEA).
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine    May 10, 2000   Volume 47, Issue 2 73-82 doi: 10.1046/j.1439-0442.2000.00263.x
Hinterhofer C, Stanek C, Haider H.The biomechanical effects of lowering and raising the heels were studied using a finite element (FE) computer model of the equine hoof capsule consisting of 18,635 finite elements. A static load of 3000 N was distributed to nodes of the inner hoof wall (80%) according to the suspension of the coffin bone, 20% loaded sole and frog. When loaded the FE hoof capsules showed the following deformations: the proximal dorsal wall moves back, the quarters flare to the side and sole and frog perform a downward movement. Stresses are high in the material surrounding the quarter nails, in the heels and in...
Effects of polysulfated glycosaminoglycan and hyaluronan on prostaglandin E2 production by cultured equine synoviocytes.
American journal of veterinary research    May 10, 2000   Volume 61, Issue 5 499-505 doi: 10.2460/ajvr.2000.61.499
Frean SP, Lees P.To investigate effects of the anti-arthritic agents hyaluronan and polysulfated glycosaminoglycan (PSGAG) on inflammatory metabolism in cultured equine synoviocytes. Methods: Synoviocytes cultured from samples obtained from the metacarpophalangeal joints of 4 horses. Methods: Equine synoviocytes were grown in monolayer culture. Synoviocytes were stimulated with lipopolysaccharide (LPS) and simultaneously treated with various concentrations of hyaluronan or PSGAG for 48 hours. Three hyaluronan preparations were compared. Prostaglandin E2 (PGE2) concentrations in culture medium were measured, us...