Genetics in horses encompasses the study of hereditary traits and the genetic makeup that influences various characteristics and health conditions in equine populations. This field involves the analysis of genes and their functions, inheritance patterns, and the impact of genetic variations on traits such as coat color, performance ability, and susceptibility to diseases. Research in equine genetics employs techniques such as genome mapping, sequencing, and genetic testing to identify specific genes and mutations associated with these traits. This page gathers peer-reviewed research studies and scholarly articles that explore the genetic basis of equine traits, the methodologies used in genetic research, and the implications for breeding, health management, and conservation of horse breeds.
Lowe JE, Baldwin BH, Foote RH, Hillman RB, Kallfelz FA.Surgical thyroidectomies (Thx) were per-formed in 6 yearling grade horse colts, (3 males, 3 females). Five control colts (3 males, 2 females) were included and comparative studies were carried out for 67 weeks. The comparative measurements included rectal temperature, heart rate, feed consumption, packed cell volume, serum cholesterol, serum calcium, serum phosphorus, serum TO height, heart girth, body weight, epiphyseal plate closure and tooth eruption times. A thyroprotein supplement was fed to the Thx males during weeks 46 to 53. The Thx animals failed to grow in height, were sensi-tive to ...
van der Linden LS, Bustamante-Filho IC, Souza APB, Lopes TN, da Silva AFT, Tomé LM, Timmers LFMS, Dos Santos SI, Neves AP.The protein disulphide isomerase A1 (PDIA1) is an important chaperone involved in protein quality control and redox regulation. Also, the ability of PDIA1 to bind to oestrogens suggests that it may play a role in epididymal maturation and male fertility. The goals of this study were to (a) verify the possible interaction between 17β-estradiol and equine PDIA1 using bioinformatics; (b) identify and quantify PDIA1 protein in equine cauda epididymis throughout peripuberty; and (c) determine whether the amounts of PDIA1 in equine seminal plasma and spermatozoa are associated with fertility. Using...
Matthews SM, Joysey VC.Fifteen equine leucocyte antigens were defined by absorption and titration analysis of alloantisera obtained by natural sensitisation through pregnancy and by planned experimental immunisation. Definitive sera were tested on the cells of 90 unrelated horses and members of eight equine families. The family data suggested that 13 specificities were coded by a single locus (first locus) and one specificity (Eq 14) was coded by a second linked locus. The remaining specificity (Eq 7) was controlled by a third locus unlinked to the first or second loci. Tests on the cells of unrelated horses showed ...
Newman MJ, Beegle KH, Antczak DF.Monoclonal antibodies to equine lymphocyte antigens were produced, using normal peripheral blood lymphocytes as the immunogen and standard hybridoma techniques. Antibody producing hybridomas were detected by a solid-phase enzyme-linked immunosorbent assay. Antibodies produced by 6 cloned hybrids were characterized further by microlymphocytotoxicity, indirect immunofluorescence, and agglutination assays on peripheral blood lymphocytes, platelets, and erythrocytes. Reaction patterns on leukocytes indicated that these antibodies may recognize at least 3 different cell-surface antigens: (1) an ant...
Pichardo M.Analysis of the morphological characters in North and South American horses present during Paleoindian time indicates that at least eight Equus ecospecies occurred in North America. In South America, Equus had radiated into four ecospecies, Hippidion had one, and Onohippidium had three geographically separate ecospecies. These species are found in archeological deposits ranging from ca. 13,000 to 8,000 yr B.P., in tropical habitats as well as in the high Andean and Patagonian colder ecotopes.
Klonisch T, Ryan PL, Yamashiro S, Porter DG.To determine the site of relaxin gene expression in equine placentae, a set of degenerate oligonucleotide primers was made according to the published amino acid sequence of the A- and B-chain of equine relaxin (eRXN). Total cellular RNA (tcRNA) from equine placentae at about 120 and 300 days of pregnancy was subjected to reverse transcriptase-polymerase chain reaction (RT-PCR) with use of these primers. A single amplification product of approximately 430 bp was detected in each case by agarose gel electrophoresis. The PCR product was ligated into Bluescript plasmid and sequenced to confirm the...
van Leeuwen W.A number of findings on twin pregnancies in mares recently reported in the literature are evaluated in the present paper. From these findings it emerges that twin pregnancies in mares very rarely develop from a synchronous (less than 2 days apart) double ovulation but rather from an asynchronous (much greater than 2 days apart) double ovulation. The significance of these findings in daily practice is pointed out. Moreover, it was found that in more than 50 per cent of the cases in which twin pregnancies had been diagnosed about day 20, one embryo had died by day 36. From this fact it is conclu...
The Journal of heredityMarch 6, 1998
Volume 89, Issue 1 104-106 doi: 10.1093/jhered/89.1.104
Duffield DA, Goldie PL.In a study of 2,786 tobiano and non-tobiano horses involved in paint horse breeding programs throughout the United States, the inheritance of the tobiano color pattern gene was tracked in pedigrees using the tightly linked polymorphic albumin gene. The dominant tobiano allele (T(o)), which produces the tobiano spotting pattern in horses, was in coupling with both AIA and AIB alleles at the albumin locus. The frequency of the T(o):AIA linkage phase among all the homozygous tobiano horses in this study including offspring and parents (N = 127), was 0.08. The T(o):AIB linkage phase was the most f...
