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Topic:Prognosis

Prognosis in horses refers to the prediction of the likely outcome or course of a disease or injury in equine patients. It involves assessing various factors such as the nature and severity of the condition, the horse's overall health, and response to treatment. Prognostic evaluations help veterinarians and horse owners make informed decisions regarding treatment options, management strategies, and potential recovery. The process often incorporates clinical assessments, diagnostic tools, and historical data to estimate the chances of recovery or progression. This page compiles peer-reviewed research studies and scholarly articles that explore methodologies, factors influencing prognostic outcomes, and the implications of prognostic evaluations in equine veterinary practice.
Penile and preputial squamous cell carcinoma in the horse: a retrospective study of treatment of 77 affected horses.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 6 533-537 doi: 10.2746/042516408X281171
van den Top JG, de Heer N, Klein WR, Ensink JM.The most common penile and preputial neoplasm in the horse is the squamous cell carcinoma (SCC), but no large surveys of treatment and effects of the grade of the tumour, based on the degree of differentiation, on outcome of affected horses are available. Objective: Analysis of treatment of male horses affected with SCC of the external genitalia and long-term results of treatment. Methods: Seventy-seven cases of SCC were evaluated. Data recorded included treatment, outcome, post operative histopathology and retrospective tumour grading. Results: Treatments included: cryosurgery, excision, part...
Gastric and small intestinal ileus as a cause of acute colic in the post parturient mare.
Equine veterinary journal    May 17, 2008   Volume 40, Issue 4 368-372 doi: 10.2746/042516408X302483
Hillyer MH, Smith MR, Milligan PJ.Ileus (functional obstruction of aboral gastrointestinal transit) is an uncommon cause of gastrointestinal dysfunction and colic in the horse. A number of specific conditions have been previously reported in association with ileus. This report describes the recognition of primary gastric and small intestinal ileus of undetermined cause in a series of post parturient mares. Objective: To describe the clinical features, treatment and outcome of a series of episodes of primary gastric and small intestinal ileus. Methods: A retrospective study was performed of colic episodes seen in an equine prac...
Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses.
Journal of the American Veterinary Medical Association    May 16, 2008   Volume 232, Issue 10 1515-1520 doi: 10.2460/javma.232.10.1515
Waselau M, Sutter WW, Genovese RL, Bertone AL.To determine outcome of Standardbred racehorses with moderate to severe midbody suspensory ligament desmitis (MSD) treated by means of ultrasound-guided intralesional injection of a single dose of platelet-rich plasma (PRP) followed by a program of gradually increased exercise. Methods: Nonrandomized clinical trial. Methods: 9 Standardbred racehorses. Methods: Following injection of PRP, horses were allowed a controlled, gradual return to exercise. Race records for the year prior to injury and for 3 consecutive years after horses returned to racing were reviewed. For comparison purposes, race ...
Equine diseases caused by known genetic mutations.
Veterinary journal (London, England : 1997)    May 9, 2008   Volume 179, Issue 3 336-347 doi: 10.1016/j.tvjl.2008.03.016
Finno CJ, Spier SJ, Valberg SJ.The recent development of equine genome maps by the equine genome community and the complete sequencing of the horse genome performed at the Broad Institute have accelerated the pace of genetic discovery. This review focuses on genetic diseases in the horse for which a mutation is currently known, including hyperkalemic periodic paralysis, severe combined immunodeficiency, overo lethal white syndrome, junctional epidermolysis bullosa, glycogen branching enzyme deficiency, malignant hyperthermia, hereditary equine regional dermal asthenia, and polysaccharide storage myopathy. Emphasis is placed...
Surgical treatment of carpal flexural deformity in 72 horses.
Australian veterinary journal    May 6, 2008   Volume 86, Issue 5 195-CE1 doi: 10.1111/j.1751-0813.2008.00275.x
Charman RE, Vasey JR.Carpal flexural deformities (CFD) are frequently encountered in the horse, with both congenital and acquired forms described. The success of surgical correction of CFD, both in terms of the ability to achieve a straight palmar carpal angle and the impact on future athletic performance, requires further investigation. Objective: To report the surgical management and outcome of treatment of flexural deformity of the carpus in 72 horses up to 12 months of age. Methods: Information was obtained from the medical records of horses surgically treated for CFD and through follow-up contact with owners....
Transvenous electrical cardioversion of equine atrial fibrillation: patient factors and clinical results in 72 treatment episodes.
Journal of veterinary internal medicine    May 2, 2008   Volume 22, Issue 3 609-615 doi: 10.1111/j.1939-1676.2008.0081.x
McGurrin MK, Physick-Sheard PW, Kenney DG.Transvenous electrical cardioversion (TVEC) has been developed for treatment of atrial fibrillation (AF) in horses. The relationship among patient variables, treatment response, and outcome in a typical referral population has not been evaluated. Objective: Patient variables such as age, sex, weight, and duration of arrhythmia affect prognosis for response to treatment and the energy level at which cardioversion occurs. Methods: TVEC was applied to 72 episodes of lone AF in 63 client-owned performance horses, with the majority (54) being Standardbred racehorses. Methods: Catheterization of the...
Periparturient hemorrhage in mares: 73 cases (1998-2005).
Journal of the American Veterinary Medical Association    May 2, 2008   Volume 232, Issue 9 1345-1351 doi: 10.2460/javma.232.9.1345
Arnold CE, Payne M, Thompson JA, Slovis NM, Bain FT.To determine signalment, physical examination and clinicopathologic abnormalities, outcome, and subsequent fertility of mares with periparturient hemorrhage (PPH) and identify factors associated with outcome (ie, survival vs death). Methods: Retrospective case series. Methods: 73 mares. Methods: Medical records were reviewed for information on age, breed, initial complaint, physical examination and clinicopathologic abnormalities, treatment, outcome, and subsequent fertility. Results: Median age was 14.0 years (range, 5 to 24 years), and median number of foals produced prior to the diagnosis o...
Indications for and short- and long-term outcome of permanent tracheostomy performed in standing horses: 82 cases (1995-2005).
Journal of the American Veterinary Medical Association    May 2, 2008   Volume 232, Issue 9 1352-1356 doi: 10.2460/javma.232.9.1352
Chesen AB, Rakestraw PC.To identify indications for and short- and long-term outcome of permanent tracheostomy performed in standing horses. Methods: Retrospective case series. Methods: 82 horses undergoing permanent tracheostomy. Methods: Data obtained from medical records included signalment, diagnosis, surgical technique, complications, use of the horse before and after surgery, and owner satisfaction. Follow-up information was obtained through a telephone questionnaire administered to owners. Results: Indications for permanent tracheostomy included nasopharyngeal cicatrix (n = 59), arytenoid chondropathy (55), an...
Options for treatment of cecocolic intussusception in horses.
Journal of the American Veterinary Medical Association    April 30, 2008   Volume 232, Issue 8 1134 
Freeman DE.No abstract available
Large colon resection and anastomosis in horses: 52 cases (1996-2006).
Equine veterinary journal    March 7, 2008   Volume 40, Issue 4 342-347 doi: 10.2746/042516408X293529
Driscoll N, Baia P, Fischer AT, Brauer T, Klohnen A.Large colon resection and anastomosis (LCRA) is the most aggressive method of surgical management of a colon with questionable viability. Currently, published studies are comprised mostly of broodmares and discuss short-term survival. Objective: To determine the prognosis for survival after LCRA in a diverse population of horses, report the incidence of post operative complications, and determine if associations between analysed variables and survival rate exist. Methods: The medical records of 52 horses that underwent LCRA were evaluated. Data were used to identify univariable associations wi...
Surgical management of a progressive iris melanocytoma in a Mustang.
Veterinary ophthalmology    February 28, 2008   Volume 11, Issue 2 75-80 doi: 10.1111/j.1463-5224.2008.00603.x
Scotty NC, Barrie KB, Brooks DE, Taylor D.A 7-year-old gray Mustang gelding weighing 454 kg was presented for evaluation of a brown mass within the left eye (OS) of 1 year's duration with recent enlargement. Results: A nonpainful, 8 mm diameter, brown, vascularized mass was identified in the anterior chamber of the OS. Ocular B-scan ultrasound confirmed iris involvement and corneal endothelial contact. Histopathology confirmed the presumptive diagnosis of a uveal melanocytic neoplasm, and revealed 1-3 mitotic figures per high power (400x) field. Results: The mass was removed via sector iridectomy without complications, but without com...
Left ventricular remodeling is associated with the severity of mitral regurgitation after inaugural anterior myocardial infarction–optimal timing for echocardiographic imaging.
American heart journal    February 21, 2008   Volume 155, Issue 5 959-965 doi: 10.1016/j.ahj.2007.12.007
Ennezat PV, Darchis J, Lamblin N, Tricot O, Elkohen M, Aumégeat V, Equine O, Dujardin X, Saadouni H, Le Tourneau T, de Groote P, Bauters C.Although mitral regurgitation (MR) has been associated with an increased risk of death and heart failure after myocardial infarction (MI), the relationship between post-MI MR and left ventricular (LV) remodeling has not been entirely clarified. In addition, the optimal timing for assessing MR after MI remains unknown. Methods: Post-MI MR was assessed by Doppler echocardiography at hospital discharge (baseline) and after 3 months in 261 patients with an inaugural anterior MI. We studied LV remodeling during a 1-year period and clinical follow-up after 3 years, according to MR severity at baseli...
Short incomplete sagittal fractures of the proximal phalanx in ten horses not used for racing.
Veterinary surgery : VS    February 7, 2008   Volume 37, Issue 2 193-200 doi: 10.1111/j.1532-950X.2007.00359.x
Kuemmerle JM, Auer JA, Rademacher N, Lischer CJ, Bettschart-Wolfensberger R, Fürst AE.To describe short incomplete sagittal fractures of the proximal phalanx (type Ia P1 fractures) in horses not used for racing and report outcome. Methods: Retrospective study. Methods: Horses (n=10) with type Ia P1 fractures. Methods: Retrieved data of horses with type Ia P1 fractures were signalment, history and results of orthopedic examination. Radiographs were re-evaluated for position and length of the fracture line, presence of osteoarthritis or subchondral cystic lesions (SCL), periosteal new bone formation and subchondral sclerosis. Conservative treatment (n=4) included box confinement ...
Admission clinicopathological data, length of stay, cost and mortality in an equine neonatal intensive care unit.
Journal of the South African Veterinary Association    February 2, 2008   Volume 78, Issue 3 153-157 doi: 10.4102/jsava.v78i3.308
Saulez MN, Gummow B, Slovis NM, Byars TD, Frazer M, MacGillivray K, Bain FT.Veterinary internists need to prognosticate patients quickly and accurately in a neonatal intensive care unit (NICU). This may depend on laboratory data collected on admission, the cost of hospitalisation, length of stay (LOS) and mortality rate experienced in the NICU. Therefore, we conducted a retrospective study of 62 equine neonates admitted to a NICU of a private equine referral hospital to determine the prognostic value of venous clinicopathological data collected on admission before therapy, the cost of hospitalisation, LOS and mortality rate. The WBC count, total CO2 (TCO2) and alkalin...
Analysis of factors influencing prognosis in foals with septic arthritis.
Irish veterinary journal    February 1, 2008   Volume 61, Issue 2 102-106 doi: 10.1186/2046-0481-61-2-102
Vos NJ, Ducharme NG.The purpose of this paper was to identify factors that would positively or negatively affect the short-term survival rate of foals with septic arthritis. Medical records of 81 foals (≤seven months of age) with a clinical diagnosis of septic arthritis, referred to the equine hospital at Cornell University Hospital for Animals, between 1994 and 2003 were reviewed. Signalment, age at presentation, number of affected joints, joint fluid parameters, bacterial agents, treatment modalities and year of treatment were compared between survivors and nonsurvivors. Sixty-two of 81 foals (77%) were disch...
The ecology of horse cyathostomin infective larvae (Nematoda-Cyathostominae) in tropical southeast Brazil.
Veterinary parasitology    January 30, 2008   Volume 153, Issue 1-2 100-107 doi: 10.1016/j.vetpar.2008.01.027
Quinelato S, Couto MC, Ribeiro BC, Santos CN, de Souza LS, Dos Anjos DH, Sampaio IB, Rodrigues LM.Experimental studies about the recovery, survival and migration to pasture of cyathostomin infective larvae (L(3)) from fresh feces depositions were conducted from February 2005 to March 2007 in a tropical region of southeast Brazil. Grass and feces were collected weekly at 8 a.m., 1 and 5 p.m. and processed by the Baermann technique. Multivariate analysis (principal components method) showed the influence of time and environmental variables on the number of infective larvae recovered from the feces and pasture. In the rainy period (October-March), more infective larvae were recovered on the f...
Lymphangiosarcoma in the nictitating membrane of a horse. Puff C, Herder V, Philipp A, Baumgärtner W.A 15-year-old Haflinger gelding presented with a mass in the left nictitating membrane. Two biopsies and the excised nictitating membrane were taken at different time points as a result of reoccurrence of the mass and submitted for histopathologic evaluation. The horse was euthanized as a result of poor prognosis following the reoccurrence of the mass after surgical removal. Histologically, the mass consisted of dilated, thin-walled vascular clefts and channels, lined by flattened to cuboidal endothelial cells with moderate cellular pleomorphism. There was up to 1 mitotic figure per high power...
Retrospective study of palmar/plantar annular ligament injury in 71 horses: 2001-2006.
Equine veterinary journal    January 4, 2008   Volume 40, Issue 3 237-244 doi: 10.2746/042516408X271217
Owen KR, Dyson SJ, Parkin TD, Singer ER, Kristoffersen M, Mair TS.Constriction of the digital flexor tendon sheath (DFTS) and its contents by the palmar/plantar annular ligament (PAL) is well recognised. However, primary injury of the PAL has not been well documented. Objective: To describe the clinical features of PAL injury, determine its prevalence with or without subcutaneous fibrosis and/or concurrent injury within the DFTS, and assess response to treatment. Methods: Horses were selected for inclusion based upon clinical features consistent with PAL injury and the presence of a thickened PAL (> or =2 mm) verified ultrasonographically. A retrospective...
Vaccination of sarcoid-bearing donkeys with chimeric virus-like particles of bovine papillomavirus type 1.
The Journal of general virology    December 20, 2007   Volume 89, Issue Pt 1 148-157 doi: 10.1099/vir.0.83267-0
Ashrafi GH, Piuko K, Burden F, Yuan Z, Gault EA, Müller M, Trawford A, Reid SWJ, Nasir L, Campo MS.Equine sarcoids are fibroblastic skin tumours affecting equids worldwide. While the pathogenesis is not entirely understood, infection with bovine papillomavirus (BPV) type 1 (and less commonly type 2) has been implicated as a major factor in the disease process. Sarcoids very seldom regress and in fact often recrudesce following therapy. Nothing is known about the immune response of the equine host to BPV. Given that the viral genes are expressed in sarcoids, it is reasonable to assume that vaccination of animals against the expressed viral proteins would lead to the induction of an immune re...
Toxins affecting the urinary system.
The Veterinary clinics of North America. Equine practice    December 7, 2007   Volume 23, Issue 3 677-vii doi: 10.1016/j.cveq.2007.09.001
Schmitz DG.Many different substances can induce toxic damage to various structural components of the equine kidney, and most lack pathognomonic signs. Some of these agents have specific treatments, although many do not. Supportive and symptomatic therapy is an important aspect of treatment of most cases of equine nephrotoxicosis. Regardless of cause, if the toxic substance is removed or neutralized before significant renal damage, full recovery of renal function may occur. Many horses already have significant renal damage before a definitive diagnosis is made, and the prognosis for full recovery thus rem...
Primary and secondary limb cellulitis in horses: 44 cases (2000-2006).
Journal of the American Veterinary Medical Association    December 7, 2007   Volume 231, Issue 11 1696-1703 doi: 10.2460/javma.231.11.1696
Adam EN, Southwood LL.To determine historical, physical, and microbiologic findings in horses with limb cellulitis and identify factors associated with short- and long-term outcome. Methods: Retrospective case series. Methods: 44 horses with limb cellulitis. Methods: Information obtained from medical records included use, history, affected limb, diagnostic procedures, treatment, and short-term outcome. Long-term follow-up information was obtained by means of a telephone survey. Results: Twenty-four horses had primary cellulitis, and 18 of the 24 (75%) had a hind limb affected. Results of microbiologic culture were ...
Magnetic resonance imaging features of proximal metacarpal and metatarsal injuries in the horse. Brokken MT, Schneider RK, Sampson SN, Tucker RL, Gavin PR, Ho CP.Magnetic resonance (MR) imaging abnormalities in horses with lameness localized to the proximal metacarpal or metatarsal region have not been described. To accomplish that, the medical records of 45 horses evaluated with MR imaging that had lameness localized to either the proximal metacarpal or metatarsal region were reviewed. Abnormalities observed in the proximal suspensory ligament or the accessory ligament of the deep digital flexor tendon included abnormal high signal, enlargement, or alteration in shape. Twenty-three horses had proximal suspensory ligament desmitis (13 hindlimb, 10 fore...
Outcome of medical and surgical treatment of cecal impaction in horses: 114 cases (1994-2004).
Journal of the American Veterinary Medical Association    November 3, 2007   Volume 231, Issue 9 1378-1385 doi: 10.2460/javma.231.9.1378
Plummer AE, Rakestraw PC, Hardy J, Lee RM.To determine short- and long-term outcomes, including recurrence rates, for horses with cecal impaction treated medically or surgically. Methods: Retrospective case series. Methods: 114 horses. Methods: Medical records were reviewed for information on signalment, history, clinical findings, treatment (medical vs surgical), and short-term outcome. Information on longterm outcome was obtained through a mail survey and telephone interview with owners. Results: 54 horses were treated medically, 49 horses were treated surgically, and 11 horses were euthanized after initial examination without furth...
Blood glucose in horses with acute abdominal disease.
Journal of veterinary internal medicine    October 18, 2007   Volume 21, Issue 5 1099-1103 doi: 10.1892/0891-6640(2007)21[1099:bgihwa]2.0.co;2
Hollis AR, Boston RC, Corley KT.Hyperglycemia in critically ill humans is associated with increased glucose production and insulin resistance and is associated with death. This might also be true in horses presenting with acute abdominal disease. Objective: Throughout hospitalization, hyperglycemia will be common in adult horses presenting with acute abdominal disease. Hyperglycemia will be associated with a worse prognosis for survival to hospital discharge. Methods: Two hundred sixty-nine adult horses with acute abdominal disease. Methods: Observational retrospective study. Records were reviewed for 269 horses that had glu...
Surgical management of small intestinal incarceration through the gastrosplenic ligament: 14 cases (1994-2006).
Journal of the American Veterinary Medical Association    October 17, 2007   Volume 231, Issue 8 1221-1224 doi: 10.2460/javma.231.8.1221
Jenei TM, García-López JM, Provost PJ, Kirker-Head CA.To determine prevalence, clinical findings, and long-term survival rate after surgery associated with incarceration of the small intestine through the gastrosplenic ligament (ISIGL) in horses. Methods: Retrospective case series. Methods: 14 horses with ISIGL. Methods: Medical records of horses with ISIGL examined between January 1994 and December 2006 were reviewed. Signalment, initial physical examination findings, results of abdominal fluid analysis, and clinical laboratory values were recorded, along with surgical findings, including segment of incarcerated intestine and surgical procedures...
Surgical management and outcome of a type-III Salter-Harris fracture of the frontal plane of the distal radial physis in a foal.
New Zealand veterinary journal    October 12, 2007   Volume 55, Issue 5 248-252 doi: 10.1080/00480169.2007.36777
Rutherford DJ, Textor J, Fretz PB.A 4-week-old Thoroughbred filly presented with lameness of acute, severe onset of the left foreleg (LF) of 3 days' duration. Results: Diffuse swelling was present around the distal radius and carpus of the LF. Carpal varus that could be reduced manually was present. Radiographs revealed an intra- articular frontal-plane fracture in the distal radial epiphysis, which continued cranially through the distal radial physis (DRP). The lateral aspect of the DRP was wider than expected. Latero-medial carpal instability was resolved by placement of a lag screw from the dorsal midline through the epiphy...
Decreased radiopharmaceutical uptake (photopenia) in delayed phase scintigraphic images in three horses. Levine DG, Ross BM, Ross MW, Richardson DW, Martin BB.Decreased radiopharmaceutical uptake, photopenia, in delayed phase scintigraphic images is recognized in people but has only been reported rarely in horses. We describe three horses with septic osteitis, bone sequestrum formation, or distal limb thrombosis that had photopenia of the affected extremity. Photopenia may indicate the presence of ischemia and can be used to facilitate clinical decision making and prognosis assessment
Use of matrix metalloproteinases 2 and 9 and white blood cell counts in monitoring the treatment and predicting the survival of horses with septic arthritis.
The Veterinary record    September 11, 2007   Volume 161, Issue 10 329-334 doi: 10.1136/vr.161.10.329
Kidd JA, Barr AR, Tarlton JF.Thirty-nine samples of synovial fluid were collected from the joints of 32 horses with suspected septic arthritis and 39 samples were collected from horses euthanased for non-orthopaedic conditions. The white blood cell counts (WBCC) were determined and the pro and active forms of matrix metalloproteinases (MMPs) 2 and 9 were measured by gelatin zymography and image analysis in each sample. The initial measurements of the ratio of proMMP9:proMMp2 and WBCC were good prognostic indicators of the survival of the horses. There was no significant relationship between the interval between the injury...
Magnetic resonance imaging features of oblique and straight distal sesamoidean desmitis in 27 horses. Sampson SN, Schneider RK, Tucker RL, Gavin PR, Zubrod CJ, Ho CP.Injury to the oblique and straight distal sesamoidean ligaments is becoming recognized as a more common cause of lameness in horses than was previously thought. The purpose of this study was to review the magnetic resonance (MR) imaging findings of 27 horses affected with desmitis of the oblique and/or straight distal sesamoidean ligament and determine long-term prognosis for horses with this diagnosis. Imaging was performed with horses in right lateral recumbency in a high-field 1 T magnet. All horses had lameness localized to the digit or metacarpophalangeal/metatarsophalangeal joint region ...
Plasma lactate as a predictor of colonic viability and survival after 360 degrees volvulus of the ascending colon in horses.
Veterinary surgery : VS    August 10, 2007   Volume 36, Issue 6 563-567 doi: 10.1111/j.1532-950X.2007.00305.x
Johnston K, Holcombe SJ, Hauptman JG.To determine the relationship between plasma lactate concentration and colonic viability and survival in horses with >or=360 degrees volvulus of the ascending colon. Methods: Retrospective study. Methods: Horses (n=73) with >or=360 degrees volvulus of the ascending colon. Methods: Medical records (January 2000-November 2005) of all horses examined for colic at Michigan State University Veterinary Teaching Hospital were reviewed. Horses were included only if plasma lactate concentration was measured preoperatively and a diagnosis of >or=360 degrees volvulus of the ascending colon was c...
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