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Topic:Veterinary Medicine
Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
Distribution of cardiac output in anaesthetised horses. The radioactive microsphere method was used to determine the distribution of cardiac output in six anaesthetised ponies. Simultaneous measurements of cardiac output allowed calculation of the tissue perfusions (ml/min/100 g). Allowing for the fact that measurements were carried out on animals under halothane anaesthesia and which had respiratory acidosis, the results were comparable with published values for other species.
Effect of exercise, phenylbutazone, and furosemide on the plasma renin activity and angiotensin I in horses. Circulating concentrations of angiotensin I and plasma renin activity (PRA) were determined in 45 Thoroughbreds before prerace medication (at rest), 1 to 1 1/2 hours before racing but after prerace medication (prerace), within 15 minutes after racing (immediately postrace), and between 1 to 2 hours after racing. Angiotensin I was measured by radioimmunoassay, and PRA was determined by the rate of generation of angiotensin I in plasma incubated at 37 C. Irrespective of prerace medication, there was a marked increase in angiotensin I (0.478 +/- 0.034 to 0.848 +/- 0.051 ng/ml) and PRA (0.191 +/- ...
Pharmacokinetics of ketamine in the horse. Ketamine HCl was administered IV to xylazine HCl-treated horses. The plasma concentration of ketamine was measured several times after administration of the drug and these data were used to develop a two-compartment pharmacokinetic model. The distribution and the elimination phase half-lives averaged 2.9 and 42 minutes. The volume of the central compartment averaged 212 ml/kg of body weight and the volume of the peripheral compartment was approximately threefold larger. The total body clearance of ketamine averaged 26.6 ml/minute/kg. Plasma protein binding of ketamine averaged 50% over the con...
The effects of repeated administration of Escherichia coli lipopolysaccharides to ponies. Repeated exposure of ponies in Escherichia coli endotoxin resulted in attenuation of the packed cell volume, beta-glucuronidase, capillary refill time and neutrophil responses usually accompanying endotoxin administration. An overall decrease in severity of clinical response including reduced mortality was also apparent in ponies with repeated endotoxin exposure. Modification of the febrile response was not observed in any of the experimental groups.
Endoscopic observations on the deglutition reflex in the horse. Cine-endoscopy was used to study the deglutition reflex in 2 apparently normal horses. Closure of the nasopharyngeal sphincter was brought about by a lowering of the pharyngeal roof and an elevation of the soft palate caudal to the pharyngeal ostia of the auditory tubes. The medial cartilages of the ostia were not directly involved in bringing about closure of the sphincter. It is postulated that the opening of the ostia of the auditory tubes is brought about during deglutition by the combined action of the palatopharyngeus, pterygopharyngeus and tensor veli palatini muscles.
Granular cell tumour (myoblastoma) in the lung of a horse. A granular cell tumour (myoblastoma) occurred in the lung of an aged mare. Multiple greyish-white neoplastic nodules of various sizes almost replaced one lung. Histologically, the neoplasm consisted of small clumps of granular cells in a stroma composed of thick bands of collagen and numerous capillaries. The globoid or stellate neoplastic cells were characterized by a large number of eosinophilic, PAS-positive, diastase-resistant cytoplasmic granules. Ultrastructurally, the granules were of two types: (a) homogeneous, electron-dense granules and (b) multimorphous granules that resembled cell ...
Atypical salmonellosis in horses: fever and depression without diarrhea. Salmonellosis in horses may result in fever, anorexia, and depression without concurrent diarrhea or other obvious gastrointestinal abnormalities and should be considered in cases of fever of unknown origin. The syndrome also is characterized by neutropenia, usually with a left shift, and growth of small numbers of salmonella from feces cultured in selenite enrichment broth. Repeated culturing may be necessary to isolate the organism. All six affected horses of this report recovered in 3 to 7 days without specific therapy.
A preliminary report on the use of warfarin in the treatment of navicular disease. Twenty horses suffering from navicular disease were treated with warfarin given orally. The dosage was to effect, to give a 2 to 4 second prolongation of the one stage prothrombin time (OSPT). Dosage was initially at a rate of 0.018 mg/kg, changing the dose by amounts of 20 per cent until the required dose was achieved. Final dose rates varied from 0.012 mg/kg to 0.75 mg/kg. All the cases treated received warfarin daily throughout the trial. Seventeen of the animals became sound and the remaining 3 showed a marked improvement in their gait. The mean of the ages of the horses was 7.5 years, the...
Identification and characterisation of the major antiproteases in equine serum and an investigation of their role in the onset of chronic obstructive pulmonary disease (COPD). Three major antiprotease components in equine serum were identified and characterised. These were the acidic prealbumin Pr, the homologue of human alpha-1 antitrypsin and 2 protease binding proteins, the acidic prealbumin Xc and alpha-2 macroglobulin, both capable of inhibiting the proteolytic activity of trypsin, but with only limited inhibitory effect on its esterolytic activity. The possible role of these serum antiproteases in the onset of chronic obstructive pulmonary disease (COPD), analogous to the hereditary dysproteinaemia of alpha-1 antitrypsin in man, was investigated. There was no ...
Sound spectography in the diagnosis of equine respiratory disorders: a preliminary report. One problem in the diagnosis of subclinical roarers is that abnormal auditory signals occur only during a fast gait, and these fade quickly. This paper offers a novel technique to assist this problem. Sound recordings were obtained from five horses following exercise; two roarers, two non-roarers, and one suspected roarer. These signals were converted into spectrograms by Rayspan processing. All frequencies in the 0 to 2.25 kHz range during both inspiration and expiration, as well as occasional noises in the 2–4 kHz band, characterised roarers. Signals from non-roarers consisted of frequenci...
An equine fetal monster dicephalus tetrapus dibrachius. Double monsters are structurally related to monozygotic twins and the reported frequency of these abnormalities in the equine species is low. Symmetrical, double development in both the cephalic region and caudal trunk was demonstrated along with a common undeveloped cervical mass. Anomalies found in the separate genito-urinary systems added another variant to this case.
Fluoroscopic investigation of pharyngeal function in the horse. Videofluoroscopy was used to study the deglutition reflexin 2 horses believed, on the basis of endoscopic and clinical examination, to have normal pharyngeal and laryngeal function. The reflex was found to be the same as that described in man and in the rabbit. A feature of deglutition in the horse was the temporary increase in size of the auditory tube diverticuli (gluttural pouches) as a result of contraction of the pharyngeal muscles.
In-vivo myometrial electrical activity in the cyclic mare. Uterine electromyography was performed by means of chronically implanted surface electrodes in 3 Pony mares during spontaneous oestrous cycles and following luteolysis induced by a prostaglandin analogue (fluprostenol). Three distinct patterns were recognized during the oestrous cycle. (1) During oestrus well defined phases of activity with closely grouped high-amplitude spikes were separated by long periods (10-45 min) of complete inactivity. (2) During dioestrus more diffuse phases of activity with low-amplitude spikes were separated by variable periods of relative inactivity. (3) During lut...
The epidemiology of equine strongylosis in southern Queensland. 2. The survival and migration of infective larvae on herbage. The seasonal changes in longevity on herbage of the infective larvae of strongylid nematodes of the horse were studied. During the summer months, 1% of the larvae survived on herbage for 2-3 weeks, with 0.2% still viable for a further 2-3 weeks. Equivalent survival periods in winter were 7-11 weeks and over 11 weeks respectively. During spring and autumn, larvae survived for periods varying from 3-8 weeks. On Rhodes grass (Chloris gayana) growing vigorously in the summer of 1976, the majority of larvae remained in the lowest layers of the pasture, within 10 cm of the soil surface. Very few rea...
Indirect measurement of mean blood pressure in the normotensive and hypotensive horse. Indirect mean arterial pressure was obtained from the tails of 78 anaesthetised and unanaesthetised normotensive and hypotensive horses. Data were obtained to determine the optimum cuff width in relation to tail circumference. A cuff that is too wide under-estimates and a cuff that is too narrow over-estimates blood pressure. With the optimum cuff width, which is slightly in excess of about one-fifth of the tail circumference, indirect mean blood pressure was obtained consistently in normotensive and hypotensive animals with mean blood pressures of 40 mmHg and frequently in animals with pressu...
Phonocardiography in the horse: 2. The relationship of the external phonocardiogram to intracardiac pressure and sound. The paper describes observations during individual cardiac cycles on the changing pressures and sounds recorded from the various chambers of the heart and aorta, related to phonocardiograms from an external microphone hand-held over the cardiac area. The majority of the first sound appears to arise from the left side of the heart after the AV valves have closed and the second sound is a consequence of sudden deceleration of blood against already closed semilunar valves. Systolic murmurs at the aortic root may be benign from increased flow and turbulence at the peak of ejection but these may no...
Chronic obstructive pulmonary disease (COPD): factors influencing the occurrence. Breed, age, weight, type of work performed, seasonal onset, poor ventilation and exposure to moulds in the habitat were investigated in relation to the occurrence of chronic obstructive pulmonary disease (COPD). COPD was most commonly detected in showjumping and hacking horses. The older a horse, the more likely it was to become affected although most were 6 to 10 years of age. Of the horses in this sample of the population, which was not a random one, thoroughbred horses were affected least and ponies most often. The high incidence in ponies was related to their more frequent exposure to poor...
The Fourth Sir Frederick Hobday Memorial Lecture. Back problems in the horse–a look at past, present and future progress. The horse is predisposed to back injury by virtue of the type of work and intensity of competition
to which it is subjected nowadays. This paper reviews some of the inherent difficulties in establishing meaningful criteria for the diagnosis and treatment of these injuries. It highlights some
of the large gaps in knowledge, particularly in relation to the causative factors involved and the
biomechanics of the equine spine. One controversial area in diagnosis and treatment concerns
the possible subluxation of vertebral dorsal spinous processes and their subsequent reposition by
means of man...
The presence of precipitating antibodies in the sera of horses with chronic obstructive pulmonary disease (COPD). The sera of horses affected and not affected with chronic obstructive pulmonary disease (COPD) were examined for precipitins to Micropolyspora faeni and Aspergillus fumigatus. Precipitins to both antigens were not restricted to COPD cases but occurred more frequently in animals affected with COPD. Many animals without detectable precipitins responded clinically to inhalation challenge with these antigens.
Chronic obstructive pulmonary disease (COPD) in horses: aetiological studies: responses to intradermal and inhalation antigenic challenge. Micropolyspora faeni and Aspergillus fumigatus were identified as common causes of respiratory hypersensitivity in horses affected with chronic obstructive pulmonary disease (COPD). Rye grass pollen and an Actinomycete evoked respiratory allergy in a few horses. Not infrequently, individual horses were found to have respiratory hypersensitivity to two or more antigens. The methods used to examine for allergy were intradermal testing and inhalation challenge with environmental antigens. An intradermal test using an M faeni extract was demonstrated to be suitable for diagnostic use in horses pre...
Survival of contagious equine metritis bacteria in transport media. Survival of bacteria that cause contagious equine metritis (CEM) was evaluated in Amies modified transport (AMT) medium, in AMT medium with charcoal, and in Stuart transport medium at 37, 22, 4, and -70 C. The CEM bacteria suspended in transport media survived at 22, 4, and -70 C for longer periods in AMT medium with charcoal than they did in AMT and Stuart transport media. In 1 day, the number of bacteria in exudate stored in the absence of any transport medium decreased 15-fold at 22 C and twofold at 4 C. The CEM bacteria were isolated from exudate on cotton-tipped swabs from all three trans...
Differential release of LH and FSH in cyclic mares in response to synthetic Gn-RH. Mares at different stages of the oestrous cycle were given a single intravenous injection of 0.5 mg synthetic Gn-RH. The mean area of the induced LH peak was significantly less at mid-cycle (Day 10-11) than at any other time. The mean height of the LH peak above preinjection concentration was greater at late oestrus and early cycle (Day 5-6) than at mid-cycle and early oestrus. There were no significant different in mean FSH responses. The LH:FSH ratio for both height and area of induced peaks was significantly less at mid-cycle than at other times of injection. These results suggest that one ...
Improved measurements of shear modulus and pleural membrane tension of the lung. The continuum solution for the deformation of an elastic half space covered by a membrane is used to interpret measurements of the indentation of lung lobes under a column of fluid. The shear modulus mu of the underlying parenchyma is found to be approximately 0.7 times transpulmonary pressure, independent of species size. The tension in the pleural membrane T increases rapidly with increasing membrane area. For dog lungs, the value of T is 10(3) to 10(4) dyn/cm. For the larger species tested, pigs and horses, T is larger. The continuum solution shows that a concentrated force applied to the p...
