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Topic:Veterinary Research
Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Venezuelan equine encephalitis virus: horse virulence of P-676 and MF-8 small and minute plaques. The P-676 and MF-8 epizootic strains of Venezuelan equine encephalitis (VEE) virus were found to contain a minute plaque (MP), different from the predominant small plaque (SP) present in these virus strains. The MP and SP were stable after passages in Vero cells, mice, or horses. Equines were inoculated with the SP or MP of the P-676 and MF-8 strains. Inoculation of either P-676 SP or MP into horses induced high fever and viremia but no signs of encephalitis or death. Four horses infected with MF-8 SP became very ill, with high fever and viremia; three of the inoculated animals died. Four hors...
Oxytetracycline hydrochloride in the horse: serum, synovial, peritoneal and urine concentrations after single dose intravenous administration. Six adult mares were given a single intravenous injection of oxytetracycline HCl (50 mg/ml) at a dosage of 5 mg/kg. Serum, synovial fluid, peritoneal fluid, and urine oxytetracycline concentrations were measured serially over a 48-h period. The highest measured serum oxytetracycline concentration was 8.01 mcg/ml at 1/2 h. Oxytetracycline was detected in synovial fluid and peritoneal fluid, which obtained mean peak oxytetracycline concentrations of 4.43 mcg/ml and 4.20 mcg/ml, at 1/2 h and 1 h, respectively. These concentrations steadily declined in parallel with serum concentrations and were n...
Cardiopulmonary effects of clenbuterol in the horse. Clenbuterol, a bronchospasmolytic agent (beta 2 agonist) was studied in terms of its hemodynamic and airflow response in eight, healthy horses. Four animals were instrumented to record intrapleural pressure and air flow, these were used to compute pulmonary resistance, peak flow rates, and tidal volumes. Four animals were instrumented to record pulmonary arterial pressure, carotid arterial pressure, cardiac output, and arterial gas tensions. After control values were recorded, clenbuterol (0.8 microgram/kg) was intravenously administered to each horse in each experiment group. Following clenbu...
Studies on the chromosomes and sex chromatin in the horse. This study provides accumulated data to assist the definition of karyotypes from normal and infertile horses. The normal karyotype of the horse (2n = 64) was characterized following Giemsa staining and C- banding, and 23% aneuploidy was found among chromosome counts of cells prepared from 44 clinically normal horses and 24 equine embryos. These expected variations in chromosome counts are especially important in the evaluation of potential mosaicism. Centromere staining was shown to be a valuable aid for the identification of specific chromosomes, in particular the sex chromosomes. Sex chromat...
Effect of exogenous hyaluronic acid on joint function in experimentally induced equine osteoarthritis: dosage titration studies. A single intra-articular injection of 20 or 40 mg of purified hyaluronic acid of rooster comb origin resulted in restoration of normal joint function in horses with experimentally induced osteoarthritis. The functional improvement, measured by pressure sensitive force plate techniques, was detectable within one week after treatment and persisted throughout a four week experimental period despite continued use of the joints. The response was dose dependent in that injection of 0 (saline), 5 or 10 mg hyaluronic acid per joint space resulted in no significant change in joint function while dosage...
The use of endometrial biopsy in the infertile mare. The results of a study on endometrial biopsies obtained from 700 infertile mares are reported. Infiltrative endometritis was present in 51% consisting of a combination of an acute and chronic cellular response in 6%, mild chronic infiltrations in 35% and moderate to severe chronic infiltrations in 10%. Demonstrable endometrial fibrosis was found in 88% of the mares with the majority having mild (51%) or moderate (35%) changes. The age of the mares and the average number of years barren gradually increased with the severity of endometrial fibrosis, as did the combined incidence of fetal loss (e...
The cleavage of the Met-Lys bond in a bradykinin derivative by glandular kallikreins. The synthetic tridecapeptide Gly-Leu-Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg was used as a model substrate for horse urinary and porcine pancreatic kallikreins. The Met-Lys bond is hydrolyzed selectively by both enzymes. Oxidation of the methionine residue to sulfoxide made the peptide resistant to both kallikreins. Substitution of either the methionine or lysine residues by norleucine led to peptides in which the Nle-Lys or the Met-Nle bonds, respectively, were susceptible to the urinary kallikrein. The esterolytic and Met-Lys bond-splitting activities of both enzymes were inhibited simil...
Growth rates at the extremities of limb bones in young horses. Measurements were made of growth at the extremities of all the long bones of the left limbs of 23 horses between 52 and 104 days of age. Growth rates were more rapid in the younger than in the older animals. Growth was more rapid in the hind limb than in the forelimb. Growth rates were greater for males than in females. Although this age group represents only two of the 60 or so months necessary for maturity to be reached, oxytetracycline bone-labelling produced results which are more precise than measurements obtained by other methods. This study provides a substantial amount of data for an a...
Hyperplastic goitre in newborn foals in Western Canada. Hyperplastic goitre was observed in seven newborn foals. Several were weak at birth and died in the first 48 hours of life. Only one foal had myxedema and only three of the seven had obvious enlargement of the thyroid at necropsy. It is suggested that the goitre observed was caused by a dietary deficiency of iodine.
Carpal bone lesions associated with angular limb deformities in foals. Six foals with angular limb deformities present at birth or shortly after were examined. The limb deformities were caused by abnormalities of the carpal bones and included hypoplasia and osteochondritis dissecans. The 3rd carpal bone was affected most frequently.
Bacillus piliformis infection (Tyzzer’s disease) in foals in northwestern United States: a retrospective study of 21 cases. From Jan 1, 1967 through June 1980, 21 cases of Bacillus piliformis infection (Tyzzer's disease) in foals were diagnosed at the Washington Animal Disease Diagnostic Laboratory. Affected foals died between 7 and 35 days of age. Of 4 Arabian foals with the disease, 2 also had combined immunodeficiency.
Evaluation of a surgical technique for repair of equine accessory carpal bone fractures. In 9 horses, osteotomies were performed to simulate accessory carpal bone fractures. Screw fixation, aided by a large C-clamp, was performed on 6 of the 9 horses. Three were treated conservatively, as controls, with fractures not repaired; they remained clinically lame throughout the 6-month study. Fibrocartilaginous nonunion developed in each of the 3 controls. At 150 days, the principals were free of lameness, with evidence of bony union. The results of clinical, radiographic, and pathologic evaluations showed surgical repair to be superior to prolonged rest in treating equine accessory carp...
Active immunisation of horses against tetanus including the booster dose and its application. Successful active immunisation of horses against tetanus is dependent on a number of factors of which the toxoid preparation used, its method of application and the ability of the individual horse to respond are fundamental. Two immunisation schedules using an aluminium-based toxoid preparation were examined and the protection determined by monitoring the level of antitoxin afforded by each schedule. The results obtained demonstrated that 2 doses of this toxoid are necessary to ensure 12 months protection in all horses. These results are discussed in relation to the factors involved in active ...
Tracheal reconstruction by resection and end-to-end anastomosis in the horse. A surgical technique for resection of a portion of the trachea followed by end-to-end anastomosis was developed on 4 clinically normal horses. The trachea healed without complications in 3 of the horses in which 3 tracheal cartilages were removed. Five tracheal cartilages were removed from the 4th horse. It had to be euthanatized because of excessive suture line tension and wound disruption, which occurred during recovery from anesthesia. Suture line tension was measured on 3 other clinically normal horses positioned in dorsal recumbency immediately after euthanasia after 3 and 5 tracheal cart...
Brainstem auditory evoked response in the diagnosis of inner ear injury in the horse. Brainstem auditory evoked response (BAER) testing was done to evaluate inner ear/VIIIth cranial nerve (CN8) function in the horse. The BAER test consisted of stimulating the auditory system with clicks and recording far-field responses of the brainstem auditory components via cutaneous electrodes and a signal averaging system. The normal response was shown to be a series of waves occurring within the first 10 msec after the stimulus click. Functional loss of the auditory receptor organ (cochlea) or CN8 results in loss of the entire response on the side of the injury. Because of the anatomic re...
Chronic catheterization of coronary sinus in large domestic animals. A technique was developed for long-term catheterization of the coronary sinus in calves and ponies. A catheter with a 10 to 12 cm-long stiff segment was implanted via right lateral thoracotomy. Catheters were kept patent up to 10 weeks after the surgical procedure. At that time, location of the catheter tip was confirmed both by determining oxygen tension of the anaerobically sampled blood and by radiography. Base-line values of oxygen venous blood of non-anesthetized calves and ponies are reported.
Radiographic detection and characterization of palmar lesions in the equine fetlock joint. Subchondral lesions were identified in the distal palmar region of the third metacarpus in 21 fetlock joints of 15 Thoroughbred horses. The lesions were more commonly identified on the lateromedial and flexed lateral projection, with the flexed lateral projection permitting optimal visualization of the lesion. Lesions appeared as poorly marginated, radiolucent defects and were located at the level of the base of the proximal sesamoid bones. The shape and distribution of the radiolucent defects were: crescent, 4; flattened, 4; shallow concavity, 5; deep concavity, 3; oval, 3; and circular, 2. S...
Development of the adrenal cortex in the fetal foal: an ultrastructural study. The adrenal cortex from twelve fetal foals (gestational ages from 61 to 300 days) was examined by light and electron microscopy. Adrenal glands from three newborn foals were also examined by light microscopy. Between 61 and 100 days of gestation the adrenal cortex became organised into two distinct regions, the zona glomerulosa and zona fasciculata, which grew steadily in thickness until the 300th day. Between 300 days and birth there was a dramatic increase in the width of the zona fasciculata. From 200 days a narrow band of compact cells marked the cortico-medullary border. Though these cell...
Evaluation of an intravenous catheter for use in the horse. A commercially available polyvinyl chloride intravenous catheter was studied in 9 horses for 3 to 10 days to evaluate the catheter's suitability for use in the horse, to develop a new insertion technique, and to establish a protocol for catheter care. Seven of the animals were clinically normal horses receiving parenteral nutrition; one was a horse with hypocalcemia receiving frequent intravenous injections of calcium gluconate, and one was a clinically normal horse receiving no infusions. The catheter dressings were changed every 48 hours, and an aspirate from the catheter and the catheter ti...
