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Veterinary journal (London, England : 1997)1998; 154(3); 189-202; doi: 10.1016/s1090-0233(97)80020-2

Aerosol therapy in the equine species.

Abstract: Inhalation therapy plays an increasing role in the management of equine respiratory disorders. This alternative to systematic treatment permits a high concentration of medication to act locally while minimizing side effects and residues. In human medicine, literature in this field is prolific and continuously renewed, whereas in veterinary medicine, applications of aerosol therapy are less extensive. This review considers the principles of action of the different types of devices used for inhalation, i.e., nebulization, metered-dose inhalation and dry powder inhalation, describes the technical and practical requirements for their use in the equine species and considers the advantages and disadvantages of each inhalation device. The pharmacological agents currently administered to horses by inhalation are also discussed. Perspectives of aerosol therapy in the equine species, including aerosols already used in human medicine and their potential applications for horses are described.
Publication Date: 1998-01-01 PubMed ID: 9414952DOI: 10.1016/s1090-0233(97)80020-2Google Scholar: Lookup
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Summary

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The research article discusses the use of aerosol therapy for respiratory disorders in horses. It compares the different inhalation devices used and reviews the practicality of their usage, and discusses the pharmacological agents administered to horses via inhalation.

Types of Inhalation Devices and their Principles of Action

  • The article reviews different inhalation devices used for aerosol therapy in equines: nebulization, metered-dose inhalation, and dry powder inhalation.
  • Nebulization involves the use of a device to create a mist of medicine that the horse can breathe in. The medicine is delivered directly to the respiratory system, providing fast relief with minimal side effects.
  • Metered-dose inhalers deliver a specific amount of medication in aerosol form. The horses can breathe this in by activating the device while breathing in.
  • Dry powder inhalators are similar to metered-dose inhalers, but the medication is in powder form. The horse inhales the medication directly into the lungs.

Technical and Practical Requirements

  • The use of these inhalation devices in the equine species requires specific technical knowledge and practical skills. The details of this aspect are not revealed in the summary, but they would probably involve training the horses to accept the devices and creating an environment conducive for therapy.
  • It’s important that these devices are used correctly to ensure they are effective and safe. Incorrect usage could lead to unnecessary side effects or insufficient treatment.

Advantages and Disadvantages of Inhalation Devices

  • The advantages of inhalation devices, according to the article, is their ability to deliver a high concentration of medication directly to the affected area, with minimal side effects and residues. This is because the medication doesn’t have to go through the digestive and circulatory system before reaching the lungs.
  • The disadvantages might include the cost of the devices, maintenance requirements, and the potential need for specialized training for both the horse and person administering the therapy.

Pharmacological Agents for Inhalation

  • The authors also discuss the pharmacological agents currently being administered to horses through inhalation. These would vary depending on the specific respiratory condition being treated.
  • These medications might include bronchodilators, corticosteroids, or anticholinergic agents, among others.

Future Perspective of Aerosol Therapy in the Equine Species

  • The authors consider potential future developments in equine aerosol therapy, including aerosols already used in human medicine and their potential applications for horses.
  • This could involve the development of new drugs or more efficient delivery systems, as well as research into more effective ways to use existing therapies.

Cite This Article

APA
Duvivier DH, Votion D, Vandenput S, Lekeux P. (1998). Aerosol therapy in the equine species. Vet J, 154(3), 189-202. https://doi.org/10.1016/s1090-0233(97)80020-2

Publication

ISSN: 1090-0233
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 154
Issue: 3
Pages: 189-202

Researcher Affiliations

Duvivier, D H
  • Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Belgium.
Votion, D
    Vandenput, S
      Lekeux, P

        MeSH Terms

        • Adrenal Cortex Hormones / administration & dosage
        • Adrenal Cortex Hormones / therapeutic use
        • Aerosols / adverse effects
        • Aerosols / standards
        • Animals
        • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
        • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
        • Bronchodilator Agents / administration & dosage
        • Bronchodilator Agents / therapeutic use
        • Cholinergic Antagonists / administration & dosage
        • Cholinergic Antagonists / therapeutic use
        • Cytokines / administration & dosage
        • Cytokines / therapeutic use
        • Dose-Response Relationship, Drug
        • Horse Diseases / drug therapy
        • Horses
        • Lung Diseases / drug therapy
        • Lung Diseases / veterinary
        • Nebulizers and Vaporizers / veterinary
        • Respiratory Therapy / adverse effects
        • Respiratory Therapy / standards
        • Respiratory Therapy / veterinary

        References

        This article includes 118 references

        Citations

        This article has been cited 2 times.
        1. Tell LA, Stephens K, Teague SV, Pinkerton KE, Raabe OG. Study of nebulization delivery of aerosolized fluorescent microspheres to the avian respiratory tract. Avian Dis 2012 Jun;56(2):381-6.
          doi: 10.1637/9989-111511-Reg.1pubmed: 22856198google scholar: lookup
        2. Bruhn O, Grötzinger J, Cascorbi I, Jung S. Antimicrobial peptides and proteins of the horse--insights into a well-armed organism. Vet Res 2011 Sep 2;42(1):98.
          doi: 10.1186/1297-9716-42-98pubmed: 21888650google scholar: lookup