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Home / Equine Research Bank / J Am Vet Med Assoc / Causes of and farm management factors associated with diseas...
Journal of the American Veterinary Medical Association1994; 204(10); 1644-1651;

Causes of and farm management factors associated with disease and death in foals.

Abstract: A prospective study was conducted to describe the causes of and farm management factors associated with disease and death in a population of foals in Texas. Data from 2,468 foals at 167 farms were provided by veterinarians for all 12 months during 1991. Among 2,468 foals, 116 deaths were reported (4.7%). Pneumonia was the most commonly reported cause of death, followed by septicemia. When considered as a group, musculoskeletal disorders (traumatic, infectious, or deforming problems) represented the most common cause of all reported deaths. Daily risk of death was greatest during the first 7 days of life, and decreased with age. Risk and frequency of causes of death varied by age. Crude incident morbidity during the year was 27.4% (677/2,468). Respiratory disease was the most common cause of incident disease in the study population, followed by diarrhea. Risk of disease was greatest among < or = 7 days old, and decreased with age. Crude rate of incident of diarrhea was significantly lower among farms where foals were born on pasture, compared with that at farms where foals were born in stalls. The practice of assessing passive immunity was significantly associated with decreased morbidity from septicemia and pneumonia.
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Publication Date: 1994-05-15 PubMed ID: 8050947
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article studies the causes of diseases and mortality in foals and its association with farm management practices. It concludes that pneumonia, septicemia, and musculoskeletal disorders are prominent causes of death, while respiratory disease and diarrhea are common illnesses. Moreover, a foal’s age and where they are born also play a significant role in disease occurrence, mortality, and disease type.

Research Background and Method

  • The researchers conducted a prospective study around Texas, collecting data from 2,468 foals across 167 farms. This data was gathered by veterinarians over 12 months in 1991.
  • During the study, the foals’ daily risk of death, disease frequency, age-related cause of death, and crude incident morbidity were observed and recorded.

Research Findings: Disease and Mortality

  • Among the total of 2,468 foals, 116 deaths occurred, representing a death rate of 4.7% for the whole population under review.
  • The main causes of death were pneumonia, followed by septicemia (blood poisoning), which was largely fatal.
  • Musculoskeletal disorders, including traumatic, infectious, or deforming problems were the most common cause of all reported deaths when considered as a group.
  • The study found that the risk of death was highest in the first week of life, decreasing as the foal matured.

Research Findings: Diseases

  • The study found the crude incident morbidity rate to be 27.4% which means 27.4% of the total population were expected to have a disease during the study period.
  • The most common cause of incident disease was respiratory disease, followed by diarrhea.
  • Similar to fatality risk, the risk of disease was greatest among foals less or equal to 7 days old, decreasing gradually with age.

Farm Management Factors

  • Where a foal is born significantly influences the disease incident. Foals born on pastures had a significantly lower rate of diarrhea compared to those born in stalls.
  • The practice of assessing passive immunity – the transfer of antibodies from mother to baby during breastfeeding, was associated with decreased morbidity from septicemia and pneumonia.

In summary, this study outlines the critical health risks for foals, the primary diseases present in this population, their correlation with the age of the foals and also indicates certain farm management practices that can be instrumental in maintaining better health for the foals.

Cite This Article

APA
Cohen ND. (1994). Causes of and farm management factors associated with disease and death in foals. J Am Vet Med Assoc, 204(10), 1644-1651.

Publication

Journal of the American Veterinary Medical Association
ISSN: 0003-1488
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 204
Issue: 10
Pages: 1644-1651

Researcher Affiliations

Cohen, N D
  • Department of Large Animal Medicine & Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843-4475.

MeSH Terms

  • Age Factors
  • Animal Husbandry
  • Animals
  • Animals, Newborn
  • Cause of Death
  • Diarrhea / epidemiology
  • Diarrhea / veterinary
  • Female
  • Horse Diseases / epidemiology
  • Horse Diseases / etiology
  • Horse Diseases / mortality
  • Horses
  • Immunity, Maternally-Acquired
  • Incidence
  • Male
  • Morbidity
  • Musculoskeletal Diseases / epidemiology
  • Musculoskeletal Diseases / mortality
  • Musculoskeletal Diseases / veterinary
  • Pneumonia / epidemiology
  • Pneumonia / mortality
  • Pneumonia / veterinary
  • Prospective Studies
  • Respiratory Tract Diseases / epidemiology
  • Respiratory Tract Diseases / veterinary
  • Risk Factors
  • Sepsis / epidemiology
  • Sepsis / mortality
  • Sepsis / veterinary
  • Texas / epidemiology

Citations

This article has been cited 39 times.
  1. Williams NJ, Slovis NM, Browne NS, Troedsson MHT, Giguėre S, Hernandez JA. Enterococcus durans infection and diarrhea in Thoroughbred foals. J Vet Intern Med 2022 Nov;36(6):2224-2229.
    doi: 10.1111/jvim.16568pubmed: 36285839google scholar: lookup
  2. Anna M, Łukasz M, Adam O, Chełmońska-Soyta A. Effectiveness of immunization with multi-component bacterial immunomodulator in foals at 35th day of life. Sci Rep 2022 Sep 22;12(1):15795.
    doi: 10.1038/s41598-022-17532-1pubmed: 36138050google scholar: lookup
  3. Migliorisi A, Barger A, Austin S, Foreman JH, Wilkins P. Hyponatremia in horses with septic pneumopathy. J Vet Intern Med 2022 Sep;36(5):1820-1826.
    doi: 10.1111/jvim.16522pubmed: 36054644google scholar: lookup
  4. Taylor SD, Serpa PBS, Santos AP, Hart KA, Vaughn SA, Moore GE, Mukhopadhyay A, Page AE. Effects of intravenous administration of peripheral blood-derived mesenchymal stromal cells after infusion of lipopolysaccharide in horses. J Vet Intern Med 2022 Jul;36(4):1491-1501.
    doi: 10.1111/jvim.16447pubmed: 35698909google scholar: lookup
  5. Rahman A, Uzal FA, Hassebroek AM, Carvallo FR. Retrospective study of pneumonia in non-racing horses in California. J Vet Diagn Invest 2022 Jul;34(4):587-593.
    doi: 10.1177/10406387221094273pubmed: 35535386google scholar: lookup
  6. Kahn SK, Cywes-Bentley C, Blodgett GP, Canaday NM, Turner-Garcia CE, Vinacur M, Cortez-Ramirez SC, Sutter PJ, Meyer SC, Bordin AI, Vlock DR, Pier GB, Cohen ND. Antibody activities in hyperimmune plasma against the Rhodococcus equi virulence -associated protein A or poly-N-acetyl glucosamine are associated with protection of foals against rhodococcal pneumonia. PLoS One 2021;16(8):e0250133.
    doi: 10.1371/journal.pone.0250133pubmed: 34437551google scholar: lookup
  7. Cohen ND, Kahn SK, Cywes-Bentley C, Ramirez-Cortez S, Schuckert AE, Vinacur M, Bordin AI, Pier GB. Serum Antibody Activity against Poly-N-Acetyl Glucosamine (PNAG), but Not PNAG Vaccination Status, Is Associated with Protecting Newborn Foals against Intrabronchial Infection with Rhodococcus equi. Microbiol Spectr 2021 Sep 3;9(1):e0063821.
    doi: 10.1128/Spectrum.00638-21pubmed: 34319137google scholar: lookup
  8. Wong DM, Young L, Dembek KA. Blood thiamine (vitamin B(1) ), ascorbic acid (vitamin C), and cortisol concentrations in healthy and ill neonatal foals. J Vet Intern Med 2021 Jul;35(4):1988-1994.
    doi: 10.1111/jvim.16188pubmed: 34056771google scholar: lookup
  9. Furr M, McKenzie H 3rd. Factors associated with the risk of positive blood culture in neonatal foals presented to a referral center (2000-2014). J Vet Intern Med 2020 Nov;34(6):2738-2750.
    doi: 10.1111/jvim.15923pubmed: 33044020google scholar: lookup
  10. Anderson MJ, Ibrahim AS, Cooper BR, Woolcock AD, Moore GE, Taylor SD. Effects of administration of ascorbic acid and low-dose hydrocortisone after infusion of sublethal doses of lipopolysaccharide to horses. J Vet Intern Med 2020 Nov;34(6):2710-2718.
    doi: 10.1111/jvim.15896pubmed: 33026127google scholar: lookup
  11. Flash ML, Wong ASM, Stevenson MA, Gilkerson JR. Barriers to entering race training before 4 years of age for Thoroughbred horses born in the 2014 Australian foal crop. PLoS One 2020;15(8):e0237003.
    doi: 10.1371/journal.pone.0237003pubmed: 32756576google scholar: lookup
  12. Monteiro LC, Viana RB, Avanza MFB, Ermita PAN, Costa CM, Alves SR, Santos PVM, da Silva MO, Balbino DAB, de Mattos FS, Teixeira RBC, Ribeiro Filho JD. Effects of Hypotonic and Isotonic Enteral Electrolyte Solutions Administered in Continuous Flow in Weaned Foals. Front Vet Sci 2020;7:280.
    doi: 10.3389/fvets.2020.00280pubmed: 32596264google scholar: lookup
  13. Husso A, Jalanka J, Alipour MJ, Huhti P, Kareskoski M, Pessa-Morikawa T, Iivanainen A, Niku M. The composition of the perinatal intestinal microbiota in horse. Sci Rep 2020 Jan 16;10(1):441.
    doi: 10.1038/s41598-019-57003-8pubmed: 31949191google scholar: lookup
  14. Sheats MK. A Comparative Review of Equine SIRS, Sepsis, and Neutrophils. Front Vet Sci 2019;6:69.
    doi: 10.3389/fvets.2019.00069pubmed: 30931316google scholar: lookup
  15. Wong DM, Ruby RE, Dembek KA, Barr BS, Reuss SM, Magdesian KG, Olsen E, Burns T, Slovis NM, Wilkins PA. Evaluation of updated sepsis scoring systems and systemic inflammatory response syndrome criteria and their association with sepsis in equine neonates. J Vet Intern Med 2018 May;32(3):1185-1193.
    doi: 10.1111/jvim.15087pubmed: 29582480google scholar: lookup
  16. Oliver-Espinosa O. Foal Diarrhea: Established and Postulated Causes, Prevention, Diagnostics, and Treatments. Vet Clin North Am Equine Pract 2018 Apr;34(1):55-68.
    doi: 10.1016/j.cveq.2017.11.003pubmed: 29395727google scholar: lookup
  17. Rutenberg D, Venner M, Giguère S. Efficacy of Tulathromycin for the Treatment of Foals with Mild to Moderate Bronchopneumonia. J Vet Intern Med 2017 May;31(3):901-906.
    doi: 10.1111/jvim.14717pubmed: 28421633google scholar: lookup
  18. Tapprest J, Morignat E, Dornier X, Borey M, Hendrikx P, Ferry B, Calavas D, Sala C. Fallen stock data: An essential source of information for quantitative knowledge of equine mortality in France. Equine Vet J 2017 Sep;49(5):596-602.
    doi: 10.1111/evj.12664pubmed: 28079926google scholar: lookup
  19. Yamada K, Sato F, Horiuchi N, Higuchi T, Kobayashi Y, Sasaki N, Nambo Y. Autopsy imaging for cardiac tamponade in a Thoroughbred foal. J Equine Sci 2016;27(3):115-118.
    doi: 10.1294/jes.27.115pubmed: 27703406google scholar: lookup
  20. Giguère S, Berghaus LJ, Miller CD. Clinical Assessment of a Point-of-Care Serum Amyloid A Assay in Foals with Bronchopneumonia. J Vet Intern Med 2016 Jul;30(4):1338-43.
    doi: 10.1111/jvim.13978pubmed: 27296082google scholar: lookup
  21. Rogers CW, Bolwell CF, Gee EK. Proactive Management of the Equine Athlete. Animals (Basel) 2012 Dec 19;2(4):640-55.
    doi: 10.3390/ani2040640pubmed: 26487168google scholar: lookup
  22. Zabrecky KA, Slovis NM, Constable PD, Taylor SD. Plasma C-reactive protein and haptoglobin concentrations in critically ill neonatal foals. J Vet Intern Med 2015 Mar-Apr;29(2):673-7.
    doi: 10.1111/jvim.12568pubmed: 25818221google scholar: lookup
  23. Hildebrand F, Venner M, Giguère S. Efficacy of gamithromycin for the treatment of foals with mild to moderate bronchopneumonia. J Vet Intern Med 2015 Jan;29(1):333-8.
    doi: 10.1111/jvim.12504pubmed: 25619521google scholar: lookup
  24. Cohen ND, Bourquin JR, Bordin AI, Kuskie KR, Brake CN, Weaver KB, Liu M, Felippe MJ, Kogut MH. Intramuscular administration of a synthetic CpG-oligodeoxynucleotide modulates functional responses of neutrophils of neonatal foals. PLoS One 2014;9(10):e109865.
    doi: 10.1371/journal.pone.0109865pubmed: 25333660google scholar: lookup
  25. Toth B, Slovis NM, Constable PD, Taylor SD. Plasma adrenomedullin concentrations in critically ill neonatal foals. J Vet Intern Med 2014 Jul-Aug;28(4):1294-300.
    doi: 10.1111/jvim.12358pubmed: 24773029google scholar: lookup
  26. Galvin N, Corley K. Causes of disease and death from birth to 12 months of age in the Thoroughbred horse in Ireland. Ir Vet J 2010 Jan 1;63(1):37-43.
    doi: 10.1186/2046-0481-63-1-37pubmed: 21851741google scholar: lookup
  27. Staempfli SA, Saied A, Wakamatsu N, Serra V, Eades SC. Therapy resistant septic enteritis due to a jejunal malformation in a 5-day-old Thoroughbred colt. Can Vet J 2011 Feb;52(2):142-6.
    pubmed: 21532818
  28. Hart KA, Barton MH, Vandenplas ML, Hurley DJ. Effects of low-dose hydrocortisone therapy on immune function in neonatal horses. Pediatr Res 2011 Jul;70(1):72-7.
    doi: 10.1203/PDR.0b013e31821b502bpubmed: 21430601google scholar: lookup
  29. Grinberg A, Learmonth J, Kwan E, Pomroy W, Lopez Villalobos N, Gibson I, Widmer G. Genetic diversity and zoonotic potential of Cryptosporidium parvum causing foal diarrhea. J Clin Microbiol 2008 Jul;46(7):2396-8.
    doi: 10.1128/JCM.00936-08pubmed: 18508944google scholar: lookup
  30. Magdesian KG. Neonatal foal diarrhea. Vet Clin North Am Equine Pract 2005 Aug;21(2):295-312, vi.
    doi: 10.1016/j.cveq.2005.04.009pubmed: 16051051google scholar: lookup
  31. Leblond A, Villard I, Leblond L, Sabatier P, Sasco AJ. A retrospective evaluation of the causes of death of 448 insured French horses in 1995. Vet Res Commun 2000 Mar;24(2):85-102.
    doi: 10.1023/a:1006408522233pubmed: 10720095google scholar: lookup
  32. Chen LT, Wesdorp E, Jager M, Siegers EW, Theelen MJP, Besselink N, Vermeulen C, Zomer AL, Broens EM, Wagenaar JA, de Ridder J. Bacterial cell-free DNA profiling reveals the co-elevation of multiple bacteria in newborn foals with suspected sepsis. iScience 2025 Dec 19;28(12):114005.
    doi: 10.1016/j.isci.2025.114005pubmed: 41476946google scholar: lookup
  33. Mouncey R, de Mestre AM, Verheyen KL. Born to run? Racing and training outcomes, population dynamics and traceability of a Thoroughbred birth cohort. Vet Rec 2025 Oct 4;197(7):e5777.
    doi: 10.1002/vetr.5777pubmed: 41000051google scholar: lookup
  34. Sahoo DK, Wong D, Paital B, Ruby RE, Patel A. Role of Endoplasmic Reticulum Stress-Associated Genes in Septic Neonatal Foals. Antioxidants (Basel) 2025 Aug 21;14(8).
    doi: 10.3390/antiox14081024pubmed: 40867920google scholar: lookup
  35. Zhu D, Li S, Xu Z, Kulyar MF, Bai X, Wang Y, Wang B, Khateeb E, Deng D, Wang L, Chen Y, Guo A, Shen Y. Comparative analysis of gut microbiota in healthy and diarrheic foals. Microbiol Spectr 2025 Mar 19;13(5):e0087124.
    doi: 10.1128/spectrum.00871-24pubmed: 40105330google scholar: lookup
  36. Wong D, Sahoo DK, Faivre C, Kopper J, Dersh K, Beachler T, Esser M. Oxidative stress in critically ill neonatal foals. J Vet Intern Med 2025 Jan-Feb;39(1):e17297.
    doi: 10.1111/jvim.17297pubmed: 39854109google scholar: lookup
  37. Raidal SL, van Diggelen M, Catanchin CSM, Lehmann HS, Quinn CT. Use of prototype bi-nasal prongs for noninvasive ventilation in foals. J Vet Intern Med 2024 Nov-Dec;38(6):3327-3336.
    doi: 10.1111/jvim.17170pubmed: 39375942google scholar: lookup
  38. Taylor SD, Hart KA, Vaughn S, Giancola SC, Serpa PBS, Santos AP. Effects of intravenous administration of ascorbic acid (vitamin C) on oxidative status in healthy adult horses. J Vet Intern Med 2024 Jan-Feb;38(1):460-468.
    doi: 10.1111/jvim.16934pubmed: 37948618google scholar: lookup
  39. Hostetter SJ, Clark SK, Gilbertie JM, Wiechert SA, Jones DE, Sponseller BA. Age-related variation in the cellular composition of equine bronchoalveolar lavage fluid. Vet Clin Pathol 2017 Jun;46(2):344-353.
    doi: 10.1111/vcp.12473pubmed: 28346682google scholar: lookup
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