Current Trends in Understanding and Managing Equine Rhodococcosis.
- Journal Article
- Review
Summary
This research article presents a summary of the major breakthroughs and trends in understanding and managing equine rhodococcosis, an infectious disease that affects horses, over the last ten years. The study encompasses a range of topics including animal susceptibility, diagnostic procedures, treatment alternatives, and preventative measures.
Understanding Neonatal Susceptibility
The researchers have compiled evidence that sheds light on the susceptibility of equine neonates to rhodococcosis. This involves:
- Identifying the genetic and environmental factors that make them more susceptible to the disease
- Exploring how their immune system responds to infection
Clinical Appearance
The researchers discuss the complexity of the clinical appearance of rhodococcosis. This includes:
- Analyzing its symptoms and how they differ from one horse to another
- Examining the different stages of the disease and how they present clinically
Diagnostic Procedures and Treatment Alternatives
The paper explores the latest diagnostic procedures being considered and applied for rhodococcosis detection. In terms of treatment, a range of alternatives and advancements are outlined:
- Presenting novel ways of detecting the bacterium that causes rhodococcosis
- Describing recent advancements in antibiotic therapy and other treatment measures
Prognosis Limitations and Prophylaxis Considerations
The article discusses the difficulties in making accurate predictions about the course and outcome of rhodococcosis in horses. Additionally, the authors delve into potential measures for preventing the disease:
- Addressing the challenges faced when predicting the progression of the disease
- Providing updated recommendations and strategies for prevention of rhodococcosis
Unresolved Problems and Future Efforts
Despite considerable progress in understanding and managing equine rhodococcosis, the study highlights persisting issues with high morbidity and mortality, unreliable prevention strategies, and limitations in treatment. As such, researchers argue for:
- Further research and scientific effort to address these ongoing challenges
- Emphasizing the need for more effective treatment and prevention strategies for this serious equine disease
Cite This Article
Publication
Researcher Affiliations
- Department of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-787 Warszawa, Poland.
- Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 1, 02-787 Warszawa, Poland.
- Department of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-787 Warszawa, Poland.
Conflict of Interest Statement
References
- Giguère S, Roberts GD. Association between radiographic pattern and outcome in foals with pneumonia caused by Rhodococcus equi.. Vet Radiol Ultrasound 2012 Nov-Dec;53(6):601-4.
- Huber L, Gressler L.T, Sanz M.G, Garbade P, Vargas Á, Silveira B.P. Monitoring Foals by Thoracic Ultrasonography, Bacterial Culture, and PCR: Diagnostic of Rhodococcus Equi Subclinical Pneumonia in South of Brazil. J. Equine Vet. Sci. 2018;60:104–108.e1.
- Treloar S.K, Dhand N.K, Muscatello G. Rhodococcus Equi Pneumonia and Future Racing Performance of the Thoroughbred. J. Equine Vet. Sci. 2012;32:S16–S17.
- Giguère S, Cohen ND, Chaffin MK, Slovis NM, Hondalus MK, Hines SA, Prescott JF. Diagnosis, treatment, control, and prevention of infections caused by Rhodococcus equi in foals.. J Vet Intern Med 2011 Nov-Dec;25(6):1209-20.
- Coulson GB, Miranda-CasoLuengo AA, Miranda-CasoLuengo R, Wang X, Oliver J, Willingham-Lane JM, Meijer WG, Hondalus MK. Transcriptome reprogramming by plasmid-encoded transcriptional regulators is required for host niche adaption of a macrophage pathogen.. Infect Immun 2015 Aug;83(8):3137-45.
- Cohen ND, Carter CN, Scott HM, Chaffin MK, Smith JL, Grimm MB, Kuskie KR, Takai S, Martens RJ. Association of soil concentrations of Rhodococcus equi and incidence of pneumonia attributable to Rhodococcus equi in foals on farms in central Kentucky.. Am J Vet Res 2008 Mar;69(3):385-95.
- Witkowski L. Treatment and prevention of Rhodococcus equi in foals.. Vet Rec 2019 Jul 6;185(1):16-18.
- Hondalus MK, Mosser DM. Survival and replication of Rhodococcus equi in macrophages.. Infect Immun 1994 Oct;62(10):4167-75.
- Rofe AP, Davis LJ, Whittingham JL, Latimer-Bowman EC, Wilkinson AJ, Pryor PR. The Rhodococcus equi virulence protein VapA disrupts endolysosome function and stimulates lysosome biogenesis.. Microbiologyopen 2017 Apr;6(2).
- Chaffin MK, Cohen ND, Martens RJ. Evaluation of equine breeding farm management and preventative health practices as risk factors for development of Rhodococcus equi pneumonia in foals.. J Am Vet Med Assoc 2003 Feb 15;222(4):476-85.
- Vázquez-Boland JA, Giguère S, Hapeshi A, MacArthur I, Anastasi E, Valero-Rello A. Rhodococcus equi: the many facets of a pathogenic actinomycete.. Vet Microbiol 2013 Nov 29;167(1-2):9-33.
- Cohen ND, Chaffin MK, Kuskie KR, Syndergaard MK, Blodgett GP, Takai S. Association of perinatal exposure to airborne Rhodococcus equi with risk of pneumonia caused by R equi in foals.. Am J Vet Res 2013 Jan;74(1):102-9.
- Sanz M, Loynachan A, Sun L, Oliveira A, Breheny P, Horohov DW. The effect of bacterial dose and foal age at challenge on Rhodococcus equi infection.. Vet Microbiol 2013 Dec 27;167(3-4):623-31.
- Leclere M, Magdesian KG, Kass PH, Pusterla N, Rhodes DM. Comparison of the clinical, microbiological, radiological and haematological features of foals with pneumonia caused by Rhodococcus equi and other bacteria.. Vet J 2011 Jan;187(1):109-12.
- Giguère S, Jordan LM, Glass K, Cohen ND. Relationship of mixed bacterial infection to prognosis in foals with pneumonia caused by Rhodococcus equi.. J Vet Intern Med 2012 Nov-Dec;26(6):1443-8.
- McQueen CM, Dindot SV, Foster MJ, Cohen ND. Genetic Susceptibility to Rhodococcus equi.. J Vet Intern Med 2015 Nov-Dec;29(6):1648-59.
- Whitfield-Cargile CM, Cohen ND, Suchodolski J, Chaffin MK, McQueen CM, Arnold CE, Dowd SE, Blodgett GP. Composition and Diversity of the Fecal Microbiome and Inferred Fecal Metagenome Does Not Predict Subsequent Pneumonia Caused by Rhodococcus equi in Foals.. PLoS One 2015;10(8):e0136586.
- Reuss SM, Chaffin MK, Cohen ND. Extrapulmonary disorders associated with Rhodococcus equi infection in foals: 150 cases (1987-2007).. J Am Vet Med Assoc 2009 Oct 1;235(7):855-63.
- Tarancón I, Leiva M, Jose-Cunilleras E, Ríos J, Peña T. Ophthalmologic findings associated with Rhodococcus equi bronchopneumonia in foals.. Vet Ophthalmol 2019 Sep;22(5):660-665.
- Reuss SM, Chaffin MK, Schmitz DG, Norman TE. Sonographic characteristics of intraabdominal abscessation and lymphadenopathy attributable to Rhodococcus equi infections in foals.. Vet Radiol Ultrasound 2011 Jul-Aug;52(4):462-5.
- Reuss S.M. Extrapulmonary Disorders Associated with Rhodococcus equi Infections. Equine Vet. Educ. 2016;28:193–195.
- Morresey P.R, Garrett K.S, Carter D. Rhodococcus equi Occipital Bone Osteomyelitis, Septic Arthritis and Meningitis in a Neurological Foal. Equine Vet. Educ. 2011;23:398–402.
- Hines M.T. Rhodococcus equi in Equine Infectious Diseases. 2nd ed. Sellon D.C., Long M.T., editors. Elsevier; St. Louis, MO, USA: 2014. p. 294.
- Giguère S, Prescott JF. Clinical manifestations, diagnosis, treatment, and prevention of Rhodococcus equi infections in foals.. Vet Microbiol 1997 Jun 16;56(3-4):313-34.
- Bedenice D, Heuwieser W, Brawer R, Solano M, Rand W, Paradis MR. Clinical and prognostic significance of radiographic pattern, distribution, and severity of thoracic radiographic changes in neonatal foals.. J Vet Intern Med 2003 Nov-Dec;17(6):876-86.
- Bedenice D, Heuwieser W, Solano M, Rand W, Paradis MR. Risk factors and prognostic variables for survival of foals with radiographic evidence of pulmonary disease.. J Vet Intern Med 2003 Nov-Dec;17(6):868-75.
- Giguère S, Hernandez J, Gaskin J, Miller C, Bowman JL. Evaluation of white blood cell concentration, plasma fibrinogen concentration, and an agar gel immunodiffusion test for early identification of foals with Rhodococcus equi pneumonia.. J Am Vet Med Assoc 2003 Mar 15;222(6):775-81.
- Giguère S, Cohen N.D. Controversies in Therapy of Infections Caused by Rhodococcus equi in Foals. Equine Vet. Educ. 2018;30:336–341.
- Arnold-Lehna D, Venner M, Berghaus LJ, Berghaus R, Giguère S. Changing policy to treat foals with Rhodococcus equi pneumonia in the later course of disease decreases antimicrobial usage without increasing mortality rate.. Equine Vet J 2020 Jul;52(4):531-537.
- Wetzig M, Venner M, Giguère S. Efficacy of the combination of doxycycline and azithromycin for the treatment of foals with mild to moderate bronchopneumonia.. Equine Vet J 2020 Jul;52(4):613-619.
- Rantanen N.W. Evaluation of the Respiratory System. Equine Diagnostic Ultrasonography Williams Wilkins; Baltimore, MD, USA: 1998.
- Ramirez S, Lester GD, Roberts GR. Diagnostic contribution of thoracic ultrasonography in 17 foals with Rhodococcus equi pneumonia.. Vet Radiol Ultrasound 2004 Mar-Apr;45(2):172-6.
- Hillidge CJ. Use of erythromycin-rifampin combination in treatment of Rhodococcus equi pneumonia.. Vet Microbiol 1987 Aug;14(3):337-42.
- Passamonti F, Vardi DM, Stefanetti V, Marenzoni ML, Prato S, Cévese P, Coletti M, Pepe M, Casagrande Proietti P, Olea-Popelka F. Rhodococcus equi pneumonia in foals: an assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice.. Vet J 2015 Feb;203(2):211-8.
- Giguère S, Berghaus LJ, Miller CD. Clinical Assessment of a Point-of-Care Serum Amyloid A Assay in Foals with Bronchopneumonia.. J Vet Intern Med 2016 Jul;30(4):1338-43.
- Cohen ND, Chaffin MK, Vandenplas ML, Edwards RF, Nevill M, Moore JN, Martens RJ. Study of serum amyloid A concentrations as a means of achieving early diagnosis of Rhodococcus equi pneumonia.. Equine Vet J 2005 May;37(3):212-6.
- Madrigal RG, Shaw SD, Witkowski LA, Sisson BE, Blodgett GP, Chaffin MK, Cohen ND. Use of Serial Quantitative PCR of the vapA Gene of Rhodococcus equi in Feces for Early Detection of R. equi Pneumonia in Foals.. J Vet Intern Med 2016 Mar-Apr;30(2):664-70.
- Giguère S, Hernandez J, Gaskin J, Prescott JF, Takai S, Miller C. Performance of five serological assays for diagnosis of Rhodococcus equi pneumonia in foals.. Clin Diagn Lab Immunol 2003 Mar;10(2):241-5.
- Giguère S, Berghaus L.J, Willingham-Lane J.M. Antimicrobial Resistance in Rhodococcus Equi. Microbiol. Spectr. 2017.
- Mercer MA, Davis JL. Clinical insights: Antimicrobials in an age of resistance.. Equine Vet J 2019 Nov;51(6):711-713.
- Witkowski L, Rzewuska M, Takai S, Chrobak-Chmiel D, Kizerwetter-Świda M, Feret M, Gawryś M, Witkowski M, Kita J. Molecular characterization of Rhodococcus equi isolates from horses in Poland: pVapA characteristics and plasmid new variant, 85-kb type V.. BMC Vet Res 2017 Jan 26;13(1):35.
- Huber L, Giguère S, Cohen ND, Slovis NM, Hanafi A, Schuckert A, Berghaus L, Greiter M, Hart KA. Prevalence and risk factors associated with emergence of Rhodococcus equi resistance to macrolides and rifampicin in horse-breeding farms in Kentucky, USA.. Vet Microbiol 2019 Aug;235:243-247.
- . Critically Important Antimicrobials for Human Medicine-6th Revision 2018 Ranking of Medically Important Antimicrobials for Risk Management of Antimicrobial Resistance Due to Non-Human Use. [(accessed on 18 October 2020)]; Available online: https://apps.who.int/iris/bitstream/handle/10665/312266/9789241515528-eng.pdf?ua=1.
- Venner M, Astheimer K, Lämmer M, Giguère S. Efficacy of mass antimicrobial treatment of foals with subclinical pulmonary abscesses associated with Rhodococcus equi.. J Vet Intern Med 2013 Jan-Feb;27(1):171-6.
- Rutenberg D, Venner M, Giguère S. Efficacy of Tulathromycin for the Treatment of Foals with Mild to Moderate Bronchopneumonia.. J Vet Intern Med 2017 May;31(3):901-906.
- Hildebrand F, Venner M, Giguère S. Efficacy of gamithromycin for the treatment of foals with mild to moderate bronchopneumonia.. J Vet Intern Med 2015 Jan;29(1):333-8.
- Cauchard S, Giguère S, Venner M, Muscatello G, Cauchard J, Cohen ND, Haas A, Hines SA, Hondalus MK, Horohov DW, Meijer WG, Prescott JF, Vázquez-Boland J. Rhodococcus equi research 2008-2012: report of the Fifth International Havemeyer Workshop.. Equine Vet J 2013 Sep;45(5):523-6.
- Berghaus LJ, Giguère S, Guldbech K. Mutant prevention concentration and mutant selection window for 10 antimicrobial agents against Rhodococcus equi.. Vet Microbiol 2013 Oct 25;166(3-4):670-5.
- Cohen ND, Giguère S, Burton AJ, Rocha JN, Berghaus LJ, Brake CN, Bordin AI, Coleman MC. Use of Liposomal Gentamicin for Treatment of 5 Foals with Experimentally Induced Rhodococcus equi Pneumonia.. J Vet Intern Med 2016 Jan-Feb;30(1):322-5.
- Cohen ND, Slovis NM, Giguère S, Baker S, Chaffin MK, Bernstein LR. Gallium maltolate as an alternative to macrolides for treatment of presumed Rhodococcus equi pneumonia in foals.. J Vet Intern Med 2015 May-Jun;29(3):932-9.
- McCracken J.L, Slovis N.M, Acvim D. Use of Thoracic Ultrasound for the Prevention of Rhodococcus equi Pneumonia on Endemic Farms. Proc. Am. Assoc. Equine Pract. 2009;55:38–44.
- Chaffin MK, Cohen ND, Martens RJ. Chemoprophylactic effects of azithromycin against Rhodococcus equi-induced pneumonia among foals at equine breeding farms with endemic infections.. J Am Vet Med Assoc 2008 Apr 1;232(7):1035-47.
- Huber L, Giguère S, Slovis NM, Carter CN, Barr BS, Cohen ND, Elam J, Erol E, Locke SJ, Phillips ED, Smith JL. Emergence of Resistance to Macrolides and Rifampin in Clinical Isolates of Rhodococcus equi from Foals in Central Kentucky, 1995 to 2017.. Antimicrob Agents Chemother 2019 Jan;63(1).
- Burton AJ, Giguère S, Sturgill TL, Berghaus LJ, Slovis NM, Whitman JL, Levering C, Kuskie KR, Cohen ND. Macrolide- and rifampin-resistant Rhodococcus equi on a horse breeding farm, Kentucky, USA.. Emerg Infect Dis 2013 Feb;19(2):282-5.
- Giguère S, Jacks S, Roberts GD, Hernandez J, Long MT, Ellis C. Retrospective comparison of azithromycin, clarithromycin, and erythromycin for the treatment of foals with Rhodococcus equi pneumonia.. J Vet Intern Med 2004 Jul-Aug;18(4):568-73.
- Venner M, Reinhold B, Beyerbach M, Feige K. Efficacy of azithromycin in preventing pulmonary abscesses in foals.. Vet J 2009 Feb;179(2):301-3.
- Kahn SK, Blodgett GP, Canaday NM, Bevevino KE, Rocha JN, Bordin AI, Cohen ND. Transfusion With 2 L of Hyperimmune Plasma is Superior to Transfusion of 1 L or Less for Protecting Foals Against Subclinical Pneumonia Attributed to Rhodococcus equi.. J Equine Vet Sci 2019 Aug;79:54-58.
- Swerczek T.W. Pathogenesis, Treatment, and Control of Streptococcus Equi Infection (Strangles) in Horses. Proceedings of the First Annual Eastern States Veterinary Conference; Orland, FL, USA. 18 January 1984.
- Walter Swerczek T. Exacerbation of Streptococcus Equi (Strangles) by Overly Nutritious Diets in Horses: A Model for Infectious Bacterial Diseases of Horses and Other Livestock. Anim. Vet. Sci. 2019;7:18.
- Huber L, Giguère S, Berghaus LJ, Hanafi A, Ryan C. Fecal shedding of Rhodococcus equi in mares and foals after experimental infection of foals and effect of composting on concentrations of R. equi in contaminated bedding.. Vet Microbiol 2018 Sep;223:42-46.
- Ward AL, Reddyvari P, Borisova R, Shilabin AG, Lampson BC. An inhibitory compound produced by a soil isolate of Rhodococcus has strong activity against the veterinary pathogen R. equi.. PLoS One 2018;13(12):e0209275.
- Rocha JN, Cohen ND, Bordin AI, Brake CN, Giguère S, Coleman MC, Alaniz RC, Lawhon SD, Mwangi W, Pillai SD. Oral Administration of Electron-Beam Inactivated Rhodococcus equi Failed to Protect Foals against Intrabronchial Infection with Live, Virulent R. equi.. PLoS One 2016;11(2):e0148111.
- Perkins GA, Wagner B. The development of equine immunity: Current knowledge on immunology in the young horse.. Equine Vet J 2015 May;47(3):267-74.
- Sanz MG, Loynachan A, Horohov DW. Rhodococcus equi hyperimmune plasma decreases pneumonia severity after a randomised experimental challenge of neonatal foals.. Vet Rec 2016 Mar 12;178(11):261.
- Erganis O, Sayin Z, Hadimli HH, Sakmanoglu A, Pinarkara Y, Ozdemir O, Maden M. The effectiveness of anti-R. equi hyperimmune plasma against R. equi challenge in thoroughbred Arabian foals of mares vaccinated with R. equi vaccine.. ScientificWorldJournal 2014;2014:480732.
- Witkowski L, Kaba J, Rzewuska M, Nowicki M, Szaluś-Jordanow O, Kita J. Development of ELISA test for determination of the level of antibodies against Rhodococcus equi in equine serum and colostrum.. Vet Immunol Immunopathol 2012 Oct 15;149(3-4):280-5.
- Bordin AI, Pillai SD, Brake C, Bagley KB, Bourquin JR, Coleman M, Oliveira FN, Mwangi W, McMurray DN, Love CC, Felippe MJ, Cohen ND. Immunogenicity of an electron beam inactivated Rhodococcus equi vaccine in neonatal foals.. PLoS One 2014;9(8):e105367.
- Cywes-Bentley C, Rocha JN, Bordin AI, Vinacur M, Rehman S, Zaidi TS, Meyer M, Anthony S, Lambert M, Vlock DR, Giguère S, Cohen ND, Pier GB. Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi.. PLoS Pathog 2018 Jul;14(7):e1007160.
Citations
This article has been cited 5 times.- Knox A, Zerna G, Beddoe T. Current and Future Advances in the Detection and Surveillance of Biosecurity-Relevant Equine Bacterial Diseases Using Loop-Mediated Isothermal Amplification (LAMP).. Animals (Basel) 2023 Aug 18;13(16).
- Sting R, Schwabe I, Kieferle M, Münch M, Rau J. Fatal Infection in an Alpaca (Vicugna pacos) Caused by Pathogenic Rhodococcus equi.. Animals (Basel) 2022 May 19;12(10).
- Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Padalino B, Pasquali P, Roberts HC, Spoolder H, Ståhl K, Velarde A, Viltrop A, Winckler C, Baldinelli F, Broglia A, Kohnle L, Alvarez J. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Rhodococcus equi in horses.. EFSA J 2022 Feb;20(2):e07081.
- Kahn SK, Cywes-Bentley C, Blodgett GP, Canaday NM, Turner-Garcia CE, Flores-Ahlschwede P, Metcalfe LL, Nevill M, Vinacur M, Sutter PJ, Meyer SC, Bordin AI, Pier GB, Cohen ND. Randomized, controlled trial comparing Rhodococcus equi and poly-N-acetyl glucosamine hyperimmune plasma to prevent R equi pneumonia in foals.. J Vet Intern Med 2021 Nov;35(6):2912-2919.
- Żychska M, Witkowski L, Klementowska A, Rzewuska M, Kwiecień E, Stefańska I, Czopowicz M, Szaluś-Jordanow O, Mickiewicz M, Moroz A, Bonecka J, Kaba J. Rhodococcus equi-Occurrence in Goats and Clinical Case Report.. Pathogens 2021 Sep 4;10(9).