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Vaccine2006; 25(30); 5606-5612; doi: 10.1016/j.vaccine.2006.11.066

Development and registration of recombinant veterinary vaccines. The example of the canarypox vector platform.

Abstract: The canarypox vaccine vector (ALVAC) technology has been used to develop and license several vaccines for companion animals and horses in the European Union and USA. ALVAC is a ubiquitous vector with high biosafety since it is non-replicative in mammalians, is genetically and physically stable, and able to induce both humoral and cell-mediated immune responses against the expressed transgene product. Specific rules apply for the development and registration of recombinant vector vaccines. The biology of the vector as well as the recombinant virus must be thoroughly documented to allow the risk assessment of its use in the target species. In particular, its safety for the host and the environment must be extensively demonstrated before field trials can be authorized.
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Publication Date: 2006-12-08 PubMed ID: 17227690DOI: 10.1016/j.vaccine.2006.11.066Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the use of canarypox vaccine vector (ALVAC) to develop and procure multiple vaccines for domestic and equine animals in Europe and the U.S. The article emphasizes the importance of understanding both the biology of the vector and the recombinant virus to ensure its safety, as well as the need for extensive trials before it is approved for use.

Canarypox Vaccine Vector (ALVAC)

  • The research paper discusses the characteristics of the ALVAC, a canarypox vaccine vector utilized for developing different vaccines. It notes its ubiquity, high safety margin, and the structural and genetic stability of this technology.
  • ALVAC is noted as non-replicative in mammals, which contributes to its safety profile. Its ability to elicit both humoral (antibody-mediated) and cell-mediated immune responses is also highlighted, signifying its effectiveness in inducing immunity against diseases.

Development and Registration of Vaccines

  • The study underscores the inherent regulations in the development and registration of recombinant vector vaccines, emphasizing the sector’s stringent procedures.
  • The research underscores the importance of comprehensive knowledge about the vector biology as well as the recombinant virus. Understanding these entities aids in assessing the potential risks associated with its use in the identified species.

Risk Assessment and Trials

  • The paper emphasizes the need for comprehensive risk assessment before the recombinant vector vaccines’ use. Fundamentally, the safety of the host and the environmental impact must be extensively evaluated.
  • The research stresses the importance of extensive demonstration of its safety. For a recombinant vector vaccine to be authorized for field trials, its safety must undergo rigorous assessment and verification processes.

Cite This Article

APA
Poulet H, Minke J, Pardo MC, Juillard V, Nordgren B, Audonnet JC. (2006). Development and registration of recombinant veterinary vaccines. The example of the canarypox vector platform. Vaccine, 25(30), 5606-5612. https://doi.org/10.1016/j.vaccine.2006.11.066

Publication

Vaccine
ISSN: 0264-410X
NlmUniqueID: 8406899
Country: Netherlands
Language: English
Volume: 25
Issue: 30
Pages: 5606-5612

Researcher Affiliations

Poulet, Hervé
  • Merial SAS, 254, rue Marcel Mérieux, 69007 Lyon, France. herve.poulet@merial.com
Minke, Jules
    Pardo, Maria Camila
      Juillard, Véronique
        Nordgren, Bob
          Audonnet, Jean-Christophe

            MeSH Terms

            • Animals
            • Canarypox virus / genetics
            • Drug Approval
            • Genetic Vectors / genetics
            • Vaccines, Synthetic / adverse effects
            • Vaccines, Synthetic / genetics
            • Vaccines, Synthetic / therapeutic use
            • Viral Vaccines / adverse effects
            • Viral Vaccines / genetics
            • Viral Vaccines / therapeutic use

            Citations

            This article has been cited 28 times.
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