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Osteoarthritis and cartilage2008; 16(12); 1519-1525; doi: 10.1016/j.joca.2008.04.015

Effects of exercise vs experimental osteoarthritis on imaging outcomes.

Abstract: To identify changes in imaging outcomes in a controlled model of osteoarthritis (OA) vs exercise. Methods: Sixteen 2-year-old horses were randomly assigned to an exercise control (n=8) or an exercise OA (n=8) group. All horses had middle carpal joints arthroscopically explored and an osteochondral fragment was induced in one middle carpal joint of the OA group. All horses were treadmill exercised for the duration of the study (91 days). Clinical, radiographic, nuclear scintigraphic, computed tomographic and magnetic resonance imaging (MRI) examinations were performed and outcomes of these were compared between groups. Imaging results were correlated to clinical, biomarker and gross pathologic results. Results: The OA group had significant increases in clinical outcomes and most imaging parameters. Specifically, the OA group showed significant increases in radiographic lysis and nuclear scintigraphic uptake. There was very little change in subchondral bone density, but a significant change in subchondral bone edema. Radiographic lysis, radial carpal bone edema and nuclear scintigraphy were strongly correlated with clinical changes and radial carpal bone edema was strongly correlated with changes in Type I and Type II collagen found in the synovial fluid. Conclusions: OA induced significant changes in imaging parameters beyond the adaptation seen with exercise. Bone edema detected with MRI was closely correlated with collagen biomarkers detected in the synovial fluid.
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Publication Date: 2008-05-27 PubMed ID: 18504148DOI: 10.1016/j.joca.2008.04.015Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores how exercise, compared to a model of osteoarthritis (OA), impacts the results from various imaging techniques. These imaging outcomes are further compared for differences between the control group of horses that underwent exercise and the group induced with OA. The findings show that osteoarthritis triggered significant alterations in imaging parameters, beyond the effects of exercise.

Research Methodology

  • The study involved sixteen 2-year-old horses which were randomly divided into two groups: a control group that only exercised (n=8) and an OA group (n=8) in which osteoarthritis was artificially induced as part of the experiment.
  • In the OA group, an osteochondral fragment was induced in one middle carpal joint.
  • All the horses were made to exercise on a treadmill for the duration of 91 days.
  • The horses underwent a series of imaging examinations including radiography, nuclear scintigraphy, computed tomography, and magnetic resonance imaging (MRI).
  • The results from these imaging tests were compared between the two groups. In addition, these imaging outcomes were correlated with clinical outcomes, biomarker results, and gross pathology.

Research Findings

  • The OA group showed substantial increases in clinical outcomes and most imaging parameters, as compared to the control group.
  • Specifically, the OA group had significant increases in radiographic lysis (dissolution or destruction of a membrane) and heightened nuclear scintigraphic uptake.
  • Although no significant change was observed in the subchondral bone density, a major change was noted in the subchondral bone edema.
  • The radiographic lysis, bone edema, and nuclear scintigraphy results strongly correlated with the observable clinical changes.
  • Furthermore, the edema of the radial carpal bone showed strong correlation with changes in Type I and Type II collagen found in the synovial fluid – suggesting a link between bone edema and collagen biomarkers.

Conclusions and Implications

  • Osteoarthritis caused significant changes in imaging parameters, which were beyond the adaptations observed with exercise alone.
  • The significant correlation between the MRI-detected bone edema and collagen biomarkers points towards the question of whether these could be used as potential indicators for diagnosing osteoarthritis.

Cite This Article

APA
Kawcak CE, Frisbie DD, Werpy NM, Park RD, McIlwraith CW. (2008). Effects of exercise vs experimental osteoarthritis on imaging outcomes. Osteoarthritis Cartilage, 16(12), 1519-1525. https://doi.org/10.1016/j.joca.2008.04.015

Publication

Osteoarthritis and cartilage
ISSN: 1522-9653
NlmUniqueID: 9305697
Country: England
Language: English
Volume: 16
Issue: 12
Pages: 1519-1525

Researcher Affiliations

Kawcak, C E
  • Department of Clinical Sciences, Equine Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, United States. ckawcak@colostate.edu
Frisbie, D D
    Werpy, N M
      Park, R D
        McIlwraith, C W

          MeSH Terms

          • Animals
          • Carpus, Animal / metabolism
          • Carpus, Animal / pathology
          • Cartilage, Articular / pathology
          • Diagnostic Imaging
          • Disease Progression
          • Horse Diseases / diagnosis
          • Horses
          • Lameness, Animal / diagnosis
          • Osteoarthritis / pathology
          • Osteoarthritis / veterinary
          • Physical Conditioning, Animal / physiology
          • Random Allocation

          Citations

          This article has been cited 26 times.
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